Golgi resident protein GCP60 (ACBD3) is a 528-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9H3P7.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 78.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 60% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (PubMed:11590181). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (PubMed:27009356)
Homodimer (PubMed:23572552). Interacts with the C-terminal cytoplasmic domain of giantin/GOLGB1 (PubMed:11590181). Interacts with PBR and PKA regulatory subunit RI-alpha. Does not interact with PKA regulatory subunit RI-beta nor PKA regulatory subunit RII-alpha (By similarity). Interacts (via Q domain) with PI4KB (via N-terminus) (PubMed:22124328, PubMed:22258260, PubMed:23572552,…
Golgi apparatus membrane, Mitochondrion
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5LZ1 | X-ray | 2.0 Å | A=364-528 |
| 6HLN | X-ray | 2.1 Å | A=364-528 |
| 6HMV | X-ray | 2.24 Å | A=364-528 |
| 6HM8 | X-ray | 2.28 Å | A=364-528 |
| 5TDQ | X-ray | 2.49 Å | A=367-528 |
| 6HLV | X-ray | 2.5 Å | A=364-528 |
| 5LZ6 | X-ray | 2.6 Å | A=364-528 |
| 6HLW | X-ray | 2.73 Å | A/C=364-528 |
| 6HLT | X-ray | 2.81 Å | A/C=364-528 |
| 5LZ3 | X-ray | 3.0 Å | A=364-528 |
| 2N72 | NMR | A=241-308 | |
| 2N73 | NMR | A=241-308 |
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