1L4D: Plasminogen

Crystal structure of microplasminogen-streptokinase alpha domain complex. Determined by X-ray diffraction at 2.3 Å resolution. Released 11 Dec 2002.

Method: X-ray diffraction
Resolution: 2.3 Å
Organisms: Homo sapiens, Streptococcus dysgalactiae subsp. equisimilis
Chains: 2
Atoms: 3,016
Mol. weight: 40.9 kDa
Released: 11 Dec 2002

Explore 1L4D in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1L4D contains 16 α-helices and 31 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 14 helices, 20 β-strands

Element	Residues	Length	Sheet
α-helix	546-547	2
α-helix	558-559	2
β-strand	566-567	2	1
α-helix	568-569	2
β-strand	576-581	6	2
β-strand	586-594	9	2
β-strand	597-601	5	2
α-helix	602-606	5
α-helix	611-613	3
β-strand	614-618	5	2
β-strand	622	1	3
β-strand	631-640	10	2
β-strand	647-652	6	2
α-helix	655-658	4
α-helix	664-665	2
β-strand	666	1	1
α-helix	667-669	3
α-helix	674-675	2
β-strand	679-684	6	1
β-strand	696	1	3
β-strand	698-705	8	1
α-helix	707-710	4
β-strand	724-727	4	1
β-strand	736	1	4
α-helix	740	1
β-strand	744-749	6	1
β-strand	752-759	8	1
α-helix	760	1
β-strand	766	1	4
β-strand	767	1	5
β-strand	770	1	5
β-strand	772-776	5	1
α-helix	777-780	4
α-helix	781-790	10

Chain B: 2 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	17-26	10	6
β-strand	32-33	2	6
β-strand	38-41	4	6
β-strand	42-43	2	7
β-strand	70-71	2	7
β-strand	73-75	3	8
α-helix	76-89	14
β-strand	98-103	6	6
β-strand	108-111	4	6
α-helix	115	1
β-strand	116-117	2	6
β-strand	124-126	3	8
β-strand	134-145	12	6

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Plasminogen	A	protein	249	Homo sapiens	P00747 (AlphaFold model)
Streptokinase	B	protein	122	Streptococcus dysgalactiae subsp. equisimilis	P00779 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1L4D_1 PLASMINOGEN (chains A)
APSFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAA
HCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLEPTRKDIALLKLSSPAVITDKV
IPACLPSPNYVVADRTECFITGWGETQGTFGAGLLKEAQLPVIENKVCNRYEFLNGRVQS
TELCAGHLAGGTDSCQGDAGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVT
WIEGVMRNN

Sequence of entity 2 (B), FASTA

>1L4D_2 STREPTOKINASE (chains B)
NNSQLVVSVAGTVEGTNQDISLKFFEIDLTSRPASKPFATDSGAMPHKLEKADLLKAIQE
QLIANVHSNDDYFEVIDFASDATITDRNGKVYFADKDGSVTLPTQPVQEFLLSGHVRVRP
YK

Primary citation

Effects of deletion of streptokinase residues 48-59 on plasminogen activation. Wakeham, N., Terzyan, S., Zhai, P. et al. Protein Eng (2002) 15:753-761. DOI 10.1093/protein/15.9.753 · PubMed

Other PDB entries of the same protein (UniProt P00747 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5UGG 1.2 Å, Protease Inhibitor
6D3Y 1.32 Å, Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin…
5UGD 1.38 Å, Protease Inhibitor
6D40 1.43 Å, Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin…
8F7U 1.47 Å, Macrocyclic Plasmin Inhibitor
7UAH 1.57 Å, Macrocyclic plasmin inhibitor
8F7V 1.65 Å, Macrocyclic plasmin inhibitor
5HPG 1.66 Å, Structure and ligand determinants of the recombinant kringle 5 domain of human plasminogen
1KRN 1.67 Å, Structure of kringle 4 at 4C temperature and 1.67 Å resolution
6OG4 1.7 Å, plasminogen binding group A streptococcal M protein
1KI0 1.75 Å, The X-ray Structure of Human Angiostatin
4CIK 1.78 Å, plasminogen kringle 1 in complex with inhibitor

Browse structure collections

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