C-C motif chemokine 5 (CCL5) is a 91-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P13501.
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The mean pLDDT of this model is 88.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 65% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 17% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and…
Homo and heterooligomers with other chemokines. Interacts with the brown dog tick evasin-4
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5COY | X-ray | 1.44 Å | A/B=27-91 |
| 6STK | X-ray | 1.52 Å | A/B=24-91 |
| 1B3A | X-ray | 1.6 Å | A/B=25-91 |
| 1EQT | X-ray | 1.6 Å | A/B=25-91 |
| 6AEZ | X-ray | 1.63 Å | A/B/C=24-91 |
| 1U4P | X-ray | 1.7 Å | A/B=24-91 |
| 2VXW | X-ray | 1.7 Å | A/B/C/D=33-91 |
| 1U4L | X-ray | 2.0 Å | A/B=24-91 |
| 1U4M | X-ray | 2.0 Å | A/B=24-91 |
| 1U4R | X-ray | 2.2 Å | A/B/C/D=24-91 |
| 5UIW | X-ray | 2.2 Å | B=33-91 |
| 5L2U | X-ray | 2.28 Å | A/B/C/D/E/F/G/H/I=27-91 |
| 5DNF | X-ray | 2.55 Å | A/B/C/D/E/F/G/H/I=27-91 |
| 6LOG | X-ray | 2.55 Å | A=24-91 |
| 7F1R | EM | 3.0 Å | R=24-91 |
| 5CMD | X-ray | 3.09 Å | A/B/C/D/E/F=27-91 |
| 7O7F | EM | 3.15 Å | I=23-91 |
| 6C6D | X-ray | 5.5 Å | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T=27-91 |
| 1HRJ | NMR | A/B=24-91 | |
| 1RTN | NMR | A/B=24-91 |
Showing 20 of 23 experimental structures (best resolution first).
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