A mutant human Prolactin receptor antagonist H27A in complex with the extracellular domain of the human prolactin receptor. Determined by X-ray diffraction at 2.0 Å resolution. Released 29 Sept 2010.
Explore 3N06 in 3D Show helices and sheets RCSB PDB PDBe
3N06 contains 19 α-helices and 17 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 15-44 | 30 | |
| α-helix | 50-54 | 5 | |
| α-helix | 69-74 | 6 | |
| α-helix | 77-90 | 14 | |
| α-helix | 92-103 | 12 | |
| α-helix | 110-137 | 28 | |
| α-helix | 148-150 | 3 | |
| α-helix | 153-157 | 5 | |
| α-helix | 161-195 | 35 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 2-4 | 3 | |
| β-strand | 8-13 | 6 | 1 |
| β-strand | 14 | 1 | 2 |
| β-strand | 20-25 | 6 | 1 |
| α-helix | 26-27 | 2 | |
| β-strand | 35-42 | 8 | 3 |
| β-strand | 49-50 | 2 | 3 |
| β-strand | 61-64 | 4 | 1 |
| α-helix | 66-68 | 3 | |
| β-strand | 75-83 | 9 | 3 |
| β-strand | 86-89 | 4 | 3 |
| α-helix | 90-92 | 3 | |
| β-strand | 93-95 | 3 | 3 |
| α-helix | 97-99 | 3 | |
| β-strand | 101 | 1 | 2 |
| α-helix | 103-106 | 4 | |
| β-strand | 107-114 | 8 | 4 |
| α-helix | 120-121 | 2 | |
| β-strand | 122-128 | 7 | 4 |
| α-helix | 129-130 | 2 | |
| β-strand | 142-149 | 8 | 5 |
| β-strand | 157-162 | 6 | 5 |
| β-strand | 166-169 | 4 | 4 |
| β-strand | 177-186 | 10 | 5 |
| α-helix | 190-197 | 8 | |
| β-strand | 198-201 | 4 | 5 |
| α-helix | 202-203 | 2 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Prolactin | A | protein | 186 | Homo sapiens | P01236 (AlphaFold model) |
| Prolactin receptor | B | protein | 210 | Homo sapiens | P16471 (AlphaFold model) |
>3N06_1 Prolactin (chains A) MLRDLFDRAVVLSAYIHNLSSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQ QMNQKDFLSLIVSILRSWNEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLERMELI VSQVHPETKENEIYPVWSGLPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRI IHNNNC
>3N06_2 Prolactin receptor (chains B) MLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMHECPDYITGGPN SCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPEDRK PYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYLV QVRCKPDHGYWSAWSPATFIQIPSDFTMND
Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation. Kulkarni, M.V., Tettamanzi, M.C., Murphy, J.W. et al. J Biol Chem (2010) 285:38524-38533. DOI 10.1074/jbc.M110.172072 · PubMed
Other PDB entries of the same protein (UniProt P01236 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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