FAS-associated factor 1 (FAF1) is a 650-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9UNN5.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 77.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 25% |
| 70 to 90 | Confident: backbone generally right | 54% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 17% |
What pLDDT means and how to read it
Ubiquitin-binding protein (PubMed:19722279). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (PubMed:26842564). Potentiates but cannot initiate FAS-induced apoptosis (By similarity)
Interacts with CDT1 and ATPase VCP/p97 (PubMed:26842564). Interacts (via UBA domain) with FAS (via death domain) (PubMed:10462485). Interacts (via UBA domain) with NLRP12 (via DAPIN/PYRIN domain) (PubMed:21978668)
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7FGN | X-ray | 1.2 Å | A=100-174 |
| 3QX1 | X-ray | 1.6 Å | A/B=571-650 |
| 3E21 | X-ray | 1.73 Å | A=5-47 |
| 3QQ8 | X-ray | 2.0 Å | B=568-650 |
| 3QWZ | X-ray | 2.0 Å | B=571-650 |
| 3QC8 | X-ray | 2.2 Å | B=571-650 |
| 7FGM | X-ray | 2.2 Å | B=91-171 |
| 3QCA | X-ray | 2.9 Å | A/B/C/D=571-650 |
| 3R3M | X-ray | 3.0 Å | A/B/C/D=568-650 |
| 8KG2 | X-ray | 3.1 Å | M/N/O/P/Q/R/S/T/U/V/W/X=575-650 |
| 9YW2 | EM | 3.27 Å | H=1-650 |
| 11TA | EM | 3.58 Å | M/O=481-650 |
| 11VE | EM | 3.85 Å | M/O=481-650 |
| 1H8C | NMR | A=569-650 | |
| 2DZM | NMR | A=99-191 | |
| 2EC4 | NMR | A=325-495 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.