9CAC: RuvBL lobe of the native human TIP60 complex
Cryo-EM structure of the RuvBL lobe of the native human TIP60 complex (composite structure). Determined by electron microscopy at 3.43 Å resolution. Released 18 Jun 2025.
- Method
- Electron microscopy
- Resolution
- 3.43 Å
- Organism
- Homo sapiens
- Chains
- 13
- Atoms
- 40,858
- Mol. weight
- 970.53 kDa
- Ligands
- ADP, ATP, MG
- Released
- 18 Jun 2025
Explore 9CAC in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9CAC contains 308 α-helices and 280 β-strands across 13 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 69 helices, 33 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 774-791 | 18 | |
| α-helix | 795-797 | 3 | |
| α-helix | 798-800 | 3 | |
| β-strand | 801-802 | 2 | 1 |
| α-helix | 803-806 | 4 | |
| β-strand | 808 | 1 | 2 |
| α-helix | 811-905 | 95 | |
| α-helix | 1057-1067 | 11 | |
| α-helix | 1069-1070 | 2 | |
| α-helix | 1082-1084 | 3 | |
| α-helix | 1093-1107 | 15 | |
| β-strand | 1112-1114 | 3 | 3 |
| α-helix | 1116-1117 | 2 | |
| α-helix | 1122-1135 | 14 | |
| α-helix | 1142 | 1 | |
| β-strand | 1143-1147 | 5 | 3 |
| α-helix | 1149-1162 | 14 | |
| β-strand | 1168-1171 | 4 | 3 |
| α-helix | 1175-1183 | 9 | |
| β-strand | 1193-1197 | 5 | 3 |
| α-helix | 1198-1203 | 6 | |
| α-helix | 1205-1209 | 5 | |
| β-strand | 1213-1219 | 7 | 3 |
| α-helix | 1221-1223 | 3 | |
| α-helix | 1229-1237 | 9 | |
| β-strand | 1240-1246 | 7 | 3 |
| α-helix | 1255-1265 | 11 | |
| α-helix | 1283-1285 | 3 | |
| α-helix | 1286-1300 | 15 | |
| α-helix | 1301-1303 | 3 | |
| β-strand | 1304-1305 | 2 | 3 |
| α-helix | 1313-1315 | 3 | |
| α-helix | 1317-1318 | 2 | |
| β-strand | 1319-1326 | 8 | 4 |
| α-helix | 1327-1329 | 3 | |
| α-helix | 1330-1341 | 12 | |
| α-helix | 1343-1351 | 9 | |
| β-strand | 1353 | 1 | 5 |
| α-helix | 1354-1369 | 16 | |
| α-helix | 1371-1373 | 3 | |
| β-strand | 1380-1381 | 2 | 6 |
| β-strand | 1383-1385 | 3 | 7 |
| α-helix | 1386-1387 | 2 | |
| β-strand | 1390-1391 | 2 | 8 |
| α-helix | 1394-1398 | 5 | |
| α-helix | 1404-1406 | 3 | |
| α-helix | 1410-1413 | 4 | |
| α-helix | 1416-1418 | 3 | |
| α-helix | 1424-1432 | 9 | |
| α-helix | 1434-1436 | 3 | |
| α-helix | 1437-1446 | 10 | |
| α-helix | 1460-1463 | 4 | |
| β-strand | 1464 | 1 | 9 |
| β-strand | 1467-1468 | 2 | 10 |
| β-strand | 1477 | 1 | 9 |
| α-helix | 1740-1762 | 23 | |
| α-helix | 1769-1775 | 7 | |
| α-helix | 1825-1829 | 5 | |
| β-strand | 1838-1840 | 3 | 7 |
| α-helix | 1841-1843 | 3 | |
| β-strand | 1845-1846 | 2 | 8 |
| α-helix | 1852-1869 | 18 | |
| α-helix | 1870-1872 | 3 | |
| α-helix | 1873-1880 | 8 | |
| β-strand | 1885-1886 | 2 | 6 |
| α-helix | 1887-1889 | 3 | |
| α-helix | 1891-1895 | 5 | |
| α-helix | 1898-1912 | 15 | |
