2EYZ: CT10-Regulated Kinase isoform II

CT10-Regulated Kinase isoform II. Determined by solution NMR. Released 10 Nov 2006.

Method: Solution NMR
Organism: Homo sapiens
Chains: 1
Atoms: 2,394
Mol. weight: 33.88 kDa
Released: 10 Nov 2006

Explore 2EYZ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2EYZ contains 4 α-helices and 20 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 20 β-strands

Element	Residues	Length	Sheet
α-helix	22-25	4
β-strand	35-36	2	1
β-strand	48-54	7	1
β-strand	56-61	6	1
β-strand	89	1	2
β-strand	92	1	2
α-helix	97-101	5
β-strand	117	1	1
β-strand	136-139	4	3
β-strand	158-163	6	3
β-strand	169-173	5	3
β-strand	179-183	5	3
β-strand	187-189	3	3
α-helix	216-217	2
β-strand	219	1	4
β-strand	222	1	4
β-strand	246	1	5
α-helix	247-249	3
β-strand	258	1	5
β-strand	260	1	6
β-strand	262	1	6
β-strand	265-269	5	7
β-strand	275-279	5	7
β-strand	282-285	4	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
v-crk sarcoma virus CT10 oncogene homolog isoform a	A	protein	304	Homo sapiens	P46108 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2EYZ_1 v-crk sarcoma virus CT10 oncogene homolog isoform a (chains A)
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY
IINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR
SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG
MIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYA
RVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPE
EDFS

Primary citation

Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK. Kobashigawa, Y., Sakai, M., Naito, M. et al. Nat Struct Mol Biol (2007) 14:503-510. DOI 10.1038/nsmb1241 · PubMed

Other PDB entries of the same protein (UniProt P46108 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5UL6 1.45 Å, The molecular mechanisms by which NS1 of the 1918 Spanish influenza A virus hijack host…
6ATV 1.75 Å, The molecular mechanisms by which NS1 of the 1918 Spanish influenza A virus hijack host…
1JU5 Ternary complex of an Crk SH2 domain, Crk-derived phophopeptide, and Abl SH3 domain by…
2DVJ phosphorylated Crk-II
2EYV SH2 domain of CT10-Regulated Kinase
2EYW N-terminal SH3 domain of CT10-Regulated Kinase
2EYX C-Terminal SH3 domain of CT10-Regulated Kinase
2EYY CT10-Regulated Kinase isoform I
2MS4 Cyclophilin a complexed with a fragment of crk-ii

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