4UI9: Anaphase-promoting complex subunit 1

Atomic structure of the human Anaphase-Promoting Complex. Determined by electron microscopy at 3.6 Å resolution. Released 17 Jun 2015.

Method
Electron microscopy
Resolution
3.6 Å
Organism
HOMO SAPIENS
Chains
23
Atoms
66,453
Mol. weight
1272.96 kDa
Ligands
ZN
Released
17 Jun 2015

Explore 4UI9 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4UI9 contains 427 α-helices and 155 β-strands across 22 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 69 helices, 52 β-strands

ElementResiduesLengthSheet
β-strand1311
β-strand17-1932
α-helix23-308
α-helix40-467
β-strand73-7863
β-strand90-9563
β-strand99-10353
β-strand115-11843
β-strand12314
β-strand127-13265
β-strand147-15485
β-strand15514
β-strand159-16355
β-strand168-17035
β-strand177-18046
β-strand18317
β-strand18617
β-strand187-19156
β-strand210-21346
α-helix219-2202
β-strand221-22226
β-strand22418
β-strand23818
β-strand245-25069
β-strand255-26069
β-strand265-26959
α-helix286-2949
β-strand411-41339
α-helix425-4273
β-strand430-434510
β-strand440-446710
β-strand451-459910
β-strand466-474910
β-strand478-482511
β-strand487-492611
β-strand496-500511
β-strand505-508411
β-strand51011
β-strand584-59182
β-strand594-59962
β-strand604-60852
α-helix609-6113
α-helix616-62813
α-helix632-64615
α-helix656-66611
α-helix759-77618
α-helix782-79716
α-helix801-8099
α-helix840-8423
α-helix844-85310
α-helix868-88114
α-helix925-93612
α-helix943-9453
α-helix949-96416
α-helix972-9776
α-helix981-9833
α-helix1021-10277
α-helix1033-10408
α-helix10461
β-strand1047112
α-helix10481
α-helix1059-108729
β-strand1092113
α-helix1093-10953
α-helix1102-11043
β-strand1108-1111412
β-strand1116-1119412
α-helix1133-114513
β-strand1147113
α-helix1155-11606
α-helix1169-118214
α-helix1184-11874
α-helix1190-119910
α-helix1202-121615
α-helix1222-123110
α-helix12371
α-helix1247-126014
α-helix1267-127711
α-helix1291-130616
α-helix1321-133010
α-helix1360-137415
α-helix1381-13866
α-helix1393-13986
α-helix1401-141414
α-helix1423-14297
α-helix1432-14365
α-helix1454-147522
α-helix1482-149918
α-helix1504-15074
α-helix1509-152618
α-helix1533-154513
α-helix1552-156514
β-strand1572-1574314
α-helix1579-15879
α-helix1604-16096
α-helix1610-16134
β-strand1614-1616314
β-strand1620-1622315
β-strand1629115
β-strand1633-1639716
β-strand1646-1652716
α-helix1656-16572
α-helix16591
β-strand1663-1668616
β-strand1673117
β-strand1675-1678416
α-helix1685-16928
β-strand1696-1698315
α-helix17001
β-strand1701117
α-helix17021
α-helix1748-17536
α-helix1754-17585
α-helix1768-178316
α-helix1789-180517
α-helix1812-182413
α-helix1848-186518
α-helix1868-18758
α-helix1882-189514
α-helix1912-19209
α-helix1926-19349
Chain B: 1 helix, 10 β-strands
ElementResiduesLengthSheet
β-strand3-9718
β-strand13119
β-strand22120
β-strand29120
β-strand46-48321
β-strand49122
β-strand54-56321
α-helix57-6711
β-strand72123
β-strand79123
β-strand82122
Chain C: 32 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix29-4618
α-helix49-6113
α-helix63-653
α-helix72-765
α-helix78-9619
α-helix99-1068
α-helix112-13625
α-helix151-16414
α-helix170-18112
α-helix185-19814
α-helix203-21210
α-helix216-2216
α-helix229-24113
α-helix244-25411
α-helix255-2595
α-helix263-27614
α-helix279-29214
α-helix300-30910
α-helix313-32614
α-helix331-34414
α-helix347-36014
α-helix366-37712
α-helix381-39414
α-helix399-41113
α-helix415-42814
α-helix433-44614
α-helix449-46214
α-helix469-47911
α-helix484-49916
α-helix510-52213
α-helix526-53914
α-helix544-55613
Chain D: 3 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix9-113
α-helix26-4520
α-helix52-532
Chain E: 3 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix53-9139
α-helix97-982
α-helix99-1024
Chain F: 31 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix7-1711
α-helix21-3515
α-helix38-5013
α-helix54-6310
α-helix69-8113
α-helix85-939
α-helix104-1107
α-helix111-1133
α-helix114-12815
α-helix131-14414
α-helix149-1579
α-helix162-1632
α-helix452-47827
α-helix481-4899
α-helix499-51113
α-helix515-52814
α-helix536-54611
α-helix549-56214
α-helix567-57913
α-helix583-59614
α-helix601-61414
α-helix617-63014
α-helix635-64713
α-helix651-66414
α-helix669-68214
α-helix685-69814
α-helix703-71513
α-helix719-73214
α-helix737-75014
α-helix753-76614
α-helix770-81812
Chain G: 2 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix4-74
α-helix13-2412
Chain H: 30 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix7-1711
α-helix21-3515
α-helix38-5013
α-helix54-6310
α-helix69-8113
α-helix85-939
α-helix104-1107
α-helix111-1133
α-helix114-12815
α-helix131-14414
α-helix149-1579
α-helix164-1685
α-helix452-47827
α-helix481-4899
α-helix499-51113
α-helix515-52814
α-helix536-54611
α-helix549-56214
α-helix567-57913
α-helix583-59614
α-helix601-61414
α-helix617-63014
α-helix635-64713
α-helix651-66414
α-helix669-68214
α-helix685-69814
α-helix703-71513
α-helix719-73214
α-helix737-75014
α-helix753-76614

