11YE: PDB entry 11YE

Curved structure of mPiezo1 in plasma membrane vesicles. Determined by electron microscopy at 3.7 Å resolution. Released 29 Apr 2026.

Method
Electron microscopy
Resolution
3.7 Å
Organism
Mus musculus
Chains
3
Atoms
29,295
Mol. weight
882.24 kDa
Released
29 Apr 2026

Explore 11YE in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

11YE contains 210 α-helices and 42 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains C, D and E: 70 helices, 14 β-strands

ElementResiduesLengthSheet
α-helix785-82440
α-helix826-83914
α-helix847-86418
α-helix900-9034
α-helix923-95028
α-helix976-9838
α-helix990-9978
α-helix1001-10033
α-helix1006-101510
α-helix1016-10205
α-helix1021-10233
α-helix1026-105126
α-helix1073-10808
α-helix1088-10903
α-helix1092-111221
α-helix1142-11443
α-helix1149-117628
α-helix1179-120123
α-helix1205-123026
α-helix1231-12333
α-helix1243-12486
α-helix1263-12675
α-helix1280-129112
α-helix1292-12954
α-helix1296-12994
α-helix1303-136462
α-helix1404-14074
α-helix1413-14153
α-helix1418-14203
α-helix1497-152327
α-helix1525-154723
α-helix1553-15586
α-helix1657-166913
α-helix1672-168514
α-helix1687-169913
α-helix1706-17138
α-helix1714-17185
α-helix1726-174722
α-helix1753-17553
α-helix1758-17614
α-helix1770-17745
α-helix1786-180318
α-helix1947-196721
α-helix1977-199620
α-helix2016-203924
α-helix2043-205917
α-helix2060-20645
α-helix2065-20684
α-helix2077-209822
α-helix2117-212711
α-helix2131-214313
α-helix2151-217424
α-helix2181-21844
α-helix2185-221430
β-strand221911
β-strand2226-223272
β-strand2240-224342
α-helix2245-22473
β-strand2248-225033
α-helix2252-226211
α-helix2267-22748
β-strand2281-228773
α-helix2291-22944
α-helix2298-231013
α-helix23141
β-strand2315-2324102
α-helix2327-23293
β-strand2335-2344102
α-helix2349-235810
β-strand2366-237274
β-strand2375-237843
α-helix23851
β-strand238613
α-helix23871
β-strand2399-2409114
β-strand2426-243494
β-strand2443-245083
β-strand245311
α-helix2466-248520
α-helix2489-24913
α-helix2492-24954
α-helix2501-251515
α-helix2519-253214
α-helix2536-25427

