Crystal Structure of RPA70N in complex with VU0085636. Determined by X-ray diffraction at 1.21 Å resolution. Released 27 Jan 2016.
Explore 5E7N in 3D Show helices and sheets RCSB PDB PDBe
5E7N contains 8 α-helices and 6 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 1-4 | 4 | |
| α-helix | 9-11 | 3 | |
| α-helix | 12-16 | 5 | |
| β-strand | 24-33 | 10 | 1 |
| α-helix | 34 | 1 | |
| α-helix | 39-40 | 2 | |
| β-strand | 41-47 | 7 | 1 |
| β-strand | 51-58 | 8 | 1 |
| α-helix | 60-62 | 3 | |
| α-helix | 63-67 | 5 | |
| β-strand | 76-86 | 11 | 1 |
| β-strand | 92-103 | 12 | 1 |
| α-helix | 105-108 | 4 | |
| β-strand | 116-117 | 2 | 1 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Replication protein A 70 kDa DNA-binding subunit | A | protein | 123 | Homo sapiens | P27694 (AlphaFold model) |
>5E7N_1 Replication protein A 70 kDa DNA-binding subunit (chains A) GSHMVGQLSRGAIAAIMQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFM LATQLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLKSAEAVGVKIGNPVP YNE
| ID | Name | Formula | Copies |
|---|---|---|---|
| 5KR | 2-({3-[(4-bromophenyl)sulfamoyl]-4-methylbenzoyl}amino)benzoic acid | C21 H17 Br N2 O5 S | 1 |
Identification and Optimization of Anthranilic Acid Based Inhibitors of Replication Protein A. Patrone, J.D., Pelz, N.F., Bates, B.S. et al. ChemMedChem (2016) 11:893-899. DOI 10.1002/cmdc.201500479 · PubMed
Other PDB entries of the same protein (UniProt P27694 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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