14 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Anaphase-promoting complex subunit 1Aprotein1944HOMO SAPIENSQ9H1A4 (AlphaFold model)
Anaphase-promoting complex subunit 11Bprotein84HOMO SAPIENSQ9NYG5 (AlphaFold model)
Cell division cycle protein 23 homologC, Pprotein591HOMO SAPIENSQ9UJX2 (AlphaFold model)
Anaphase-promoting complex subunit 15Dprotein121HOMO SAPIENSP60006 (AlphaFold model)
Anaphase-promoting complex subunit 16Eprotein110HOMO SAPIENSQ96DE5
Cell division cycle protein 27 homologF, Hprotein824HOMO SAPIENSP30260
Anaphase-promoting complex subunit CDC26Gprotein85HOMO SAPIENSQ8NHZ8
Anaphase-promoting complex subunit 4Iprotein808HOMO SAPIENSQ9UJX5
Cell division cycle protein 16 homologJprotein620HOMO SAPIENSQ13042
Cell division cycle protein 16 homologKprotein620HOMO SAPIENSQ13042
Anaphase-promoting complex subunit 10Lprotein183HOMO SAPIENSQ9UM13
Anaphase-promoting complex subunit 13Mprotein74HOMO SAPIENSQ9BS18

8 more molecules are not listed.

