Diablo IAP-binding mitochondrial protein (DIABLO) is a 239-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9NR28.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 82.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 62% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 18% |
| Below 50 | Very low: often disordered regions | 11% |
What pLDDT means and how to read it
Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/BRUCE by inhibiting its binding to caspases (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106)
Homodimer (PubMed:10972280, PubMed:36758104, PubMed:36758105, PubMed:36758106). Interacts with BIRC2/c-IAP1 (via BIR3 domain) (PubMed:19153467). Interacts with BIRC6/BRUCE; inhibits BIRC6 activity (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Interacts with BIRC7/livin (PubMed:16729033). Interacts with XIAP/BIRC4 (via BIR3 domain) (PubMed:11140637, PubMed:21695558,…
Mitochondrion, Cytoplasm, cytosol
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1TW6 | X-ray | 1.71 Å | C/D=56-64 |
| 4TX5 | X-ray | 1.8 Å | A/B=56-239 |
| 1G73 | X-ray | 2.0 Å | A/B=56-217 |
| 1FEW | X-ray | 2.2 Å | A=56-239 |
| 1XB0 | X-ray | 2.2 Å | G/H/I/J/K/L=56-62 |
| 1OXQ | X-ray | 2.3 Å | F=56-64 |
| 3D9U | X-ray | 2.3 Å | B=56-61 |
| 3UIH | X-ray | 2.4 Å | P/Q=56-70 |
| 1XB1 | X-ray | 2.7 Å | G/H/I/J/K/L=56-62 |
| 3UIJ | X-ray | 2.7 Å | P/Q=56-70 |
| 6JX6 | X-ray | 2.81 Å | A/B/C/D=56-239 |
| 8ATO | EM | 3.0 Å | C/D=56-239 |
| 8E2I | EM | 3.04 Å | E/F=56-239 |
| 8E2J | EM | 3.44 Å | A/B=56-239 |
| 8AUW | EM | 7.2 Å | C/D=56-239 |
| 1G3F | NMR | B=56-64 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.