| β-strand | 1917-1921 | 5 | 4 |
| α-helix | 1924-1936 | 13 | |
| β-strand | 1941-1944 | 4 | 4 |
| α-helix | 1950-1962 | 13 | |
| β-strand | 1968-1972 | 5 | 4 |
| α-helix | 1977-1979 | 3 | |
| β-strand | 1987-1990 | 4 | 4 |
| α-helix | 1997-2010 | 14 | |
| β-strand | 2016-2023 | 8 | 4 |
| α-helix | 2027-2034 | 8 | |
| α-helix | 2037-2045 | 9 | |
| α-helix | 2050-2052 | 3 | |
| β-strand | 2054 | 1 | 5 |
| α-helix | 2057-2064 | 8 | |
| α-helix | 2094-2096 | 3 | |
| α-helix | 2097-2118 | 22 | |
| α-helix | 2148-2157 | 10 | |
| α-helix | 2161-2172 | 12 | |
| α-helix | 2174-2176 | 3 | |
| α-helix | 2185-2216 | 32 | |
| β-strand | 2222-2223 | 2 | 11 |
| α-helix | 2225-2228 | 4 | |
| β-strand | 2232-2236 | 5 | 12 |
| β-strand | 2242-2244 | 3 | 12 |
| α-helix | 2245-2246 | 2 | |
| β-strand | 2247-2248 | 2 | 13 |
| α-helix | 2249-2254 | 6 | |
| β-strand | 2260 | 1 | 2 |
| α-helix | 2266-2268 | 3 | |
| β-strand | 2270-2274 | 5 | 1 |
| α-helix | 2275-2276 | 2 | |
| α-helix | 2281-2282 | 2 | |
| β-strand | 2283 | 1 | 14 |
| α-helix | 2284 | 1 | |
Chain B: 5 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 169-191 | 23 | |
| α-helix | 195-201 | 7 | |
| β-strand | 211-220 | 10 | 15 |
| β-strand | 260-268 | 9 | 15 |
| α-helix | 271-277 | 7 | |
| α-helix | 281-288 | 8 | |
| β-strand | 291 | 1 | 16 |
| β-strand | 298 | 1 | 16 |
| β-strand | 301-302 | 2 | 17 |
| β-strand | 309-310 | 2 | 17 |
| α-helix | 313-330 | 18 | |
Chain C: 6 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 400-402 | 3 | |
| β-strand | 406 | 1 | 14 |
| β-strand | 412-415 | 4 | 1 |
| α-helix | 416 | 1 | |
| α-helix | 428-430 | 3 | |
| α-helix | 436-438 | 3 | |
| β-strand | 439-440 | 2 | 18 |
| β-strand | 441-444 | 4 | 13 |
| β-strand | 451-459 | 9 | 13 |
| β-strand | 465-469 | 5 | 13 |
| α-helix | 475-480 | 6 | |
| α-helix | 512-522 | 11 | |
| β-strand | 528-529 | 2 | 13 |
| β-strand | 530-532 | 3 | 12 |
Chain E: 25 helices, 28 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 13-14 | 2 | |
| β-strand | 15 | 1 | 19 |
| β-strand | 26 | 1 | 20 |
| α-helix | 31 | 1 | |
| β-strand | 32 | 1 | 20 |
| α-helix | 33 | 1 | |
| β-strand | 35-36 | 2 | 21 |
| β-strand | 39-40 | 2 | 21 |
| α-helix | 43-58 | 16 | |
| β-strand | 61 | 1 | 22 |
| β-strand | 65-69 | 5 | 23 |
| α-helix | 76-87 | 12 | |
| β-strand | 93-96 | 4 | 23 |
| α-helix | 98-101 | 4 | |
| α-helix | 108-118 | 11 | |
| β-strand | 120-139 | 20 | 24 |
| β-strand | 157-162 | 6 | 24 |
| β-strand | 167-172 | 6 | 24 |
| α-helix | 174-183 | 10 | |
| β-strand | 189-194 | 6 | 24 |
| β-strand | 199-206 | 8 | 24 |
| α-helix | 207-211 | 5 | |
| β-strand | 215 | 1 | 25 |
| β-strand | 220-221 | 2 | 24 |
| α-helix | 222-224 | 3 | |
| β-strand | 229-239 | 11 | 24 |