Sequence of entity 1 (A), FASTA
>4UI9_1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 1 (chains A)
MSNFYEERTTMIAARDLQEFVPFGRDHCKHHPNALNLQLRQLQPASELWSSDGAAGLVGS
LQEVTIHEKQKESWQLRKGVSEIGEDVDYDEELYVAGNMVIWSKGSKSQALAVYKAFTVD
SPVQQALWCDFIISQDKSEKAYSSNEVEKCICILQSSCINMHSIEGKDYIASLPFQVANV
WPTKYGLLFERSASSHEVPPGSPREPLPTMFSMLHPLDEITPLVCKSGSLFGSSRVQYVV
DHAMKIVFLNTDPSIVMTYDAVQNVHSVWTLRRVKSEEENVVLKFSEQGGFPQNVATSSS
LTAHLRSLSKGDSPVTSPFQNYSSIHSQSRSTSSPSLHSRSPSISNMAALSRAHSPALGV
HSFSGVQRFNISSHNQSPKRHSISHSPNSNSNGSFLAPETEPIVPELCIDHLWTETITNI
REKNSQASKVFITSDLCGQKFLCFLVESQLQLRCVKFQESNDKTQLIFGSVTNIPAKDAA
PVEKIDTMLVLEGSGNLVLYTGVVRVGKVFIPGLPAPSLTMSNTMPRPSTPLDGVSTPKP
LSKLLGSLDEVVLLSPVPELRDSSKLHDSLYNEDCTFQQLGTYIHSIRDPVHNRVTLELS
NGSMVRITIPEIATSELVQTCLQAIKFILPKEIAVQMLVKWYNVHSAPGGPSYHSEWNLF
VTCLMNMMGYNTDRLAWTRNFDFEGSLSPVIAPKKARPSETGSDDDWEYLLNSDYHQNVE
SHLLNRSLCLSPSEASQMKDEDFSQNLSLDSSTLLFTHIPAIFFVLHLVYEELKLNTLMG
EGICSLVELLVQLARDLKLGPYVDHYYRDYPTLVRTTGQVCTIDPGQTGFMHHPSFFTSE
PPSIYQWVSSCLKGEGMPPYPYLPGICERSRLVVLSIALYILGDESLVSDESSQYLTRIT
IAPQKLQVEQEENRFSFRHSTSVSSLAERLVVWMTNVGFILRDLETLPFGIALPIRDAIY
HCREQPASDWPEAVCLLIGRQDLSKQACEGNLPKGKSVLSSDVPSGTETEEEDDGMNDMN
HEVMSLIWSEDLRVQDVRRLLQSAHPVRVNVVQYPELSEHEFIEEKENRLLQLCQRTMAL
PVGRGMFTLFSYHPVPTEPLPIPKLNLTGRAPPRNTTVDLNSGNIDVPPNMTSWASFHNG
VAAGLKIAPASQIDSAWIVYNKPKHAELANEYAGFLMALGLNGHLTKLATLNIHDYLTKG
HEMTSIGLLLGVSAAKLGTMDMSITRLLSIHIPALLPPTSTELDVPHNVQVAAVVGIGLV
YQGTAHRHTAEVLLAEIGRPPGPEMEYCTDRESYSLAAGLALGMVCLGHGSNLIGMSDLN
VPEQLYQYMVGGHRRFQTGMHREKHKSPSYQIKEGDTLNVDVTCPGATLALAMIYLKTNN
RSIADWLRAPDTMYLLDFVKPEFLLLRTLARCLILWDDILPNSKWVDSNVPQIIRENSIS
LSEIELPCSEDLNLETLSQAHVYIIAGACLSLGFRFAGSENLSAFNCLHKFAKDFMTYLS
APNASVTGPHNLETCLSVVLLSLAMVMAGSGNLKVLQLCRFLHMKTGGEMNYGFHLAHHM
ALGLLFLGGGRYSLSTSNSSIAALLCALYPHFPAHSTDNRYHLQALRHLYVLAAEPRLLV
PVDVDTNTPCYALLEVLYKGTQWYEQTKEELMAPTLLPELHLLKQIKVKGPRYWELLIDL
SKGTQHLKSILSKDGVLYVKLRAGQLSYKEDPMGWQSLLAQTVANRNSEARAFKPETISA
FTSDPALLSFAEYFCKPTVNMGQKQEILDLFSSVLYECVTQETPEMLPAYIAMDQAIRRL
GRREMSETSELWQIKLVLEFFSSRSHQERLQNHPKRGLFMNSEFLPVVKCTIDNTLDQWL
QVGGDMCVHAYLSGQPPLESQLSMLACFLVYHSVPAPQHLPPIGLEGSTSFAELLFKFKQ
LKMPVRALLRLAPLLLGNPQPMVM
Sequence of entity 2 (B), FASTA
>4UI9_2 ANAPHASE-PROMOTING COMPLEX SUBUNIT 11 (chains B)
MKVKIKCWNGVALWLWVANDENCGICRMAFNGCCPDCKVPGDDCPLVWGQCSHCFHMHCI
LKWLHAQQVQQHCPMCRQEWKFKE
Sequence of entity 3 (C, P), FASTA
>4UI9_3 CELL DIVISION CYCLE PROTEIN 23 HOMOLOG (chains C, P)
MVPVAVTAAVAPVLSINSDFSDLREIKKQLLLIAGLTRERGLLHSSKWSAELAFSLPALP
LAELQPPPPITEEDAQDMDAYTLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMYSRYLSG
EKKKDDETVDSLGPLEKGQVKNEALRELRVELSKLHQARELDGFGLYLYGVVLRKLDLVK
