2R28: The complex Structure of Calmodulin

The complex Structure of Calmodulin Bound to a Calcineurin Peptide. Determined by X-ray diffraction at 1.86 Å resolution. Released 1 Jul 2008.

Method: X-ray diffraction
Resolution: 1.86 Å
Organism: Homo sapiens
Chains: 4
Atoms: 2,803
Mol. weight: 39.64 kDa
Ligands: CA
Released: 1 Jul 2008

Explore 2R28 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2R28 contains 16 α-helices and 8 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	9-20	12
β-strand	28	1	1
α-helix	30-39	10
α-helix	46-56	11
β-strand	64	1	1
α-helix	66-93	28
β-strand	100-101	2	2
α-helix	103-112	10
α-helix	119-129	11
β-strand	137-138	2	2
α-helix	139-145	7

Chain B: 7 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	7-20	14
β-strand	28	1	3
α-helix	30-39	10
α-helix	46-56	11
β-strand	64	1	3
α-helix	66-93	28
β-strand	101	1	4
α-helix	103-112	10
α-helix	122-129	8
β-strand	137	1	4
α-helix	139-147	9

Chain C: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	397-409	13

Chain D: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	394-410	17

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Calmodulin	A, B	protein	149	Homo sapiens	P0DP23 (AlphaFold model)
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	C, D	protein	25	Homo sapiens	Q08209 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>2R28_1 Calmodulin (chains A, B)
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK

Sequence of entity 2 (C, D), FASTA

>2R28_2 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (chains C, D)
AAARKEVIRNKIRAIGKMARVFSVL

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	8

Primary citation

The complex structure of calmodulin bound to a calcineurin peptide. Ye, Q., Wang, H., Zheng, J. et al. Proteins (2008) 73:19-27. DOI 10.1002/prot.22032 · PubMed

Other PDB entries of the same protein (UniProt P0DP23 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9MXD 1.17 Å, Human E104A calmodulin:MLCK RM20 complex
7BF1 1.24 Å, Ca2+-Calmodulin in complex with peptide from brain-type creatine kinase in extended 1:2…
6XXX 1.25 Å, 1.25 Angstrom crystal structure of Ca/CaM A102V:RyR2 peptide complex
4DJC 1.35 Å, 1.35 A crystal structure of the NaV1.5 DIII-IV-Ca/CaM complex
7BF2 1.43 Å, Ca2+-Calmodulin in complex with human muscle form creatine kinase peptide in extended…
2F3Y 1.45 Å, Calmodulin/IQ domain complex
2W73 1.45 Å, High-resolution structure of the complex between calmodulin and a peptide from…
4LZX 1.5 Å, Complex of IQCG and Ca2+-free CaM
5V03 1.58 Å, A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole…
9MVW 1.58 Å, Crystal structure of S101F calmodulin - CaM:RM20 analog complex
2F3Z 1.6 Å, Calmodulin/IQ-AA domain complex
6M7H 1.6 Å, Structure of calmodulin with KN93

Browse structure collections

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