| α-helix | 240-248 | 9 | |
| α-helix | 256-262 | 7 | |
| α-helix | 265-266 | 2 | |
| α-helix | 273-289 | 17 | |
| β-strand | 292-296 | 5 | 24 |
| β-strand | 298-301 | 4 | 23 |
| α-helix | 304-306 | 3 | |
| β-strand | 308 | 1 | 26 |
| α-helix | 309-319 | 11 | |
| β-strand | 326-331 | 6 | 23 |
| β-strand | 333 | 1 | 27 |
| β-strand | 336-337 | 2 | 28 |
| α-helix | 338 | 1 | |
| β-strand | 339 | 1 | 26 |
| β-strand | 345-346 | 2 | 28 |
| α-helix | 352-355 | 4 | |
| β-strand | 358-362 | 5 | 23 |
| α-helix | 364-367 | 4 | |
| α-helix | 368-381 | 14 | |
| β-strand | 386 | 1 | 29 |
| α-helix | 388-399 | 12 | |
| α-helix | 403-408 | 6 | |
| α-helix | 410-419 | 10 | |
| β-strand | 425 | 1 | 29 |
| α-helix | 427-436 | 10 | |
| β-strand | 438 | 1 | 30 |
| α-helix | 440-447 | 8 | |
Chain F: 22 helices, 27 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 22 | 1 | 31 |
| β-strand | 33 | 1 | 32 |
| β-strand | 39 | 1 | 32 |
| β-strand | 42-43 | 2 | 33 |
| β-strand | 46-47 | 2 | 33 |
| α-helix | 50-65 | 16 | |
| β-strand | 68 | 1 | 19 |
| β-strand | 72-77 | 6 | 30 |
| α-helix | 83-94 | 12 | |
| β-strand | 100-104 | 5 | 30 |
| α-helix | 105-108 | 4 | |
| α-helix | 115-125 | 11 | |
| β-strand | 127-150 | 24 | 15 |
| β-strand | 158-164 | 7 | 15 |
| β-strand | 169-173 | 5 | 15 |
| β-strand | 174 | 1 | 25 |
| α-helix | 175 | 1 | |
| α-helix | 176-185 | 10 | |
| β-strand | 191-196 | 6 | 15 |
| β-strand | 202-207 | 6 | 15 |
| α-helix | 210 | 1 | |
| β-strand | 211 | 1 | 15 |
| α-helix | 212 | 1 | |
| α-helix | 225-228 | 4 | |
| β-strand | 233-243 | 11 | 15 |
| α-helix | 244-252 | 9 | |
| α-helix | 256-262 | 7 | |
| α-helix | 270-285 | 16 | |
| β-strand | 289-293 | 5 | 15 |
| β-strand | 295-299 | 5 | 30 |
| α-helix | 301-303 | 3 | |
| β-strand | 305 | 1 | 34 |
| α-helix | 306-315 | 10 | |
| β-strand | 323-328 | 6 | 30 |
| β-strand | 332-334 | 3 | 35 |
| α-helix | 335 | 1 | |
| β-strand | 336 | 1 | 34 |
| β-strand | 341-343 | 3 | 35 |
| α-helix | 348-352 | 5 | |
| β-strand | 354-359 | 6 | 30 |
| α-helix | 364-378 | 15 | |
| β-strand | 382 | 1 | 36 |
| α-helix | 384-396 | 13 | |
| α-helix | 399-415 | 17 | |
| β-strand | 421 | 1 | 36 |
| α-helix | 423-432 | 10 | |
| β-strand | 434 | 1 | 37 |
| α-helix | 436-445 | 10 | |
| α-helix | 447-449 | 3 | |
Chain G: 24 helices, 26 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 15 | 1 | 38 |
| α-helix | 16 | 1 | |
| β-strand | 26 | 1 | 39 |
| α-helix | 31 | 1 | |
| β-strand | 32 | 1 | 39 |
| α-helix | 33 | 1 | |
| β-strand | 35-36 | 2 | 40 |
| β-strand | 39-40 | 2 | 40 |
| α-helix | 43-58 | 16 | |
| β-strand | 61 | 1 | 31 |
| β-strand | 65-69 | 5 | 37 |
| α-helix | 76-87 | 12 | |
| β-strand | 93-97 | 5 | 37 |
| α-helix | 98-101 | 4 | |