EAIDVFVEATHVLPLHWGAWLELCNLITDKEMLKFLSLPDTWMKEFFLAHIYTELQLIEE
ALQKYQNLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRIENMDTFSNL
LYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLG
AWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAH
QLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQA
AQCYIKYIQDIYSCGEIVEHLEESTAFRYLAQYYFKCKLWDEASTCAQKCCAFNDTREEG
KALLRQILQLRNQGETPTTEVPAPFFLPASLSANNTPTRRVSPLNLSSVTP
Sequence of entity 4 (D), FASTA
>4UI9_4 ANAPHASE-PROMOTING COMPLEX SUBUNIT 15 (chains D)
MSTLYPSLFPRVTETLWFNLDRPCVEETELQQQEQQHQAWLQSIAEKDNNLVPIGKPASE
HYDDEEEEDDEDDEDSEEDSEDDEDMQDMDEMNDYNESPDDGEVNEVDMEGNEQDQDQWM
I
Sequence of entity 5 (E), FASTA
>4UI9_5 ANAPHASE-PROMOTING COMPLEX SUBUNIT 16 (chains E)
MAASSSSSSAGGVSGSSVTGSGFSVSDLAPPRKALFTYPKGAGEMLEDGSERFLCESVFS
YQVASTLKQVKHDQQVARMEKLAGLVEELEADEWRFKPIEQLLGFTPSSG
Sequence of entity 6 (F, H), FASTA
>4UI9_6 CELL DIVISION CYCLE PROTEIN 27 HOMOLOG (chains F, H)
MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRL
LKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDIVTEFGDSACFTLSL
LGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKFTSLQNFSNCL
PNSCTTQVPNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSAVI
SPDTVPLGTGTSILSKQVQNKPKTGRSLLGGPAALSPLTPSFGILPLETPSPGDGSYLQN
YTNTPPVIDVPSTGAPSKKSVARIGQTGTKSVFSQSGNSREVTPILAQTQSSGPQTSTTP
QVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPEIPNRKTKSKTNKGGITQ
PNINDSLEITKLDSSIISEGKISTITPQIQAFNLQKAAAEGLMSLLREMGKGYLSLCSYN
CKESINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYS
TTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNY
AYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQK
ALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYK
SALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAID
KRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF
Sequence of entity 7 (G), FASTA
>4UI9_7 ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26 (chains G)
MLRRKPTRLELKLEDIEEFENIRKDLETRKKQKEDVEVVGGSDGEGAIGLSSDPKSREQM
INDRIGYKPQPKPNNRSSQFGSLEF
Sequence of entity 8 (I), FASTA
>4UI9_8 ANAPHASE-PROMOTING COMPLEX SUBUNIT 4 (chains I)
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPP
NENTGKEVTCLAWRPDGKLLAFALADTKKIVLCDVEKPESLHSFSVEAPVSCMHWMEVTV
ESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNL
LYSFLPEVTRMARKFTHISALLQYINLSLTCMCEAWEEILMQMDSRLTKFVQEKNTTTSV
QDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQVIDSSMKNFKAFFRW
LYVAMLRMTDDHVLPELNKMTQKDITFVAEFLTEHFNEAPDLYNRKGKYFNVERVGQYLK
DEDDDLVSPPNTEGNQWYDFLQNSSHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQKP
ADVIGKSMNQAICIPLYRDTRSEDSTRRLFKFPFLWNNKTSNLHYLLFTILEDSLYKMCI
