CD2-associated protein (CD2AP) is a 639-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9Y5K6.
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The mean pLDDT of this model is 62.2 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 29% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 51% |
What pLDDT means and how to read it
Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation…
Homodimer. Interacts with F-actin, PKD2, NPHS1 and NPHS2. Interacts with WTIP. Interacts with DDN; interaction is direct. Interacts (via SH3 2 domain) with CBL (via phosphorylated C-terminus). Interacts with BCAR1/p130Cas (via SH3 domain). Interacts with MVB12A and ARHGAP17. Interacts with ANLN, CD2 and CBLB. Interacts with PDCD6IP and TSG101. Interacts with RIN3. Interacts directly with RET…
Cytoplasm, cytoskeleton, Cell projection, ruffle, Cell junction
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3U23 | X-ray | 1.11 Å | A=109-168 |
| 4X1V | X-ray | 1.58 Å | A=109-168 |
| 4WCI | X-ray | 1.65 Å | A/C/E=1-60 |
| 7DS6 | X-ray | 1.69 Å | C=496-507 |
| 2J6F | X-ray | 1.7 Å | A=1-62 |
| 3AA6 | X-ray | 1.9 Å | C=485-507 |
| 7DS8 | X-ray | 1.95 Å | C=485-495 |
| 3LK4 | X-ray | 1.99 Å | 0/3/6/9/C/F/I/L/O/R/U/X=475-503 |
| 2J6O | X-ray | 2.22 Å | A=1-62 |
| 2J6K | X-ray | 2.78 Å | A/B/C/D/E/F/G/H/I/J/K/L=1-62 |
| 2J7I | X-ray | 2.9 Å | A/B=1-62 |
| 2FEI | NMR | A=111-166 |
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