| α-helix | 108-118 | 11 | |
| β-strand | 120-137 | 18 | 15 |
| β-strand | 140-143 | 4 | 15 |
| β-strand | 153-162 | 10 | 15 |
| β-strand | 167-172 | 6 | 15 |
| α-helix | 176-182 | 7 | |
| β-strand | 189-194 | 6 | 15 |
| β-strand | 200-206 | 7 | 15 |
| α-helix | 207-209 | 3 | |
| β-strand | 214-215 | 2 | 41 |
| β-strand | 220-221 | 2 | 15 |
| α-helix | 222-225 | 4 | |
| β-strand | 229-239 | 11 | 15 |
| α-helix | 240-248 | 9 | |
| α-helix | 257-263 | 7 | |
| α-helix | 273-289 | 17 | |
| β-strand | 292-296 | 5 | 15 |
| β-strand | 298-302 | 5 | 37 |
| α-helix | 304-306 | 3 | |
| α-helix | 309-319 | 11 | |
| β-strand | 326-331 | 6 | 37 |
| β-strand | 336-337 | 2 | 42 |
| α-helix | 338 | 1 | |
| β-strand | 345-346 | 2 | 42 |
| α-helix | 352-355 | 4 | |
| β-strand | 358-362 | 5 | 37 |
| α-helix | 365-367 | 3 | |
| α-helix | 368-382 | 15 | |
| β-strand | 386 | 1 | 43 |
| α-helix | 388-399 | 12 | |
| α-helix | 403-408 | 6 | |
| α-helix | 410-419 | 10 | |
| β-strand | 425 | 1 | 43 |
| α-helix | 427-436 | 10 | |
| β-strand | 438 | 1 | 44 |
| α-helix | 440-448 | 9 | |
Chain H: 22 helices, 28 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 22 | 1 | 45 |
| β-strand | 33 | 1 | 46 |
| α-helix | 38 | 1 | |
| β-strand | 39 | 1 | 46 |
| α-helix | 40 | 1 | |
| β-strand | 43 | 1 | 47 |
| β-strand | 46 | 1 | 47 |
| α-helix | 50-65 | 16 | |
| β-strand | 68 | 1 | 38 |
| β-strand | 72-76 | 5 | 44 |
| α-helix | 83-93 | 11 | |
| β-strand | 100-104 | 5 | 44 |
| α-helix | 105-108 | 4 | |
| α-helix | 115-125 | 11 | |
| β-strand | 127-133 | 7 | 48 |
| β-strand | 136-146 | 11 | 41 |
| β-strand | 159-164 | 6 | 41 |
| β-strand | 169-174 | 6 | 41 |
| α-helix | 176-184 | 9 | |
| β-strand | 191-196 | 6 | 41 |
| β-strand | 202-207 | 6 | 41 |
| β-strand | 217 | 1 | 49 |
| β-strand | 224 | 1 | 41 |
| α-helix | 226-229 | 4 | |
| β-strand | 233-235 | 3 | 41 |
| β-strand | 238-243 | 6 | 48 |
| α-helix | 244-252 | 9 | |
| α-helix | 256-258 | 3 | |
| α-helix | 259-262 | 4 | |
| α-helix | 270-286 | 17 | |
| β-strand | 289-293 | 5 | 48 |
| β-strand | 295-299 | 5 | 44 |
| α-helix | 301-303 | 3 | |
| α-helix | 306-315 | 10 | |
| α-helix | 321-322 | 2 | |
| β-strand | 323-328 | 6 | 44 |
| β-strand | 332-334 | 3 | 50 |
| α-helix | 335 | 1 | |
| β-strand | 341-343 | 3 | 50 |
| α-helix | 348-351 | 4 | |
| β-strand | 354-358 | 5 | 44 |
| α-helix | 364-378 | 15 | |
| β-strand | 382 | 1 | 51 |
| α-helix | 384-396 | 13 | |
| α-helix | 399-415 | 17 | |
| β-strand | 421 | 1 | 51 |
| α-helix | 423-432 | 10 | |
| β-strand | 434 | 1 | 52 |
| α-helix | 436-445 | 10 | |
| β-strand | 451 | 1 | 53 |
Chain I: 24 helices, 28 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 15 | 1 | 54 |
| β-strand | 26 | 1 | 55 |
