DNA polymerase kappa (POLK) is a 870-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9UBT6.
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The mean pLDDT of this model is 70.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 48% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 35% |
What pLDDT means and how to read it
DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity
Interacts with REV1 (By similarity). Forms a quaternary complex with REV1, MAD2L2 and REV3L, where REV3L-bound MAD2L2 and POLK are able to bind simultaneously to REV1 forming the stable translesion synthesis (TLS) machinery therefore bridging the inserter and extender polymerases (PubMed:23143872). Interacts with PCNA (PubMed:11784855)
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6CST | X-ray | 2.0 Å | A/B=1-526 |
| 1T94 | X-ray | 2.4 Å | A/B=68-526 |
| 5W2C | X-ray | 2.5 Å | A/B=1-526 |
| 4U6P | X-ray | 2.59 Å | A/B=1-526 |
| 4BA9 | X-ray | 2.73 Å | A/B/C/D/E/F=563-575 |
| 4U7C | X-ray | 2.8 Å | A/B=27-518 |
| 6BRX | X-ray | 2.8 Å | A/B=1-526 |
| 5W2A | X-ray | 2.9 Å | A/B=1-526 |
| 5T14 | X-ray | 3.0 Å | A/B=1-527 |
| 2OH2 | X-ray | 3.05 Å | A/B=19-526 |
| 6BS1 | X-ray | 3.15 Å | A/B=1-526 |
| 2W7O | X-ray | 3.16 Å | A/B=19-526 |
| 3IN5 | X-ray | 3.2 Å | A/B=19-526 |
| 4GK5 | X-ray | 3.21 Å | G=564-573 |
| 3PZP | X-ray | 3.34 Å | A/B=19-528 |
| 7NV0 | EM | 3.4 Å | A=1-870 |
| 2W7P | X-ray | 3.71 Å | A/B=19-526 |
| 7NV1 | EM | 6.4 Å | A=1-870 |
| 2LSI | NMR | B=562-577 |
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