2B5I: Cytokine receptor complex

cytokine receptor complex. Determined by X-ray diffraction at 2.3 Å resolution. Released 29 Nov 2005.

Method: X-ray diffraction
Resolution: 2.3 Å
Organism: Homo sapiens
Chains: 4
Atoms: 5,463
Mol. weight: 89.97 kDa
Ligands: NAG
Released: 29 Nov 2005

Explore 2B5I in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2B5I contains 28 α-helices and 52 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 11 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	7-28	22
α-helix	36-39	4
α-helix	43	1
β-strand	44	1	1
α-helix	45	1
β-strand	47	1	2
α-helix	53-56	4
α-helix	57-60	4
α-helix	63-70	8
α-helix	82-97	16
α-helix	105-106	2
β-strand	107	1	2
α-helix	108	1
β-strand	112	1	1
α-helix	114-132	19

Chain B: 6 helices, 16 β-strands

Element	Residues	Length	Sheet
β-strand	7-12	6	3
β-strand	17-23	7	3
β-strand	33-39	7	4
β-strand	46-49	4	4
β-strand	51-52	2	3
β-strand	58-63	6	3
β-strand	78-84	7	4
β-strand	91-98	8	4
α-helix	100-102	3
β-strand	104	1	3
α-helix	106-109	4
β-strand	110-117	8	5
β-strand	122-127	6	5
α-helix	133-135	3
β-strand	139-146	8	6
α-helix	156-157	2
β-strand	158-160	3	6
β-strand	166-169	4	5
α-helix	172-173	2
β-strand	177-186	10	6
α-helix	194-200	7
β-strand	201-204	4	6

Chain C: 6 helices, 16 β-strands

Element	Residues	Length	Sheet
α-helix	35-38	4
β-strand	39-43	5	7
β-strand	47-51	5	7
β-strand	64-69	6	8
α-helix	76-77	2
β-strand	78-79	2	8
β-strand	83-86	4	7
β-strand	89-96	8	7
α-helix	97-99	3
β-strand	106-111	6	8
β-strand	119-124	6	8
α-helix	126-128	3
β-strand	130-131	2	7
α-helix	132-135	4
β-strand	136-144	9	9
β-strand	147-153	7	9
β-strand	162-169	8	10
β-strand	176-180	5	10
β-strand	185-188	4	9
β-strand	197-204	8	10
α-helix	214-221	8
β-strand	222-223	2	10

Chain D: 5 helices, 16 β-strands

Element	Residues	Length	Sheet
α-helix	7-9	3
β-strand	13-16	4	11
β-strand	20	1	12
α-helix	21	1
β-strand	25-27	3	13
β-strand	34-36	3	14
α-helix	37	1
β-strand	43-45	3	13
β-strand	46	1	15
β-strand	55	1	15
β-strand	61-63	3	14
β-strand	104	1	12
α-helix	105-108	4
α-helix	117-118	2
β-strand	119-120	2	13
β-strand	126-131	6	11
β-strand	136-139	4	16
β-strand	144-146	3	11
β-strand	147-149	3	17
β-strand	154-156	3	17
β-strand	161-164	4	16

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Interleukin-2	A	protein	133	Homo sapiens	P60568 (AlphaFold model)
Interleukin-2 receptor beta chain	B	protein	214	Homo sapiens	P14784 (AlphaFold model)
Cytokine receptor common gamma chain	C	protein	199	Homo sapiens	P31785 (AlphaFold model)
Interleukin-2 receptor alpha chain	D	protein	217	Homo sapiens	P01589 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2B5I_1 Interleukin-2 (chains A)
APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLE
EELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNR
WITFCQSIISTLT

Sequence of entity 2 (B), FASTA

>2B5I_2 Interleukin-2 receptor beta chain (chains B)
AVQGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWQQTCELLPVSQASWAC
NLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETH
RCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEF
QVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDT

Sequence of entity 3 (C), FASTA

>2B5I_3 Cytokine receptor common gamma chain (chains C)
PLPEVQCFVFNVEYMNCTWQSSSEPQPTNLTLHYWYKNSDNDKVQKCSHYLFSEEITSGC
QLQKKEIHLYQTFVVQLQDPREPRRQATQMLKLQNLVIPWAPENLTLHKLSESQLELNWN
NRFLNHCLEHLVQYRTDWDHSWTEQSVDYRHKFSLPSVDGQKRYTFRVRSRFNPLCGSAQ
HWSEWSHPIHWGSNTSKEN

Sequence of entity 4 (D), FASTA

>2B5I_4 Interleukin-2 receptor alpha chain (chains D)
ELCDDDPPEIPHATFKAMAYKEGTMLNCECKRGFRRIKSGSLYMLCTGNSSHSSWDNQCQ
CTSSATRQTTKQVTPQPEEQKERKTTEMQSPMQPVDQASLPGHCREPPPWENEATERIYH
FVVGQMVYYQCVQGYRALHRGPAESVCKMTHGKTRWTQPQLICTGEMETSQFPGEEKPQA
SPEGRPESETSCLVTTTDFQIQTEMAATMETSIFTTE

Ligands and cofactors

ID	Name	Formula	Copies
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose	C8 H15 N O6	2

Primary citation

Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors. Wang, X., Rickert, M., Garcia, K.C. Science (2005) 310:1159-1163. DOI 10.1126/science.1117893 · PubMed

Other PDB entries of the same protein (UniProt P60568 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8SOZ 1.64 Å, Structure of the complex formed by human interleukin-2 and scFv 602
8SOW 1.71 Å, Structure of the complex formed by human interleukin-2 and scFv F10
7M2G 1.79 Å, INTERLEUKIN-2 (human) mutant P65K, C125S
4NEJ 1.92 Å, Small molecular fragment bound to crystal contact interface of Interleukin-2
4NEM 1.93 Å, Small molecular fragment bound to crystal contact interface of Interleukin-2
1M48 1.95 Å, Crystal Structure of Human IL-2 Complexed with (R)-N-[2-[1-(Aminoiminomethyl)-3-piperidin…
5LQB 1.95 Å, Complex structure of human IL2 mutant, Proleukin, with Fab fragment of NARA1 antibody
1M47 1.99 Å, Crystal Structure of Human Interleukin-2
1M49 2.0 Å, Crystal Structure of Human Interleukin-2 Complexed with SP-1985
1M4B 2.15 Å, Crystal Structure of Human Interleukin-2 K43C Covalently Modified at C43 with…
1M4A 2.18 Å, Crystal Structure of Human Interleukin-2 Y31C Covalently Modified at C31 with…
1NBP 2.2 Å, Crystal Structure Of Human Interleukin-2 Y31C Covalently Modified At C31 With…

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