1EDN: Human endothelin-1

Human endothelin-1. Determined by X-ray diffraction at 2.18 Å resolution. Released 15 Oct 1995.

Method: X-ray diffraction
Resolution: 2.18 Å
Organism: Homo sapiens
Chains: 1
Atoms: 171
Mol. weight: 2.5 kDa
Released: 15 Oct 1995

Explore 1EDN in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1EDN contains 1 α-helix and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	8-10	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Endothelin-1	A	protein	21	Homo sapiens	P05305 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1EDN_1 ENDOTHELIN-1 (chains A)
CSCSSLMDKECVYFCHLDIIW

Primary citation

The crystal structure of human endothelin. Janes, R.W., Peapus, D.H., Wallace, B.A. Nat Struct Biol (1994) 1:311-319. DOI 10.1038/nsb0594-311 · PubMed

Other PDB entries of the same protein (UniProt P05305 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1T7H 1.13 Å, X-ray structure of [Lys(-2)-Arg(-1)-des(17-21)]-endothelin-1 peptide
6DK5 1.85 Å, The X-ray crystal structure of human endothelin-1, a polypeptide hormone regulator of…
5GLH 2.8 Å, Human endothelin receptor type-B in complex with ET-1
8IY5 2.8 Å, ETB-Gi complex bound to endothelin-1
8XVE 3.0 Å, Cryo-EM structure of ETBR bound with BQ3020
8HCQ 3.01 Å, Cryo-EM structure of endothelin1-bound ETAR-Gq complex
8IY6 3.13 Å, ETB-Gi complex bound to Endotheline-1, focused on receptor
8XGR 3.2 Å, ETB-eGt complex bound to endothelin-1
8XWP 3.21 Å, Cryo-EM structure of ET-1 bound ETBR-DNGI complex
8XVH 3.26 Å, Cryo-EM structure of ETBR bound with Endothelin1
8XVI 3.32 Å, Cryo-EM structure of ETAR bound with Endothelin1
8HCX 3.5 Å, Cryo-EM structure of Endothelin1-bound ETBR-Gq complex

Browse structure collections

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