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Piezo-type mechanosensitive ion channel component 1C, D, Eprotein2561Mus musculusE2JF22 (AlphaFold model)
Sequence of entity 1 (C, D, E), FASTA
>11YE_1 Piezo-type mechanosensitive ion channel component 1 (chains C, D, E)
MEPHVLGAGLYWLLLPCTLLAASLLRFNALSLVYLLFLLLLPWLPGPSRHSIPGHTGRLL
RALLCLSLLFLVAHLAFQICLHTVPHLDQFLGQNGSLWVKVSQHIGVTRLDLKDIFNTTR
LVAPDLGVLLASSLCLGLCGRLTRKAGQSRRTQELQDDDDDDDDDDEDIDAAPAVGLKGA
PALATKRRLWLASRFRVTAHWLLMTSGRTLVIVLLALAGIAHPSAFSSIYLVVFLAICTW
WSCHFPLSPLGFNTLCVMVSCFGAGHLICLYCYQTPFIQDMLPPGNIWARLFGLKNFVDL
PNYSSPNALVLNTKHAWPIYVSPGILLLLYYTATSLLKLHKSCPSELRKETPREDEEHEL
ELDHLEPEPQARDATQGEMPMTTEPDLDNCTVHVLTSQSPVRQRPVRPRLAELKEMSPLH
GLGHLIMDQSYVCALIAMMVWSIMYHSWLTFVLLLWACLIWTVRSRHQLAMLCSPCILLY
GLTLCCLRYVWAMELPELPTTLGPVSLHQLGLEHTRYPCLDLGAMLLYLLTFWLLLRQFV
KEKLLKKQKVPAALLEVTVADTEPTQTQTLLRSLGELVTGIYVKYWIYVCAGMFIVVSFA
GRLVVYKIVYMFLFLLCLTLFQVYYTLWRKLLRVFWWLVVAYTMLVLIAVYTFQFQDFPT
YWRNLTGFTDEQLGDLGLEQFSVSELFSSILIPGFFLLACILQLHYFHRPFMQLTDLEHV
PPPGTRHPRWAHRQDAVSEAPLLEHQEEEEVFREDGQSMDGPHQATQVPEGTASKWGLVA
DRLLDLAASFSAVLTRIQVFVRRLLELHVFKLVALYTVWVALKEVSVMNLLLVVLWAFAL
PYPRFRPMASCLSTVWTCIIIVCKMLYQLKIVNPHEYSSNCTEPFPNNTNLQPLEINQSL
LYRGPVDPANWFGVRKGYPNLGYIQNHLQILLLLVFEAVVYRRQEHYRRQHQQAPLPAQA
VCADGTRQRLDQDLLSCLKYFINFFFYKFGLEICFLMAVNVIGQRMNFMVILHGCWLVAI
LTRRRREAIARLWPNYCLFLTLFLLYQYLLCLGMPPALCIDYPWRWSKAIPMNSALIKWL
YLPDFFRAPNSTNLISDFLLLLCASQQWQVFSAERTEEWQRMAGINTDHLEPLRGEPNPI
PNFIHCRSYLDMLKVAVFRYLFWLVLVVVFVAGATRISIFGLGYLLACFYLLLFGTTLLQ
KDTRAQLVLWDCLILYNVTVIISKNMLSLLSCVFVEQMQSNFCWVIQLFSLVCTVKGYYD
PKEMMTRDRDCLLPVEEAGIIWDSICFFFLLLQRRIFLSHYFLHVSADLKATALQASRGF
ALYNAANLKSINFHRQIEEKSLAQLKRQMKRIRAKQEKYRQSQASRGQLQSKDPQDPSQE
PGPDSPGGSSPPRRQWWRPWLDHATVIHSGDYFLFESDSEEEEEALPEDPRPAAQSAFQM
AYQAWVTNAQTVLRQRRERARQERAEQLASGGDLNPDVEPVDVPEDEMAGRSHMMQRVLS
TMQFLWVLGQATVDGLTRWLRAFTKHHRTMSDVLCAERYLLTQELLRVGEVRRGVLDQLY
VGEDEATLSGPVETRDGPSTASSGLGAEEPLSSMTDDTSSPLSTGYNTRSGSEEIVTDAG
DLQAGTSLHGSQELLANARTRMRTASELLLDRRLHIPELEEAERFEAQQGRTLRLLRAGY
QCVAAHSELLCYFIIILNHMVTASAASLVLPVLVFLWAMLTIPRPSKRFWMTAIVFTEVM
VVTKYLFQFGFFPWNSYVVLRRYENKPYFPPRILGLEKTDSYIKYDLVQLMALFFHRSQL
LCYGLWDHEEDRYPKDHCRSSVKDREAKEEPEAKLESQSETGTGHPKEPVLAGTPRDHIQ
GKGSIRSKDVIQDPPEDLKPRHTRHISIRFRRRKETPGPKGTAVMETEHEEGEGKETTER
KRPRHTQEKSKFRERMKAAGRRLQSFCVSLAQSFYQPLQRFFHDILHTKYRAATDVYALM
FLADIVDIIIIIFGFWAFGKHSAATDIASSLSDDQVPQAFLFMLLVQFGTMVIDRALYLR
KTVLGKLAFQVVLVVAIHIWMFFILPAVTERMFSQNAVAQLWYFVKCIYFALSAYQIRCG
YPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYA
NIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLIRSVVGVV
NQPIDVTVTLKLGGYEPLFTMSAQQPSIVPFTPQAYEELSQQFDPYPLAMQFISQYSPED
IVTAQIEGSSGALWRISPPSRAQMKQELYNGTADITLRFTWNFQRDLAKGGTVEYTNEKH
TLELAPNSTARRQLAQLLEGRPDQSVVIPHLFPKYIRAPNGPEANPVKQLQPDEEEDYLG
VRIQLRREQVGTGASGEQAGSRLEEELRRRLTETKASDFLEWWVIELQDCKADCNLLPMV
IFSDKVSPPSLGFLAGYGIVGLYVSIVLVVGKFVRGFFSEISHSIMFEELPCVDRILKLC
QDIFLVRETRELELEEELYAKLIFLYRSPETMIKWTRERES

Primary citation

Lipid composition and mechanical force underlie multi-modal regulation of Piezo1 gating. Vaisey, G., MacKinnon, R. Sci Adv (2026) 12:eaed7115-eaed7115. DOI 10.1126/sciadv.aed7115 · PubMed

Other PDB entries of the same protein (UniProt E2JF22 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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