Structure of the mechanically activated ion channel Piezo1. Determined by electron microscopy at 3.8 Å resolution. Released 27 Dec 2017.
Explore 6BPZ in 3D Show helices and sheets RCSB PDB PDBe
6BPZ contains 141 α-helices and 42 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 1151-1158 | 8 | |
| α-helix | 1161-1172 | 12 | |
| α-helix | 1179-1192 | 14 | |
| α-helix | 1195-1198 | 4 | |
| α-helix | 1203-1231 | 29 | |
| α-helix | 1281-1297 | 17 | |
| α-helix | 1300-1305 | 6 | |
| α-helix | 1308-1314 | 7 | |
| α-helix | 1316-1363 | 48 | |
| α-helix | 1412-1414 | 3 | |
| α-helix | 1502-1510 | 9 | |
| α-helix | 1514-1518 | 5 | |
| α-helix | 1604-1618 | 15 | |
| α-helix | 1620-1639 | 20 | |
| α-helix | 1662-1666 | 5 | |
| α-helix | 1673-1685 | 13 | |
| α-helix | 1688-1702 | 15 | |
| α-helix | 1709-1713 | 5 | |
| α-helix | 1714-1718 | 5 | |
| α-helix | 1727-1746 | 20 | |
| α-helix | 1783-1802 | 20 | |
| α-helix | 1958-1960 | 3 | |
| α-helix | 1962-1966 | 5 | |
| α-helix | 1977-1994 | 18 | |
| α-helix | 2018-2039 | 22 | |
| α-helix | 2044-2062 | 19 | |
| α-helix | 2076-2099 | 24 | |
| α-helix | 2116-2126 | 11 | |
| α-helix | 2133-2141 | 9 | |
| α-helix | 2149-2174 | 26 | |
| α-helix | 2185-2187 | 3 | |
| α-helix | 2188-2192 | 5 | |
| α-helix | 2193-2210 | 18 | |
| β-strand | 2223-2232 | 10 | 1 |
| α-helix | 2236-2237 | 2 | |
| β-strand | 2239-2243 | 5 | 1 |
| β-strand | 2248-2250 | 3 | 2 |
| α-helix | 2251-2252 | 2 | |
| α-helix | 2253-2262 | 10 | |
| α-helix | 2267-2273 | 7 | |
| α-helix | 2278-2280 | 3 | |
| β-strand | 2281-2287 | 7 | 2 |
| β-strand | 2289 | 1 | 3 |
| α-helix | 2298-2310 | 13 | |
| β-strand | 2315-2325 | 11 | 1 |
| α-helix | 2327-2329 | 3 | |
| β-strand | 2335-2344 | 10 | 1 |
| α-helix | 2349-2356 | 8 | |
| α-helix | 2357-2359 | 3 | |
| β-strand | 2366-2372 | 7 | 3 |
| β-strand | 2375-2378 | 4 | 2 |
| β-strand | 2383 | 1 | 1 |
| β-strand | 2386 | 1 | 2 |
| β-strand | 2399-2409 | 11 | 3 |
| β-strand | 2426-2434 | 9 | 3 |
| β-strand | 2443-2450 | 8 | 2 |
| α-helix | 2451-2453 | 3 | |
| α-helix | 2467-2484 | 18 | |
| α-helix | 2501-2515 | 15 | |
| α-helix | 2522-2532 | 11 | |
| α-helix | 2536-2542 | 7 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Piezo-type mechanosensitive ion channel component 1,Piezo-type mechanosensitive ion channel… | A, B, C | protein | 1423 | Mus musculus | E2JF22 (AlphaFold model) |
>6BPZ_1 Piezo-type mechanosensitive ion channel component 1,Piezo-type mechanosensitive ion channel component 1,mouse Piezo1,Piezo-type mechanosensitive ion channel component 1,Piezo-type mechanosensitive ion channel component 1 (chains A, B, C) PNPIPNFIHCRSYLDMLKVAVFRYLFWLVLVVVFVAGATRISIFGLGYLLACFYLLLFGT TLLQKDTRAQLVLWDCLILYNVTVIISKNMLSLLSCVFVEQMQSNFCWVIQLFSLVCTVK GYYDPKEMMTRDRDCLLPVEEAGIIWDSICFFFLLLQRRIFLSHYFLHVSADLKATALQA SRGFALYNAANLKSINFHRQIEEKSLAQLKRQMKRIRAKQEKYRQSQASRGQLQSKDPQD PSQEPGPDSPGGSSPPRRQWWRPWLDHATVIHSGDYFLFESDSEEEEEALPEDPRPAAQS AFQMAYQAWVTNAQTVLRQRRERARQERAEQLASGGDLNPDVEPVDVPEDEMAGRSHMMQ RVLSTMQFLWVLGQATVDGLTRWLRAFTKHHRTMSDVLCAERYLLTQELLRVGEVRRGVL DQLYVGEDEATLSGPVETRDGPSTASSGLGAEEPLSSMTDDXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPELEEAERFEAQQGRTLRLL RAGYQCVAAHSELLCYFIIILNHMVTASAASLVLPVLVFLWAMLTIPRPSKRFWMTAIVF TEVMVVTKYLFQFGFFPWNSYVVLRRYENKPYFPPRILGLEKTDSYIKYDLVQLMALFFH RSQLLCYGLWDHEEDRYPKDHCRSSVKDREAKEEPEAKLESQSETGTGHPKEPVLAGTPR DHIQGKGSIRSKDVIQDPPEDLKPRHTRHISIRFRRRKETPGPKGTAVMETEHEEGEGKE TTERKRPRHTQEKSKFRERMKAAGRRLQSFCVSLAQSFYQPLQRFFHDILHTKYRAATDV YALMFLADIVDIIIIIFGFWAFGKHSAATDIASSLSDDQVPQAFLFMLLVQFGTMVIDRA LYLRKTVLGKLAFQVVLVVAIHIWMFFILPAVTERMFSQNAVAQLWYFVKCIYFALSAYQ IRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVE DIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLIRSV VGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIVPFTPQAYEELSQQFDPYPLAMQFISQY SPEDIVTAQIEGSSGALWRISPPSRAQMKQELYNGTADITLRFTWNFQRDLAKGGTVEYT NEKHTLELAPNSTARRQLAQLLEGRPDQSVVIPHLFPKYIRAPNGPEANPVKQLQPDEEE DYLGVRIQLRREQVGTGASGEQAGTKASDFLEWWVIELQDCKADCNLLPMVIFSDKVSPP SLGFLAGYGIVGLYVSIVLVVGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIFLVRET RELELEEELYAKLIFLYRSPETMIKWTREREKKLGAPLEVLFQ
Structure of the mechanically activated ion channel Piezo1. Saotome, K., Murthy, S.E., Kefauver, J.M. et al. Nature (2018) 554:481-486. DOI 10.1038/nature25453 · PubMed
Other PDB entries of the same protein (UniProt E2JF22 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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