4Q5U: Calmodulin

Structure of calmodulin bound to its recognition site from calcineurin. Determined by X-ray diffraction at 1.95 Å resolution. Released 3 Sept 2014.

Method: X-ray diffraction
Resolution: 1.95 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,444
Mol. weight: 19.83 kDa
Ligands: CA
Released: 3 Sept 2014

Explore 4Q5U in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4Q5U contains 9 α-helices and 4 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	6-19	14
β-strand	26-27	2	1
α-helix	29-38	10
α-helix	45-55	11
β-strand	63-64	2	1
α-helix	65-72	8
α-helix	78-92	15
β-strand	99-100	2	2
α-helix	102-111	10
α-helix	118-128	11
β-strand	136-137	2	2
α-helix	138-145	8

Chain C: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	393-413	21

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Calmodulin	A	protein	149	Homo sapiens	P0DP23 (AlphaFold model)
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	C	protein	24	Homo sapiens	Q08209 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>4Q5U_1 Calmodulin (chains A)
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK

Sequence of entity 2 (C), FASTA

>4Q5U_2 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (chains C)
ARKEVIRNKIRAIGKMARVFSVLR

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	4

Primary citation

Stoichiometry of the calcineurin regulatory domain-calmodulin complex. Dunlap, T.B., Guo, H.F., Cook, E.C. et al. Biochemistry (2014) 53:5779-5790. DOI 10.1021/bi5004734 · PubMed

Other PDB entries of the same protein (UniProt P0DP23 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9MXD 1.17 Å, Human E104A calmodulin:MLCK RM20 complex
7BF1 1.24 Å, Ca2+-Calmodulin in complex with peptide from brain-type creatine kinase in extended 1:2…
6XXX 1.25 Å, 1.25 Angstrom crystal structure of Ca/CaM A102V:RyR2 peptide complex
4DJC 1.35 Å, 1.35 A crystal structure of the NaV1.5 DIII-IV-Ca/CaM complex
7BF2 1.43 Å, Ca2+-Calmodulin in complex with human muscle form creatine kinase peptide in extended…
2F3Y 1.45 Å, Calmodulin/IQ domain complex
2W73 1.45 Å, High-resolution structure of the complex between calmodulin and a peptide from…
4LZX 1.5 Å, Complex of IQCG and Ca2+-free CaM
5V03 1.58 Å, A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole…
9MVW 1.58 Å, Crystal structure of S101F calmodulin - CaM:RM20 analog complex
2F3Z 1.6 Å, Calmodulin/IQ-AA domain complex
6M7H 1.6 Å, Structure of calmodulin with KN93

Browse structure collections

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