2D7M: 14th Filamin domain from human Filamin C

Solution structure of the 14th Filamin domain from human Filamin C. Determined by solution NMR. Released 24 May 2006.

Method: Solution NMR
Organism: Homo sapiens
Chains: 1
Atoms: 826
Mol. weight: 11.75 kDa
Released: 24 May 2006

Explore 2D7M in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2D7M contains 1 α-helix and 10 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 10 β-strands

Element	Residues	Length	Sheet
α-helix	11-13	3
β-strand	14-17	4	1
β-strand	26-27	2	2
β-strand	32-38	7	1
β-strand	46-51	6	2
β-strand	57	1	2
β-strand	60-64	5	1
β-strand	70-74	5	1
β-strand	80-88	9	2
β-strand	92	1	2
β-strand	98-103	6	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Filamin-C	A	protein	115	Homo sapiens	Q14315 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2D7M_1 Filamin-C (chains A)
GSSGSSGAHDASKVRASGPGLNASGIPASLPVEFTIDARDAGEGLLTVQILDPEGKPKKA
NIRDNGDGTYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASSGPSSG

Primary citation

Solution structure of the 14th Filamin domain from human Filamin C. Tomizawa, T., Kigawa, T., Koshiba, S. et al. To be published.

Other PDB entries of the same protein (UniProt Q14315 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1V05 1.43 Å, Dimerization of human Filamin C: crystal structure of the domain 24
7OUU 1.47 Å, Crystal structure of human filamin C domains 14-15
7P0E 1.6 Å, Crystal structure of human filamin C domains 14-15 cardiovascular disease causing…
7OUV 1.8 Å, Crystal structure of human filamin C domains 14-15 cardiovascular disease causing…
2NQC 2.05 Å, Crystal structure of ig-like domain 23 from human filamin C
3V8O 2.8 Å, Human Filamin C Ig - like Domains 4 and 5
8PA0 2.85 Å, cvHsp (HspB7) C131S alpha-crystallin domain - filamin C (FLNC) domain 24 complex
4MGX 3.16 Å, Crystal structure of human filamin C domains 4-5 and GPIB alpha cytoplasmic domain complex
2D7N Solution structure of the 16th Filamin domain from human Filamin C
2D7O Solution structure of the 17th Filamin domain from human Filamin C
2D7P Solution structure of the 22th Filamin domain from human Filamin C
2D7Q Solution structure of the 23th Filamin domain from human Filamin C

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