Intermediate structure of mPIEZO1-S2472E. Determined by electron microscopy at 4.0 Å resolution. Released 1 Jan 2025.
Explore 8IXO in 3D Show helices and sheets RCSB PDB PDBe
8IXO contains 219 α-helices and 51 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 577-584 | 8 | |
| α-helix | 587-595 | 9 | |
| α-helix | 605-609 | 5 | |
| α-helix | 610-624 | 15 | |
| α-helix | 632-649 | 18 | |
| α-helix | 692-705 | 14 | |
| α-helix | 709-714 | 6 | |
| α-helix | 786-803 | 18 | |
| α-helix | 805-817 | 13 | |
| α-helix | 830-837 | 8 | |
| α-helix | 843-845 | 3 | |
| α-helix | 846-867 | 22 | |
| α-helix | 925-949 | 25 | |
| α-helix | 968-970 | 3 | |
| α-helix | 974-1005 | 32 | |
| α-helix | 1008-1022 | 15 | |
| α-helix | 1026-1051 | 26 | |
| α-helix | 1074-1079 | 6 | |
| α-helix | 1088-1090 | 3 | |
| α-helix | 1094-1112 | 19 | |
| α-helix | 1139-1144 | 6 | |
| α-helix | 1150-1158 | 9 | |
| α-helix | 1162-1174 | 13 | |
| α-helix | 1179-1193 | 15 | |
| α-helix | 1195-1199 | 5 | |
| α-helix | 1203-1232 | 30 | |
| α-helix | 1235-1241 | 7 | |
| α-helix | 1244-1248 | 5 | |
| α-helix | 1281-1296 | 16 | |
| α-helix | 1301-1314 | 14 | |
| α-helix | 1319-1362 | 44 | |
| α-helix | 1403-1407 | 5 | |
| α-helix | 1412-1414 | 3 | |
| α-helix | 1506-1523 | 18 | |
| α-helix | 1525-1543 | 19 | |
| α-helix | 1657-1668 | 12 | |
| α-helix | 1673-1686 | 14 | |
| α-helix | 1689-1701 | 13 | |
| α-helix | 1709-1713 | 5 | |
| α-helix | 1714-1718 | 5 | |
| α-helix | 1729-1747 | 19 | |
| α-helix | 1771-1774 | 4 | |
| α-helix | 1786-1802 | 17 | |
| α-helix | 1957-1965 | 9 | |
| α-helix | 1978-1993 | 16 | |
| α-helix | 1996-1998 | 3 | |
| α-helix | 2007-2012 | 6 | |
| α-helix | 2018-2040 | 23 | |
| α-helix | 2044-2060 | 17 | |
| α-helix | 2064-2068 | 5 | |
| α-helix | 2078-2099 | 22 | |
| α-helix | 2116-2127 | 12 | |
| α-helix | 2131-2142 | 12 | |
| α-helix | 2149-2174 | 26 | |
| α-helix | 2185-2213 | 29 | |
| α-helix | 2218 | 1 | |
| β-strand | 2219 | 1 | 6 |
| α-helix | 2220 | 1 | |
| β-strand | 2225-2232 | 8 | 7 |
| β-strand | 2237-2241 | 5 | 7 |
| α-helix | 2245-2247 | 3 | |
| β-strand | 2248-2250 | 3 | 8 |
| α-helix | 2251-2252 | 2 | |
| α-helix | 2253-2262 | 10 | |
| α-helix | 2267-2274 | 8 | |
| α-helix | 2278-2280 | 3 | |
| β-strand | 2281-2287 | 7 | 8 |
| β-strand | 2289 | 1 | 9 |
| α-helix | 2298-2310 | 13 | |
| β-strand | 2315 | 1 | 10 |
| β-strand | 2317-2324 | 8 | 7 |
| β-strand | 2335-2341 | 7 | 7 |
| β-strand | 2344 | 1 | 10 |
| α-helix | 2349-2358 | 10 | |
| β-strand | 2366-2372 | 7 | 9 |
| β-strand | 2375-2377 | 3 | 8 |
| β-strand | 2385-2386 | 2 | 8 |
| β-strand | 2399-2409 | 11 | 9 |
| α-helix | 2423-2425 | 3 | |
| β-strand | 2426-2434 | 9 | 9 |
| β-strand | 2443-2449 | 7 | 8 |
| β-strand | 2453 | 1 | 6 |
| α-helix | 2459-2462 | 4 | |
| α-helix | 2466-2469 | 4 | |
| α-helix | 2470-2474 | 5 | |
| α-helix | 2475-2483 | 9 | |
| α-helix | 2490-2492 | 3 | |
| α-helix | 2501-2516 | 16 | |
| α-helix | 2519-2534 | 16 | |
| α-helix | 2536-2542 | 7 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Piezo-type mechanosensitive ion channel component 1 | A, B, F | protein | 2547 | Mus musculus | E2JF22 (AlphaFold model) |