| α-helix | 31 | 1 | |
| β-strand | 32 | 1 | 55 |
| α-helix | 33 | 1 | |
| β-strand | 35-36 | 2 | 56 |
| β-strand | 39-40 | 2 | 56 |
| α-helix | 43-58 | 16 | |
| β-strand | 61 | 1 | 45 |
| β-strand | 65-69 | 5 | 52 |
| α-helix | 76-87 | 12 | |
| β-strand | 93-97 | 5 | 52 |
| α-helix | 98-101 | 4 | |
| α-helix | 108-118 | 11 | |
| β-strand | 120-140 | 21 | 49 |
| β-strand | 157-163 | 7 | 49 |
| β-strand | 166-172 | 7 | 49 |
| α-helix | 175-182 | 8 | |
| β-strand | 189-194 | 6 | 49 |
| β-strand | 200-206 | 7 | 49 |
| α-helix | 207-209 | 3 | |
| β-strand | 215 | 1 | 57 |
| β-strand | 220-221 | 2 | 49 |
| α-helix | 222-224 | 3 | |
| β-strand | 229-239 | 11 | 49 |
| α-helix | 240-246 | 7 | |
| α-helix | 256-263 | 8 | |
| α-helix | 265-266 | 2 | |
| α-helix | 273-289 | 17 | |
| β-strand | 292-296 | 5 | 49 |
| β-strand | 298-302 | 5 | 52 |
| α-helix | 304-306 | 3 | |
| β-strand | 308 | 1 | 58 |
| α-helix | 309-320 | 12 | |
| β-strand | 326-331 | 6 | 52 |
| β-strand | 333 | 1 | 53 |
| β-strand | 335-337 | 3 | 59 |
| α-helix | 338 | 1 | |
| β-strand | 339 | 1 | 58 |
| β-strand | 345-347 | 3 | 59 |
| α-helix | 352-355 | 4 | |
| β-strand | 358-362 | 5 | 52 |
| α-helix | 365-367 | 3 | |
| α-helix | 368-382 | 15 | |
| β-strand | 386 | 1 | 60 |
| α-helix | 388-400 | 13 | |
| α-helix | 403-408 | 6 | |
| α-helix | 410-419 | 10 | |
| β-strand | 425 | 1 | 60 |
| α-helix | 427-436 | 10 | |
| β-strand | 438 | 1 | 61 |
| α-helix | 440-448 | 9 | |
5 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| E1A-binding protein p400 | A | protein | 3159 | Homo sapiens | Q96L91 |
| Vacuolar protein sorting-associated protein 72 homolog | B | protein | 364 | Homo sapiens | Q15906 (AlphaFold model) |
| Enhancer of polycomb homolog 1 | C | protein | 836 | Homo sapiens | Q9H2F5 (AlphaFold model) |
| RuvB-like 1 | E, G, I | protein | 456 | Homo sapiens | Q9Y265 (AlphaFold model) |
| RuvB-like 2 | F, H, J | protein | 463 | Homo sapiens | Q9Y230 |
| Actin, cytoplasmic 1 | K, L | protein | 375 | Homo sapiens | P60709 |
| Actin-like protein 6A | M | protein | 429 | Homo sapiens | O96019 |
| DNA methyltransferase 1-associated protein 1 | N | protein | 467 | Homo sapiens | Q9NPF5 |
Sequence of entity 1 (A), FASTA
>9CAC_1 E1A-binding protein p400 (chains A)
MHHGTGPQNVQHQLQRSRACPGSEGEEQPAHPNPPPSPAAPFAPSASPSAPQSPSYQIQQ
LMNRSPATGQNVNITLQSVGPVVGGNQQITLAPLPLPSPTSPGFQFSAQPRRFEHGSPSY
IQVTSPLSQQVQTQSPTQPSPGPGQALQNVRAGAPGPGLGLCSSSPTGGFVDASVLVRQI
SLSPSSGGHFVFQDGSGLTQIAQGAQVQLQHPGTPITVRERRPSQPHTQSGGTIHHLGPQ
SPAAAGGAGLQPLASPSHITTANLPPQISSIIQGQLVQQQQVLQGPPLPRPLGFERTPGV
LLPGAGGAAGFGMTSPPPPTSPSRTAVPPGLSSLPLTSVGNTGMKKVPKKLEEIPPASPE
MAQMRKQCLDYHYQEMQALKEVFKEYLIELFFLQHFQGNMMDFLAFKKKHYAPLQAYLRQ
