6DK5: Endothelin-1

Name: PDB 6DK5: The X-ray crystal structure of human endothelin-1, a polypeptide hormone regulator of blood pressure
Published: 2019-01-02
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: hormone

The X-ray crystal structure of human endothelin-1, a polypeptide hormone regulator of blood pressure. Determined by X-ray diffraction at 1.85 Å resolution. Released 2 Jan 2019.

Method: X-ray diffraction
Resolution: 1.85 Å
Organism: Homo sapiens
Chains: 2
Atoms: 358
Mol. weight: 5 kDa
Released: 2 Jan 2019

Explore 6DK5 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6DK5 contains 2 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	9-12	4

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	9-14	6

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Endothelin-1	A, B	protein	21	Homo sapiens	P05305 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>6DK5_1 Endothelin-1 (chains A, B)
CSCSSLMDKECVYFCHLDIIW

Primary citation

The X-ray crystal structure of human endothelin 1, a polypeptide hormone regulator of blood pressure. McPherson, A., Larson, S.B. Acta Crystallogr F Struct Biol Commun (2019) 75:47-53. DOI 10.1107/S2053230X18016011 · PubMed

Other PDB entries of the same protein (UniProt P05305 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1T7H 1.13 Å, X-ray structure of [Lys(-2)-Arg(-1)-des(17-21)]-endothelin-1 peptide
1EDN 2.18 Å, Human endothelin-1
5GLH 2.8 Å, Human endothelin receptor type-B in complex with ET-1
8IY5 2.8 Å, ETB-Gi complex bound to endothelin-1
8XVE 3.0 Å, Cryo-EM structure of ETBR bound with BQ3020
8HCQ 3.01 Å, Cryo-EM structure of endothelin1-bound ETAR-Gq complex
8IY6 3.13 Å, ETB-Gi complex bound to Endotheline-1, focused on receptor
8XGR 3.2 Å, ETB-eGt complex bound to endothelin-1
8XWP 3.21 Å, Cryo-EM structure of ET-1 bound ETBR-DNGI complex
8XVH 3.26 Å, Cryo-EM structure of ETBR bound with Endothelin1
8XVI 3.32 Å, Cryo-EM structure of ETAR bound with Endothelin1
8HCX 3.5 Å, Cryo-EM structure of Endothelin1-bound ETBR-Gq complex

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