3IVF: Talin head FERM domain

Crystal structure of the talin head FERM domain. Determined by X-ray diffraction at 1.94 Å resolution. Released 18 Aug 2010.

Method: X-ray diffraction
Resolution: 1.94 Å
Organism: Mus musculus
Chains: 1
Atoms: 3,455
Mol. weight: 42.93 kDa
Released: 18 Aug 2010

Explore 3IVF in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3IVF contains 19 α-helices and 22 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 19 helices, 22 β-strands

Element	Residues	Length	Sheet
β-strand	4-10	7	1
β-strand	13-19	7	1
β-strand	24	1	2
α-helix	25-33	9
α-helix	37-40	4
α-helix	44-46	3
β-strand	47-51	5	1
α-helix	56-58	3
β-strand	60-61	2	1
α-helix	62-63	2
β-strand	67	1	2
α-helix	68-71	4
β-strand	78-83	6	1
β-strand	85-91	7	3
β-strand	97-103	7	3
β-strand	107	1	4
α-helix	108-118	11
α-helix	124-126	3
β-strand	127-130	4	3
β-strand	179	1	4
α-helix	181-183	3
β-strand	190-195	6	3
α-helix	196-197	2
β-strand	200	1	5
β-strand	205	1	5
α-helix	209-224	16
α-helix	232-247	16
α-helix	262-264	3
α-helix	268-270	3
α-helix	275-285	11
α-helix	291-304	14
β-strand	311-318	8	6
β-strand	325-332	8	6
β-strand	336-341	6	6
β-strand	347-352	6	6
α-helix	353-355	3
β-strand	358-362	5	6
β-strand	365-369	5	6
α-helix	371-373	3
β-strand	378-381	4	6
α-helix	385-397	13

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Talin-1	A	protein	371	Mus musculus	P26039 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>3IVF_1 Talin-1 (chains A)
MVALSLKISIGNVVKTMQFEPSTMVYDACRMIRERIPEALAGPPNDFGLFLSDDDPKKGI
WLEAGKALDYYMLRNGDTMEYRKKQRPLKIRMLDGTVKTIMVDDSKTVTDMLMTICARIG
ITNHDEYSLVRELMEEKKDDELNWLDHGRTLREQGVEEHETLLLRRKFFYSDQNVDSRDP
VQLNLLYVQARDDILNGSHPVSFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKE
YVKQKGERKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVPRL
LGITKECVMRVDEKTKEVIQEWSLTNIKRWAASPKSFTLDFGDYQDGYYSVQTTEGEQIA
QLIAGYIDIIL

Primary citation

The Structure of the talin head reveals a novel extended conformation of the FERM domain. Elliott, P.R., Goult, B.T., Kopp, P.M. et al. Structure (2010) 18:1289-1299. DOI 10.1016/j.str.2010.07.011 · PubMed

Other PDB entries of the same protein (UniProt P26039 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9SR0 1.49 Å, Mouse vinculin head domain 1 (VD1) (residues 2-258) with A50I mutation in complex with…
4W8P 1.5 Å, Crystal structure of RIAM TBS1 in complex with talin R7R8 domains
9DZ5 1.74 Å, Crystal structure of integrin beta-2 tail bound to the FERM-folded talin head domain…
7V1A 1.84 Å, Stapled TBS peptide from RIAM bound to talin R7R8 domains
3DYJ 1.85 Å, Crystal Structure of the R11R12 Domains of Talin
8FSE 1.9 Å, Crystal structure of integrin beta-2 tail bound to the FERM-folded talin head domain
3S90 1.97 Å, Human vinculin head domain Vh1 (residues 1-252) in complex with murine talin (VBS33;…
5IC0 1.97 Å, Structural analysis of a talin triple domain module
8FTB 1.97 Å, Crystal structure of integrin beta-2 tail bound to the FERM-folded talin head domain…
2X0C 2.0 Å, Crystal Structure of the R7R8 domains of Talin
4F7G 2.05 Å, Crystal structure of talin autoinhibition complex
1T01 2.06 Å, Vinculin complexed with the VBS1 helix from talin

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