NDLDIEEEEEEEEEEEEKSEVINDEVKVVTGKDGQTGTPVAIATQLPPKVSAAFSSQQQP
FQQALAGSLVAGAGSTVETDLFKRQQAMPSTGMAEQSKRPRLEVGHQGVVFQHPGADAGV
PLQQLMPTAQGGMPPTPQAAQLAGQRQSQQQYDPSTGPPVQNAASLHTPLPQLPGRLPPA
GVPTAALSSALQFAQQPQVVEAQTQLQIPVKTQQPNVPIPAPPSSQLPIPPSQPAQLALH
VPTPGKVQVQASQLSSLPQMVASTRLPVDPAPPCPRPLPTSSTSSLAPVSGSGPGPSPAR
SSPVNRPSSATNKALSPVTSRTPGVVASAPTKPQSPAQNATSSQDSSQDTLTEQITLENQ
VHQRIAELRKAGLWSQRRLPKLQEAPRPKSHWDYLLEEMQWMATDFAQERRWKVAAAKKL
VRTVVRHHEEKQLREERGKKEEQSRLRRIAASTAREIECFWSNIEQVVEIKLRVELEEKR
KKALNLQKVSRRGKELRPKGFDALQESSLDSGMSGRKRKASISLTDDEVDDEEETIEEEE
ANEGVVDHQTELSNLAKEAELPLLDLMKLYEGAFLPSSQWPRPKPDGEDTSGEEDADDCP
GDRESRKDLVLIDSLFIMDQFKAAERMNIGKPNAKDIADVTAVAEAILPKGSARVTTSVK
FNAPSLLYGALRDYQKIGLDWLAKLYRKNLNGILADEAGLGKTVQIIAFFAHLACNEGNW
GPHLVVVRSCNILKWELELKRWCPGLKILSYIGSHRELKAKRQEWAEPNSFHVCITSYTQ
FFRGLTAFTRVRWKCLVIDEMQRVKGMTERHWEAVFTLQSQQRLLLIDSPLHNTFLELWT
MVHFLVPGISRPYLSSPLRAPSEESQDYYHKVVIRLHRVTQPFILRRTKRDVEKQLTKKY
EHVLKCRLSNRQKALYEDVILQPGTQEALKSGHFVNVLSILVRLQRICNHPGLVEPRHPG
SSYVAGPLEYPSASLILKALERDFWKEADLSMFDLIGLENKITRHEAELLSKKKIPRKLM
EEISTSAAPAARPAAAKLKASRLFQPVQYGQKPEGRTVAFPSTHPPRTAAPTTASAAPQG
PLRGRPPIATFSANPEAKAAAAPFQTSQASASAPRHQPASASSTAASPAHPAKLRAQTTA
QASTPGQPPPQPQAPSHAAGQSALPQRLVLPSQAQARLPSGEVVKIAQLASITGPQSRVA
QPETPVTLQFQGSKFTLSHSQLRQLTAGQPLQLQGSVLQIVSAPGQPYLRAPGPVVMQTV
SQAGAVHGALGSKPPAGGPSPAPLTPQVGVPGRVAVNALAVGEPGTASKPASPIGGPTQE
EKTRLLKERLDQIYLVNERRCSQAPVYGRDLLRICALPSHGRVQWRGSLDGRRGKEAGPA
HSYTSSSESPSELMLTLCRCGESLQDVIDRVAFVIPPVVAAPPSLRVPRPPPLYSHRMRI
LRQGLREHAAPYFQQLRQTTAPRLLQFPELRLVQFDSGKLEALAILLQKLKSEGRRVLIL
SQMILMLDILEMFLNFHYLTYVRIDENASSEQRQELMRSFNRDRRIFCAILSTHSRTTGI
NLVEADTVVFYDNDLNPVMDAKAQEWCDRIGRCKDIHIYRLVSGNSIEEKLLKNGTKDLI
REVAAQGNDYSMAFLTQRTIQELFEVYSPMDDAGFPVKAEEFVVLSQEPSVTETIAPKIA
RPFIEALKSIEYLEEDAQKSAQEGVLGPHTDALSSDSENMPCDEEPSQLEELADFMEQLT
PIEKYALNYLELFHTSIEQEKERNSEDAVMTAVRAWEFWNLKTLQEREARLRLEQEEAEL
LTYTREDAYSMEYVYEDVDGQTEVMPLWTPPTPPQDDSDIYLDSVMCLMYEATPIPEAKL
PPVYVRKERKRHKTDPSAAGRKKKQRHGEAVVPPRSLFDRATPGLLKIRREGKEQKKNIL
LKQQVPFAKPLPTFAKPTAEPGQDNPEWLISEDWALLQAVKQLLELPLNLTIVSPAHTPN
WDLVSDVVNSCSRIYRSSKQCRNRYENVIIPREEGKSKNNRPLRTSQIYAQDENATHTQL
YTSHFDLMKMTAGKRSPPIKPLLGMNPFQKNPKHASVLAESGINYDKPLPPIQVASLRAE
RIAKEKKALADQQKAQQPAVAQPPPPQPQPPPPPQQPPPPLPQPQAAGSQPPAGPPAVQP
QPQPQPQTQPQPVQAPAKAQPAITTGGSAAVLAGTIKTSVTGTSMPTGAVSGNVIVNTIA
GVPAATFQSINKRLASPVAPGALTTPGGSAPAQVVHTQPPPRAVGSPATATPDLVSMATT
QGVRAVTSVTASAVVTTNLTPVQTPARSLVPQVSQATGVQLPGKTITPAHFQLLRQQQQQ
QQQQQQQQQQQQQQQQQQQQQQQQTTTTSQVQVPQIQGQAQSPAQIKAVGKLTPEHLIKM
QKQKLQMPPQPPPPQAQSAPPQPTAQVQVQTSQPPQQQSPQLTTVTAPRPGALLTGTTVA
NLQVARLTRVPTSQLQAQGQMQTQAPQPAQVALAKPPVVSVPAAVVSSPGVTTLPMNVAG
ISVAIGQPQKAAGQTVVAQPVHMQQLLKLKQQAVQQQKAIQPQAAQGPAAVQQKITAQQI
TTPGAQQKVAYAAQPALKTQFLTTPISQAQKLAGAQQVQTQIQVAKLPQVVQQQTPVASI
QQVASASQQASPQTVALTQATAAGQQVQMIPAVTATAQVVQQKLIQQQVVTTASAPLQTP
