Sorting nexin-9 (SNX9) is a 595-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9Y5X1.
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The mean pLDDT of this model is 79.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 64% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 25% |
What pLDDT means and how to read it
Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton.…
Homodimer, and homooligomer. Heterodimer with SNX18. Interacts with ITCH. Interacts (via SH3 domain) with TNK2, WASL and ACTR3. Identified in a complex with TNK2 and clathrin heavy chains. Identified in a complex with the AP-2 complex, clathrin and DNM2. Interacts (via SH3 domain) with DNM1 and DNM2. Identified in an oligomeric complex containing DNM1 and SNX9. Interacts with FCHSD1 (By…
Cytoplasmic vesicle membrane, Cell membrane, Cytoplasmic vesicle, clathrin-coated vesicle, Golgi apparatus, trans-Golgi network, Cell projection, ruffle, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3DYT | X-ray | 2.08 Å | A=230-595 |
| 3LGE | X-ray | 2.2 Å | E/F/G/H=152-182 |
| 2RAJ | X-ray | 2.45 Å | A=204-595 |
| 2RAK | X-ray | 3.0 Å | A=204-595 |
| 2RAI | X-ray | 3.2 Å | A/B=204-595 |
| 3DYU | X-ray | 4.1 Å | A/B/C=230-595 |
| 7OJ9 | NMR | A=1-64 | |
| 9R4W | NMR | A=1-64 |
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