4QXE: LGR4 fused with hagfish VLR

Crystal structure of LGR4 fused with hagfish VLR. Determined by X-ray diffraction at 2.2 Å resolution. Released 22 Oct 2014.

Method: X-ray diffraction
Resolution: 2.2 Å
Organisms: Homo sapiens, Eptatretus burgeri
Chains: 1
Atoms: 3,802
Mol. weight: 49.83 kDa
Ligands: NAG
Released: 22 Oct 2014

Explore 4QXE in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4QXE contains 7 α-helices and 33 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 33 β-strands

Element	Residues	Length	Sheet
β-strand	34-35	2	1
β-strand	40-42	3	1
α-helix	51-53	3
β-strand	61-63	3	1
β-strand	71-72	2	2
β-strand	85-87	3	1
β-strand	95-96	2	2
β-strand	109-111	3	1
β-strand	119	1	3
β-strand	133-135	3	1
β-strand	143	1	3
β-strand	157-159	3	1
α-helix	170-173	4
β-strand	181-183	3	1
β-strand	191-192	2	4
β-strand	205-207	3	1
β-strand	215-216	2	4
β-strand	229-231	3	1
α-helix	240-241	2
α-helix	242-246	5
β-strand	252-254	3	1
β-strand	262-263	2	5
β-strand	276-278	3	1
β-strand	286-287	2	5
β-strand	300-304	5	6
β-strand	323-327	5	6
β-strand	333	1	7
α-helix	338-341	4
β-strand	347-349	3	6
β-strand	357	1	7
β-strand	369-371	3	6
β-strand	393-395	3	6
β-strand	417-419	3	6
β-strand	425	1	8
α-helix	433-441	9
β-strand	446-447	2	6
β-strand	451	1	9
β-strand	452	1	8
β-strand	458	1	9
α-helix	459-461	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Leucine-rich repeat-containing G-protein coupled receptor 4, linker, Variable lymphocyte receptor B	A	protein	443	Homo sapiens, Eptatretus burgeri	Q4G1L2 (AlphaFold model), Q9BXB1 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>4QXE_1 Leucine-rich repeat-containing G-protein coupled receptor 4, linker, Variable lymphocyte receptor B (chains A)
MDPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEGAFKNFPFLE
ELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSV
PEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLV
VLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIP
DGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESL
TLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGT
FQGLISLRILDLASNQLKSVPDGIFDRLTSLQKIWLHTNPWDCSCPRIDYLSRWLNKNSQ
KEQGSAKCSGSGKPVRSIICPTL

Ligands and cofactors

ID	Name	Formula	Copies
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose	C8 H15 N O6	3

Water and common crystallization additives (SO4, CL, GOL) are not listed.

Primary citation

Crystal structure of LGR4 fused with hagfish VLR. Xu, J.G., Huang, C., Zhou, Y. et al. To be published.

Other PDB entries of the same protein (UniProt Q4G1L2 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2Z62 1.7 Å, Crystal structure of the TV3 hybrid of human TLR4 and hagfish VLRB.61
2Z66 1.9 Å, Crystal structure of the VT3 hybrid of human TLR4 and hagfish VLRB.61
2Z63 2.0 Å, Crystal structure of the TV8 hybrid of human TLR4 and hagfish VLRB.61
5GY2 2.1 Å, Crystal structure of a complex between Bacillus subtilis flagellin and zebrafish…
7MLM 2.1 Å, Crystal structure of mouse TLR4/MD-2 in complex with sulfatides
4QXF 2.25 Å, crystal structure of human LGR4 and Rspo1
6BXA 2.3 Å, Crystal structure of N-terminal fragment of Zebrafish Toll-Like Receptor 5 (TLR5) with…
2O6R 2.3 Å, Structural diversity of the hagfish Variable Lymphocyte Receptors B61
4BV4 2.35 Å, Structure and allostery in Toll-Spatzle recognition
3UL7 2.37 Å, Crystal structure of the TV3 mutant F63W
4QDH 2.4 Å, Crystal Structure of the C-terminal Domain of Mouse TLR9
3A7C 2.4 Å, Crystal structure of TLR2-PE-DTPA complex

Browse structure collections

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