1U4P: Human RANTES mutant K45E

Crystal Structure of human RANTES mutant K45E. Determined by X-ray diffraction at 1.7 Å resolution. Released 9 Nov 2004.

Method: X-ray diffraction
Resolution: 1.7 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,371
Mol. weight: 15.78 kDa
Released: 9 Nov 2004

Explore 1U4P in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1U4P contains 8 α-helices and 10 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and B: 4 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	6	1	1
β-strand	8-10	3	2
α-helix	18-20	3
α-helix	21-23	3
β-strand	24-29	6	3
α-helix	30-31	2
β-strand	39-43	5	3
β-strand	48-51	4	3
α-helix	56-63	8

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Small inducible cytokine A5	A, B	protein	68	Homo sapiens	P13501 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>1U4P_1 Small inducible cytokine A5 (chains A, B)
SPYSSDTTPCCFAYIARPLPRAHIKEYFYTSGKCSNPAVVFVTRENRQVCANPEKKWVRE
YINSLEMS

Primary citation

The X-ray structure of RANTES: heparin-derived disaccharides allows the rational design of chemokine inhibitors. Shaw, J.P., Johnson, Z., Borlat, F. et al. Structure (2004) 12:2081-2093. DOI 10.1016/j.str.2004.08.014 · PubMed

Other PDB entries of the same protein (UniProt P13501 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5COY 1.44 Å, Crystal structure of CC chemokine 5 (CCL5)
6STK 1.52 Å, Crystal structure of the CC-chemokine 5 (CCL5) E66S mutation
1B3A 1.6 Å, Total chemical synthesis and high-resolution crystal structure of the potent anti-HIV…
1EQT 1.6 Å, Met-rantes
6AEZ 1.63 Å, Crystal structure of human CCL5 trimer
2VXW 1.7 Å, Structural and Functional Studies of the Potent Anti-HIV Chemokine Variant P2-RANTES
1U4L 2.0 Å, human RANTES complexed to heparin-derived disaccharide I-S
1U4M 2.0 Å, human RANTES complexed to heparin-derived disaccharide III-S
1U4R 2.2 Å, Crystal Structure of human RANTES mutant 44-AANA-47
5UIW 2.2 Å, Crystal Structure of CC Chemokine Receptor 5 (CCR5) in complex with high potency HIV…
5L2U 2.28 Å, Oligomer crystal structure of CC chemokine 5 (CCL5)
5DNF 2.55 Å, Crystal structure of CC chemokine 5 (CCL5) oligomer in complex with heparin

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