GAPNPAQVPASSDSPSQQPKLQMRVPAVRLKTPTKPPCQ
Sequence of entity 2 (B), FASTA
>9CAC_2 Vacuolar protein sorting-associated protein 72 homolog (chains B)
MSLAGGRAPRKTAGNRLSGLLEAEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSD
FDIDEGDEPSSDGEAEEPRRKRRVVTKAYKEPLKSLRPRKVNTPAGSSQKAREEKALLPL
ELQDDGSDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITE
ELNLRSLETYERLEADKKKQVHKKRKCPGPIITYHSVTVPLVGEPGPKEENVDIEGLDPA
PSVSALTPHAGTGPVNPPARCSRTFITFSDDATFEEWFPQGRPPKVPVREVCPVTHRPAL
YRDPVTDIPYATARAFKIIREAYKKYITAHGLPPTASALGPGPPPPEPLPGSGPRALRQK
IVIK
Sequence of entity 3 (C), FASTA
>9CAC_3 Enhancer of polycomb homolog 1 (chains C)
MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEESEHHLQRAIS
AQQVYGEKRDNMVIPVPEAESNIAYYESIYPGEFKMPKQLIHIQPFSLDAEQPDYDLDSE
DEVFVNKLKKKMDICPLQFEEMIDRLEKGSGQQPVSLQEAKLLLKEDDELIREVYEYWIK
KRKNCRGPSLIPSVKQEKRDGSSTNDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRRD
LSRAVTILEMIKRREKSKRELLHLTLEIMEKRYNLGDYNGEIMSEVMAQRQPMKPTYAIP
IIPITNSSQFKHQEAMDVKEFKVNKQDKADLIRPKRKYEKKPKVLPSSAAATPQQTSPAA
LPVFNAKDLNQYDFPSSDEEPLSQVLSGSSEAEEDNDPDGPFAFRRKAGCQYYAPHLDQT
GNWPWTSPKDGGLGDVRYRYCLTTLTVPQRCIGFARRRVGRGGRVLLDRAHSDYDSVFHH
LDLEMLSSPQHSPVNQFANTSETNTSDKSFSKDLSQILVNIKSCRWRHFRPRTPSLHDSD
NDELSCRKLYRSINRTGTAQPGTQTCSTSTQSKSSSGSAHFAFTAEQYQQHQQQLALMQK
QQLAQIQQQQANSNSSTNTSQNLASNQQKSGFRLNIQGLERTLQGFVSKTLDSASAQFAA
SALVTSEQLMGFKMKDDVVLGIGVNGVLPASGVYKGLHLSSTTPTALVHTSPSTAGSALL
QPSNITQTSSSHSALSHQVTAANSATTQVLIGNNIRLTVPSSVATVNSIAPINARHIPRT
LSAVPSSALKLAAAANCQVSKVPSSSSVDSVPRENHESEKPALNNIADNTVAMEVT
Sequence of entity 4 (E, G, I), FASTA
>9CAC_4 RuvB-like 1 (chains E, G, I)
MKIEEVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQENAREACGVIVELIKSKK
MAGRAVLLAGPPGTGKTALALAIAQELGSKVPFCPMVGSEVYSTEIKKTEVLMENFRRAI
GLRIKETKEVYEGEVTELTPCETENPMGGYGKTISHVIIGLKTAKGTKQLKLDPSIFESL
QKERVEAGDVIYIEANSGAVKRQGRCDTYATEFDLEAEEYVPLPKGDVHKKKEIIQDVTL
HDLDVANARPQGGQDILSMMGQLMKPKKTEITDKLRGEINKVVNKYIDQGIAELVPGVLF
VDEVHMLDIECFTYLHRALESSIAPIVIFASNRGNCVIRGTEDITSPHGIPLDLLDRVMI
IRTMLYTPQEMKQIIKIRAQTEGINISEEALNHLGEIGTKTTLRYSVQLLTPANLLAKIN
GKDSIEKEHVEEISELFYDAKSSAKILADQQDKYMK
Sequence of entity 5 (F, H, J), FASTA
>9CAC_5 RuvB-like 2 (chains F, H, J)
MATVTATTKVPEIRDVTRIERIGAHSHIRGLGLDDALEPRQASQGMVGQLAARRAAGVVL
EMIREGKIAGRAVLIAGQPGTGKTAIAMGMAQALGPDTPFTAIAGSEIFSLEMSKTEALT
QAFRRSIGVRIKEETEIIEGEVVEIQIDRPATGTGSKVGKLTLKTTEMETIYDLGTKMIE
SLTKDKVQAGDVITIDKATGKISKLGRSFTRARDYDAMGSQTKFVQCPDGELQKRKEVVH
TVSLHEIDVINSRTQGFLALFSGDTGEIKSEVREQINAKVAEWREEGKAEIIPGVLFIDE
VHMLDIESFSFLNRALESDMAPVLIMATNRGITRIRGTSYQSPHGIPIDLLDRLLIVSTT
PYSEKDTKQILRIRCEEEDVEMSEDAYTVLTRIGLETSLRYAIQLITAASLVCRKRKGTE
VQVDDIKRVYSLFLDESRSTQYMKEYQDAFLFNELKGETMDTS
Sequence of entity 6 (K, L), FASTA
>9CAC_6 Actin, cytoplasmic 1 (chains K, L)
MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQS
KRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMT
QIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDL
AGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSY
ELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQ
EYDESGPSIVHRKCF
Sequence of entity 7 (M), FASTA
>9CAC_7 Actin-like protein 6A (chains M)
MSGGVYGGDEVGALVFDIGSYTVRAGYAGEDCPKVDFPTAIGMVVERDDGSTLMEIDGDK
GKQGGPTYYIDTNALRVPRENMEAISPLKNGMVEDWDSFQAILDHTYKMHVKSEASLHPV
LMSEAPWNTRAKREKLTELMFEHYNIPAFFLCKTAVLTAFANGRSTGLILDSGATHTTAI
PVHDGYVLQQGIVKSPLAGDFITMQCRELFQEMNIELVPPYMIASKEAVREGSPANWKRK
EKLPQVTRSWHNYMCNCVIQDFQASVLQVSDSTYDEQVAAQMPTVHYEFPNGYNCDFGAE
RLKIPEGLFDPSNVKGLSGNTMLGVSHVVTTSVGMCDIDIRPGLYGSVIVAGGNTLIQSF
TDRLNRELSQKTPPSMRLKLIANNTTVERRFSSWIGGSILASLGTFQQMWISKQEYEEGG
KQCVERKCP
Sequence of entity 8 (N), FASTA
>9CAC_8 DNA methyltransferase 1-associated protein 1 (chains N)
MATGADVRDILELGGPEGDAASGTISKKDIINPDKKKSKKSSETLTFKRPEGMHREVYAL
LYSDKKDAPPLLPSDTGQGYRTVKAKLGSKKVRPWKWMPFTNPARKDGAMFFHWRRAAEE
GKDYPFARFNKTVQVPVYSEQEYQLYLHDDAWTKAETDHLFDLSRRFDLRFVVIHDRYDH
QQFKKRSVEDLKERYYHICAKLANVRAVPGTDLKIPVFDAGHERRRKEQLERLYNRTPEQ
VAEEEYLLQELRKIEARKKEREKRSQDLQKLITAADTTAEQRRTERKAPKKKLPQKKEAE
KPAVPETAGIKFPDFKSAGVTLRSQRMKLPSSVGQKKIKALEQMLLELGVELSPTPTEEL
VHMFNELRSDLVLLYELKQACANCEYELQMLRHRHEALARAGVLGGPATPASGPGPASAE
PAVTEPGLGPDPKDTIIDVVGAPLTPNSRKRRESASSSSSVKKAKKP
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ADP | Adenosine-5'-diphosphate | C10 H15 N5 O10 P2 | 7 |
| ATP | Adenosine-5'-triphosphate | C10 H16 N5 O13 P3 | 1 |
| MG | Magnesium ion | Mg | 8 |
Primary citation
Structural divergence of H2A.Z-associated human chromatin remodelers SRCAP and TIP60. Park, G., Patel, A.B., Wu, C. et al. To be published.
Other PDB entries of the same protein (UniProt Q96L91), best resolution first:
- 9CAF 2.35 Å, Cryo-EM structure of the reconstituted TRRAP lobe of the human TIP60 complex (composite…
- 8QR1 2.4 Å, Cryo-EM structure of the human Tip60 complex
- 9C57 2.75 Å, Reconstituted P400 Subcomplex of the human TIP60 complex
- 9CAD 3.05 Å, Cryo-EM structure of the TRRAP lobe of the native human TIP60 complex (composite…
- 9CAE 3.07 Å, Cryo-EM structure of the reconstituted RuvBL lobe of the human TIP60 complex (composite…
- 8XVT 3.2 Å, The core subcomplex of human NuA4/TIP60 complex
- 8XVV 3.2 Å, The TRRAP module of human NuA4/TIP60 complex
- 9C6N 3.29 Å, ARP module of the human TIP60 complex
- 9C47 3.4 Å, TRRAP module of the human TIP60 complex
- 8QRI 3.5 Å, TRRAP and EP400 in the human Tip60 complex
- 9C62 5.28 Å, P400 subcomplex of the native human TIP60 complex
- 8XVG 9.4 Å, Structure of human NuA4/TIP60 complex
Browse structure collections
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