4GOW: Ca2+/CaM:Kv7.4 (KCNQ4) B helix complex

Crystal Structure of Ca2+/CaM:Kv7.4 (KCNQ4) B helix complex. Determined by X-ray diffraction at 2.6 Å resolution. Released 12 Dec 2012.

Method: X-ray diffraction
Resolution: 2.6 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,360
Mol. weight: 24.71 kDa
Ligands: CA
Released: 12 Dec 2012

Explore 4GOW in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4GOW contains 9 α-helices and 4 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	526-548	23

Chain D: 8 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	6-19	14
β-strand	26-27	2	1
α-helix	29-38	10
α-helix	45-55	11
β-strand	63-64	2	1
α-helix	65-74	10
α-helix	83-92	10
β-strand	100	1	2
α-helix	102-112	11
α-helix	118-128	11
β-strand	136	1	2
α-helix	138-145	8

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Calmodulin	D	protein	144	Homo sapiens	P0DP23 (AlphaFold model)
Potassium voltage-gated channel subfamily KQT member 4	A	protein	72	Homo sapiens	P56696 (AlphaFold model)

Sequence of entity 1 (D), FASTA

>4GOW_1 Calmodulin (chains D)
QLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGT
IDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVD
EMIREADIDGDGQVNYEEFVQMMT

Sequence of entity 2 (A), FASTA

>4GOW_2 Potassium voltage-gated channel subfamily KQT member 4 (chains A)
TVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQT
RVDQIVGRGPGD

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	4

Primary citation

Structure of a Ca(2+)/CaM:Kv7.4 (KCNQ4) B-helix complex provides insight into M current modulation. Xu, Q., Chang, A., Tolia, A. et al. J Mol Biol (2013) 425:378-394. DOI 10.1016/j.jmb.2012.11.023 · PubMed

Other PDB entries of the same protein (UniProt P0DP23 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9MXD 1.17 Å, Human E104A calmodulin:MLCK RM20 complex
7BF1 1.24 Å, Ca2+-Calmodulin in complex with peptide from brain-type creatine kinase in extended 1:2…
6XXX 1.25 Å, 1.25 Angstrom crystal structure of Ca/CaM A102V:RyR2 peptide complex
4DJC 1.35 Å, 1.35 A crystal structure of the NaV1.5 DIII-IV-Ca/CaM complex
7BF2 1.43 Å, Ca2+-Calmodulin in complex with human muscle form creatine kinase peptide in extended…
2F3Y 1.45 Å, Calmodulin/IQ domain complex
2W73 1.45 Å, High-resolution structure of the complex between calmodulin and a peptide from…
4LZX 1.5 Å, Complex of IQCG and Ca2+-free CaM
5V03 1.58 Å, A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole…
9MVW 1.58 Å, Crystal structure of S101F calmodulin - CaM:RM20 analog complex
2F3Z 1.6 Å, Calmodulin/IQ-AA domain complex
6M7H 1.6 Å, Structure of calmodulin with KN93

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