2EYY: CT10-Regulated Kinase isoform I

CT10-Regulated Kinase isoform I. Determined by solution NMR. Released 10 Nov 2006.

Method: Solution NMR
Organism: Homo sapiens
Chains: 1
Atoms: 1,617
Mol. weight: 22.89 kDa
Released: 10 Nov 2006

Explore 2EYY in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2EYY contains 3 α-helices and 13 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 13 β-strands

Element	Residues	Length	Sheet
β-strand	14	1	1
α-helix	20-27	8
β-strand	34	1	2
β-strand	37-39	3	1
β-strand	47-51	5	1
β-strand	58-63	6	1
β-strand	88-89	2	1
α-helix	97-103	7
β-strand	116	1	2
α-helix	126-128	3
β-strand	135-138	4	3
β-strand	150	1	3
β-strand	158-166	9	3
β-strand	169-173	5	3
β-strand	179-182	4	3
β-strand	188	1	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
v-crk sarcoma virus CT10 oncogene homolog isoform a	A	protein	204	Homo sapiens	P46108 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2EYY_1 v-crk sarcoma virus CT10 oncogene homolog isoform a (chains A)
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY
IINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR
SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG
MIPVPYVEKYRPASASVSALIGGN

Primary citation

Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK. Kobashigawa, Y., Sakai, M., Naito, M. et al. Nat Struct Mol Biol (2007) 14:503-510. DOI 10.1038/nsmb1241 · PubMed

Other PDB entries of the same protein (UniProt P46108 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5UL6 1.45 Å, The molecular mechanisms by which NS1 of the 1918 Spanish influenza A virus hijack host…
6ATV 1.75 Å, The molecular mechanisms by which NS1 of the 1918 Spanish influenza A virus hijack host…
1JU5 Ternary complex of an Crk SH2 domain, Crk-derived phophopeptide, and Abl SH3 domain by…
2DVJ phosphorylated Crk-II
2EYV SH2 domain of CT10-Regulated Kinase
2EYW N-terminal SH3 domain of CT10-Regulated Kinase
2EYX C-Terminal SH3 domain of CT10-Regulated Kinase
2EYZ CT10-Regulated Kinase isoform II
2MS4 Cyclophilin a complexed with a fragment of crk-ii

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