3R3M: FAF1 UBX domain

Crystal structure of the FAF1 UBX domain. Determined by X-ray diffraction at 3.0 Å resolution. Released 22 Jun 2011.

Method: X-ray diffraction
Resolution: 3.0 Å
Organism: Homo sapiens
Chains: 4
Atoms: 2,763
Mol. weight: 40.07 kDa
Ligands: PO4
Released: 22 Jun 2011

Explore 3R3M in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3R3M contains 9 α-helices and 28 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	573-579	7	3
β-strand	585-591	7	3
β-strand	595	1	4
α-helix	597-606	10
β-strand	613-617	5	3
β-strand	622-623	2	3
α-helix	624-626	3
β-strand	632	1	4
β-strand	641-648	8	3

Chain B: 3 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	573-579	7	1
α-helix	584	1
β-strand	585-591	7	1
β-strand	595	1	2
α-helix	596-604	9
β-strand	613-618	6	1
β-strand	621-623	3	1
α-helix	624-626	3
β-strand	632	1	2
β-strand	641-648	8	1

Chains C and D: 2 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	573-579	7	5
β-strand	585-591	7	5
β-strand	595	1	6
α-helix	597-605	9
β-strand	613-617	5	5
β-strand	622-623	2	5
α-helix	624-626	3
β-strand	632	1	6
β-strand	641-648	8	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
FAS-associated factor 1	A, B, C, D	protein	85	Homo sapiens	Q9UNN5 (AlphaFold model)

Sequence of entity 1 (A, B, C, D), FASTA

>3R3M_1 FAS-associated factor 1 (chains A, B, C, D)
MSENAEPVSKLRIRTPSGEFLERRFLASNKLQIVFDFVASKGFPWDEYKLLSTFPRRDVT
QLDPNKSLLEVKLFPQETLFLEAKE

Ligands and cofactors

ID	Name	Formula	Copies
PO4	Phosphate ion	O4 P	3

Primary citation

Hierarchical Binding of Cofactors to the AAA ATPase p97. Hanzelmann, P., Buchberger, A., Schindelin, H. Structure (2011) 19:833-843. DOI 10.1016/j.str.2011.03.018 · PubMed

Other PDB entries of the same protein (UniProt Q9UNN5 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7FGN 1.2 Å, The crystal structure of the FAF1 UBL1
3QX1 1.6 Å, Crystal structure of FAF1 UBX domain
3E21 1.73 Å, Crystal structure of FAF-1 UBA Domain
3QQ8 2.0 Å, Crystal structure of p97-N in complex with FAF1-UBX
3QWZ 2.0 Å, Crystal structure of FAF1 UBX-p97N-domain complex
3QC8 2.2 Å, Crystal Structure of FAF1 UBX Domain In Complex with p97/VCP N Domain Reveals The…
7FGM 2.2 Å, The complex crystals structure of the FAF1 UBL1_L-Hsp70 NBD with ADP and phosphate
3QCA 2.9 Å, Crystal Structure of FAF1 UBX Domain In Complex with p97/VCP N Domain Reveals The…
8KG2 3.1 Å, Crystal structure of p97-N/D1 hexamer in complex with FAF1-UBX domain
9YW2 3.27 Å, Complex structure of human p97 bound to Faf1 and Ufd1 (NTD focused)
11TA 3.58 Å, Cryo-EM structure of substrate engaged p97-Ufd1-NPL4-Faf1 complex (motor focused)
11VE 3.85 Å, Cryo-EM structure of substrate engaged p97-Ufd1-NPL4-Faf1 complex (State1)

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