LRRHTDISQSVSNGLIAIKFGSFTYATTEKVRRSIYSCLDAQFYDDETVTVVLKDTVGRE
GRDRLLVQLPLSLVYNSEDSAEYQFTGTYSTRLDEQCSAIPTRTMHFEKHWRLLESMKAQ
YVAGNGFRKVSCVLSSNLRHVRVFEMDIDDEWELDESSDEEEEASNKPVKIKEEVLSESE
AENQQAGAAALAPEIVIKVEKLDPELDS
Sequence of entity 9 (J), FASTA
>4UI9_9 CELL DIVISION CYCLE PROTEIN 16 HOMOLOG (chains J)
MNLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHAL
RSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDMEEPINKRLFEKYLKDESGFKDPSSD
WEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQE
EKELLESLPLSKLCNEEQELLRFLFENKLKKYNKPSETVIPESVNGLEKNLDVVVSLAER
HYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPV
SWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTA
AQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKT
AEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNAS
TYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKD
KLKCYDFDVHTMKTLKNIISPPWDFREFEVEKQTAEETGLTPLETSRKTPDSRPSLEETF
EIEMNESDMMLETSMSDHST
Sequence of entity 10 (K), FASTA
>4UI9_10 CELL DIVISION CYCLE PROTEIN 16 HOMOLOG (chains K)
MNLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHAL
RSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDMEEPINKRLFEKYLKDESGFKDPSSD
WEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQE
EKELLESLPLSKLCNEEQELLRFLFENKLKKYNKPSETVIPESVDGLEKNLDVVVSLAER
HYYNCDFKMCYKLTSVVMEKDPFHKSCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPV
SWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTA
AQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKT
AEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNAS
TYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKD
KLKCYDFDVHTMKTLKNIISPPWDFREFEVEKQTAEETGLTPLETSRKTPDSRPSLEETF
EIEMNESDMMLETSMSDHST
Sequence of entity 11 (L), FASTA
>4UI9_11 ANAPHASE-PROMOTING COMPLEX SUBUNIT 10 (chains L)
TTPNKTPPGADPKQLERTGTVREIGSQAVWSLSSCKPGFGVDQLRDDNLETYWQSDGSQP
HLVNIQFRRKTTVKTLCIYADYKSDESYTPSKISVRVGNNFHNLQEIRQLELVEPSGWIH
VPLTDNHKKPTRTFMIQIAVLANHQNGRDTHMRQIKIYTPVESSIGKFPRCTTIDFMMYR
SIR
Sequence of entity 12 (M), FASTA
>4UI9_12 ANAPHASE-PROMOTING COMPLEX SUBUNIT 13 (chains M)
MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLNELPEPEQDNGGTTESVKEQEMKWTDL
ALQYLHENVPPIGN

Ligands and cofactors

IDNameFormulaCopies
ZNZinc ionZn5

Primary citation

Atomic Structure of the Apc and its Mechanism of Protein Ubiquitination. Chang, L., Zhang, Z., Yang, J. et al. Nature (2015) 522:450. DOI 10.1038/NATURE14471 · PubMed

Other PDB entries of the same protein (UniProt Q9H1A4 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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