2K0F: Calmodulin

Calmodulin complexed with calmodulin-binding peptide from smooth muscle myosin light chain kinase. Determined by solution NMR. Released 10 Jun 2008.

Method: Solution NMR
Organism: Homo sapiens
Chains: 2
Atoms: 1,281
Mol. weight: 19.1 kDa
Ligands: CA
Released: 10 Jun 2008

Explore 2K0F in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2K0F contains 9 α-helices and 4 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	2-15	14
β-strand	22-23	2	1
α-helix	25-35	11
α-helix	41-51	11
β-strand	59-60	2	1
α-helix	61-69	9
α-helix	77-88	12
β-strand	96	1	2
α-helix	98-108	11
α-helix	114-124	11
β-strand	132	1	2
α-helix	134-140	7

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	2-18	17

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
calmodulin	A	protein	148	Homo sapiens	P0DP23 (AlphaFold model)
19-mer peptide from Myosin light chain kinase	B	protein	19		P11799 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2K0F_1 calmodulin (chains A)
ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGN
GTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEE
VDEMIREADIDGDGQVNYEEFVQMMTAK

Sequence of entity 2 (B), FASTA

>2K0F_2 19-mer peptide from Myosin light chain kinase (chains B)
RRKWQKTGHAVRAIGRLSS

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	4

Primary citation

A coupled equilibrium shift mechanism in calmodulin-mediated signal transduction. Gsponer, J., Christodoulou, J., Cavalli, A. et al. Structure (2008) 16:736-746. DOI 10.1016/j.str.2008.02.017 · PubMed

Other PDB entries of the same protein (UniProt P0DP23 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9MXD 1.17 Å, Human E104A calmodulin:MLCK RM20 complex
7BF1 1.24 Å, Ca2+-Calmodulin in complex with peptide from brain-type creatine kinase in extended 1:2…
6XXX 1.25 Å, 1.25 Angstrom crystal structure of Ca/CaM A102V:RyR2 peptide complex
4DJC 1.35 Å, 1.35 A crystal structure of the NaV1.5 DIII-IV-Ca/CaM complex
7BF2 1.43 Å, Ca2+-Calmodulin in complex with human muscle form creatine kinase peptide in extended…
2F3Y 1.45 Å, Calmodulin/IQ domain complex
2W73 1.45 Å, High-resolution structure of the complex between calmodulin and a peptide from…
4LZX 1.5 Å, Complex of IQCG and Ca2+-free CaM
5V03 1.58 Å, A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole…
9MVW 1.58 Å, Crystal structure of S101F calmodulin - CaM:RM20 analog complex
2F3Z 1.6 Å, Calmodulin/IQ-AA domain complex
6M7H 1.6 Å, Structure of calmodulin with KN93

Browse structure collections

About this viewer

MolViewer shows 2K0F directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.