Ultraviolet-B receptor UVR8 (UVR8) is a 440-residue protein from Arabidopsis thaliana. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9FN03.
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The mean pLDDT of this model is 89.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 83% |
| 70 to 90 | Confident: backbone generally right | 2% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
UV-B specific signaling component that acts as a UV-B photoreceptor and plays a key role in establishing UV-protective responses in plants. Upon UV-B irradiation, UVR8 undergoes an immediate switch from homodimer to monomer, accumulates in the nucleus, interacts with the photomorphogenic repressor COP1 and regulates the expression of the transcription factor HY5 by associating with chromatin (through histone H2B binding) in the HY5 promoter region. UVR8 is involved in controlling aspects of leaf growth and morphogenesis in response to UV-B, is required for normal progression of endocycle and has a regulatory role in stomatal differentiation. Is required for plant circadian clock response…
Homodimer in the absence of UV-B, but absorption of UV-B induces monomerization of UVR8 and interaction with COP1. Interacts with RUP1, RUP2 and histone H2B
Nucleus, Cytoplasm, cytosol
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6QTS | X-ray | 1.11 Å | B=406-413 |
| 6QTQ | X-ray | 1.3 Å | B=406-413 |
| 6XZL | X-ray | 1.39 Å | A=12-381 |
| 4NBM | X-ray | 1.61 Å | A/B/C/D=13-381 |
| 4NAA | X-ray | 1.67 Å | A/B/C/D=13-381 |
| 4D9S | X-ray | 1.7 Å | A/B=1-405 |
| 4NC4 | X-ray | 1.75 Å | A/B/C/D=13-381 |
| 6XZN | X-ray | 1.75 Å | A/B=12-381 |
| 4DNU | X-ray | 1.76 Å | A=10-381 |
| 4DNW | X-ray | 1.77 Å | A/B=12-385 |
| 4DNV | X-ray | 2.0 Å | A/B/C/D=12-381 |
| 6DD7 | X-ray | 2.0 Å | A/B/C/D=13-381 |
| 8GQE | X-ray | 2.0 Å | B=12-421 |
| 6XZM | X-ray | 2.1 Å | A/B=12-381 |
| 7VGG | EM | 3.1 Å | B=1-440 |
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