>8IXO_1 Piezo-type mechanosensitive ion channel component 1 (chains A, B, F) MEPHVLGAGLYWLLLPCTLLAASLLRFNALSLVYLLFLLLLPWLPGPSRHSIPGHTGRLL RALLCLSLLFLVAHLAFQICLHTVPHLDQFLGQNGSLWVKVSQHIGVTRLDLKDIFNTTR LVAPDLGVLLASSLCLGLCGRLTRKAGQSRRTQELQDDDDDDDDDDEDIDAAPAVGLKGA PALATKRRLWLASRFRVTAHWLLMTSGRTLVIVLLALAGIAHPSAFSSIYLVVFLAICTW WSCHFPLSPLGFNTLCVMVSCFGAGHLICLYCYQTPFIQDMLPPGNIWARLFGLKNFVDL PNYSSPNALVLNTKHAWPIYVSPGILLLLYYTATSLLKLHKSCPSELRKETPREDEEHEL ELDHLEPEPQARDATQGEMPMTTEPDLDNCTVHVLTSQSPVRQRPVRPRLAELKEMSPLH GLGHLIMDQSYVCALIAMMVWSIMYHSWLTFVLLLWACLIWTVRSRHQLAMLCSPCILLY GLTLCCLRYVWAMELPELPTTLGPVSLHQLGLEHTRYPCLDLGAMLLYLLTFWLLLRQFV KEKLLKKQKVPAALLEVTVADTEPTQTQTLLRSLGELVTGIYVKYWIYVCAGMFIVVSFA GRLVVYKIVYMFLFLLCLTLFQVYYTLWRKLLRVFWWLVVAYTMLVLIAVYTFQFQDFPT YWRNLTGFTDEQLGDLGLEQFSVSELFSSILIPGFFLLACILQLHYFHRPFMQLTDLEHV PPPGTRHPRWAHRQDAVSEAPLLEHQEEEEVFREDGQSMDGPHQATQVPEGTASKWGLVA DRLLDLAASFSAVLTRIQVFVRRLLELHVFKLVALYTVWVALKEVSVMNLLLVVLWAFAL PYPRFRPMASCLSTVWTCIIIVCKMLYQLKIVNPHEYSSNCTEPFPNNTNLQPLEINQSL LYRGPVDPANWFGVRKGYPNLGYIQNHLQILLLLVFEAVVYRRQEHYRRQHQQAPLPAQA VCADGTRQRLDQDLLSCLKYFINFFFYKFGLEICFLMAVNVIGQRMNFMVILHGCWLVAI LTRRRREAIARLWPNYCLFLTLFLLYQYLLCLGMPPALCIDYPWRWSKAIPMNSALIKWL YLPDFFRAPNSTNLISDFLLLLCASQQWQVFSAERTEEWQRMAGINTDHLEPLRGEPNPI PNFIHCRSYLDMLKVAVFRYLFWLVLVVVFVAGATRISIFGLGYLLACFYLLLFGTTLLQ KDTRAQLVLWDCLILYNVTVIISKNMLSLLSCVFVEQMQSNFCWVIQLFSLVCTVKGYYD PKEMMTRDRDCLLPVEEAGIIWDSICFFFLLLQRRIFLSHYFLHVSADLKATALQASRGF ALYNAANLKSINFHRQIEEKSLAQLKRQMKRIRAKQEKYRQSQASRGQLQSKDPQDPSQE PGPDSPGGSSPPRRQWWRPWLDHATVIHSGDYFLFESDSEEEEEALPEDPRPAAQSAFQM AYQAWVTNAQTVLRQRRERARQERAEQLASGGDLNPDVEPVDVPEDEMAGRSHMMQRVLS TMQFLWVLGQATVDGLTRWLRAFTKHHRTMSDVLCAERYLLTQELLRVGEVRRGVLDQLY VGEDEATLSGPVETRDGPSTASSGLGAEEPLSSMTDDTSSPLSTGYNTRSGSEEIVTDAG DLQAGTSLHGSQELLANARTRMRTASELLLDRRLHIPELEEAERFEAQQGRTLRLLRAGY QCVAAHSELLCYFIIILNHMVTASAASLVLPVLVFLWAMLTIPRPSKRFWMTAIVFTEVM VVTKYLFQFGFFPWNSYVVLRRYENKPYFPPRILGLEKTDSYIKYDLVQLMALFFHRSQL LCYGLWDHEEDRYPKDHCRSSVKDREAKEEPEAKLESQSETGTGHPKEPVLAGTPRDHIQ GKGSIRSKDVIQDPPEDLKPRHTRHISIRFRRRKETPGPKGTAVMETEHEEGEGKETTER KRPRHTQEKSKFRERMKAAGRRLQSFCVSLAQSFYQPLQRFFHDILHTKYRAATDVYALM FLADIVDIIIIIFGFWAFGKHSAATDIASSLSDDQVPQAFLFMLLVQFGTMVIDRALYLR KTVLGKLAFQVVLVVAIHIWMFFILPAVTERMFSQNAVAQLWYFVKCIYFALSAYQIRCG YPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYA NIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLIRSVVGVV NQPIDVTVTLKLGGYEPLFTMSAQQPSIVPFTPQAYEELSQQFDPYPLAMQFISQYSPED IVTAQIEGSSGALWRISPPSRAQMKQELYNGTADITLRFTWNFQRDLAKGGTVEYTNEKH TLELAPNSTARRQLAQLLEGRPDQSVVIPHLFPKYIRAPNGPEANPVKQLQPDEEEDYLG VRIQLRREQVGTGASGEQAGTKASDFLEWWVIELQDCKADCNLLPMVIFSDKVSPPSLGF LAGYGIVGLYVEIVLVVGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIFLVRETRELE LEEELYAKLIFLYRSPETMIKWTRERE
| ID | Name | Formula | Copies |
|---|---|---|---|
| PEE | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine | C41 H78 N O8 P | 3 |
| P5S | O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine | C42 H82 N O10 P | 6 |
| PLX | (9R,11S)-9-({[(1S)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2L… | C42 H89 N O8 P | 6 |
An intermediate open structure reveals the gating transition of the mechanically activated PIEZO1 channel. Liu, S., Yang, X., Chen, X. et al. Neuron (2025) 113:590. DOI 10.1016/j.neuron.2024.11.020 · PubMed
Other PDB entries of the same protein (UniProt E2JF22 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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