1V6R: Endothelin-1 with its C-terminal Folding

Solution Structure of Endothelin-1 with its C-terminal Folding. Determined by solution NMR. Released 16 Mar 2004.

Method: Solution NMR
Chains: 1
Atoms: 171
Mol. weight: 2.5 kDa
Released: 16 Mar 2004

Explore 1V6R in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1V6R contains 1 α-helix and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	10-13	4

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Endothelin-1	A	protein	21		P05305 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1V6R_1 Endothelin-1 (chains A)
CSCSSLMDKECVYFCHLDIIW

Primary citation

Distributed Computing and NMR Constraint-Based High-Resolution Structure Determination: Applied for Bioactive Peptide Endothelin-1 To Determine C-Terminal Folding. Takashima, H., Mimura, N., Ohkubo, T. et al. J Am Chem Soc (2004) 126:4504-4505. DOI 10.1021/ja031637w · PubMed

Other PDB entries of the same protein (UniProt P05305 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1T7H 1.13 Å, X-ray structure of [Lys(-2)-Arg(-1)-des(17-21)]-endothelin-1 peptide
6DK5 1.85 Å, The X-ray crystal structure of human endothelin-1, a polypeptide hormone regulator of…
1EDN 2.18 Å, Human endothelin-1
5GLH 2.8 Å, Human endothelin receptor type-B in complex with ET-1
8IY5 2.8 Å, ETB-Gi complex bound to endothelin-1
8XVE 3.0 Å, Cryo-EM structure of ETBR bound with BQ3020
8HCQ 3.01 Å, Cryo-EM structure of endothelin1-bound ETAR-Gq complex
8IY6 3.13 Å, ETB-Gi complex bound to Endotheline-1, focused on receptor
8XGR 3.2 Å, ETB-eGt complex bound to endothelin-1
8XWP 3.21 Å, Cryo-EM structure of ET-1 bound ETBR-DNGI complex
8XVH 3.26 Å, Cryo-EM structure of ETBR bound with Endothelin1
8XVI 3.32 Å, Cryo-EM structure of ETAR bound with Endothelin1

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