1GXE: Myosin binding protein C, cardiac-type

Central domain of cardiac myosin binding protein C. Determined by solution NMR. Released 12 Jun 2003.

Method: Solution NMR
Organism: HOMO SAPIENS
Chains: 1
Atoms: 1,002
Mol. weight: 15.4 kDa
Released: 12 Jun 2003

Explore 1GXE in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1GXE contains 0 α-helices and 9 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 0 helices, 9 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	1
β-strand	18-21	4	2
β-strand	30-32	3	3
β-strand	36	1	1
β-strand	40-46	7	2
β-strand	86-90	5	3
β-strand	93-97	5	3
β-strand	107-114	8	2
β-strand	119-128	10	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Myosin binding protein C, cardiac-type	A	protein	139	HOMO SAPIENS	Q14896 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1GXE_1 MYOSIN BINDING PROTEIN C, CARDIAC-TYPE (chains A)
MHHHHHHSSRQEPPKIHLDCPGRIPDTIVVVAGNKLRLDVPISGDPAPTVIWQKAITQGN
KAPARPAPDAPEDTGDSDEWVFDKKLLCETEGRVRVETTKDRSIFTVEGAEKEDEGVYTV
TVKNPVGEDQVNLTVKVID

Primary citation

Structure, Stability and Dynamics of the Central Domain of Cardiac Myosin Binding Protein C (Mybp-C): Implications for Multidomain Assembly and Causes for Cardiomyopathy. Idowu, S., Gautel, M., Perkins, S. et al. J Mol Biol (2003) 329:745. DOI 10.1016/S0022-2836(03)00425-X · PubMed

Other PDB entries of the same protein (UniProt Q14896 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3CX2 1.3 Å, Crystal structure of the C1 domain of cardiac isoform of myosin binding protein-C at 1.3A
2V6H 1.55 Å, Crystal structure of the C1 domain of cardiac myosin binding protein-C
7LRG 6.1 Å, Filamentous actin decorated with human cardiac myosin binding protein C C2 domain
8G4L 6.4 Å, Cryo-EM structure of the human cardiac myosin filament
7TIJ 8.0 Å, Cardiac F-actin decorated with regulatory M-domain of cardiac myosin binding protein C
7TIT 8.0 Å, Cardiac thin filament decorated with regulatory M-domain of cardiac myosin binding…
7TJ7 8.0 Å, Cardiac thin filament decorated with C1 Ig-domain and regulatory M-domain of cardiac…
6G2T 9.0 Å, human cardiac myosin binding protein C C1 Ig-domain bound to native cardiac thin filament
6CXI 11.0 Å, Cardiac thin filament decorated with C0C1 fragment of cardiac myosin binding protein C…
6CXJ 11.0 Å, Cardiac thin filament decorated with C0C1 fragment of cardiac myosin binding protein C…
1PD6 The NMR structure of domain C2 of human cardiac Myosin Binding Protein C
2AVG NMR structure of cC1 domain from Human Cardiac Myosin Binding Protein C

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