2GTG: Human Saposin C

Crystal Structure of Human Saposin C. Determined by X-ray diffraction at 2.4 Å resolution. Released 25 Jul 2006.

Method: X-ray diffraction
Resolution: 2.4 Å
Organism: Homo sapiens
Chains: 1
Atoms: 621
Mol. weight: 9.31 kDa
Released: 25 Jul 2006

Explore 2GTG in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2GTG contains 4 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 0 β-strands

Element	Residues	Length
α-helix	4-20	17
α-helix	25-35	11
α-helix	41-63	23
α-helix	68-74	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Proactivator polypeptide	A	protein	83	Homo sapiens	P07602 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2GTG_1 Proactivator polypeptide (chains A)
MDSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSI
LSILLEEVSPELVCSMLHLCSGT

Primary citation

Crystal structures of saposins A and C. Ahn, V.E., Leyko, P., Alattia, J.R. et al. Protein Sci (2006) 15:1849-1857. DOI 10.1110/ps.062256606 · PubMed

Other PDB entries of the same protein (UniProt P07602 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3BQP 1.3 Å, Crystal Structure of Human Saposin D (orthorhombic)
9I63 1.65 Å, Synthetic Human Saposin D glycoprotein
4UEX 1.8 Å, Structure of human Saposin A at lysosomal pH
4DDJ 1.9 Å, Crystal structure of saposin A in complex with lauryldimethylamine-N-oxide (LDAO)
2DOB 2.0 Å, Crystal Structure of Human Saposin A
3BQQ 2.0 Å, Crystal Structure of Human Saposin D (triclinic)
2RB3 2.1 Å, Crystal Structure of Human Saposin D
4V2O 2.13 Å, Structure of saposin B in complex with chloroquine
1N69 2.2 Å, Crystal structure of human saposin B
6SLR 2.38 Å, Structure of saposin B in complex with atovaquone
2QYP 2.45 Å, Orthorhombic Crystal Structure of Human Saposin C Dimer in Open Conformation
2R0R 2.5 Å, Crystal Structure of Human Saposin D variant SapD K9E

Browse structure collections

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