5L0F: Human metavinculin quadruple mutant

Human metavinculin quadruple mutant (residues 959-1134). Determined by X-ray diffraction at 2.76 Å resolution. Released 31 Aug 2016.

Method: X-ray diffraction
Resolution: 2.76 Å
Organism: Homo sapiens
Chains: 2
Atoms: 3,038
Mol. weight: 39.25 kDa
Released: 31 Aug 2016

Explore 5L0F in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5L0F contains 13 α-helices and 4 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 6 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	964-977	14
β-strand	980	1	1
α-helix	986-1004	19
α-helix	1009-1011	3
α-helix	1012-1039	28
α-helix	1043-1073	31
α-helix	1081-1113	33
β-strand	1128	1	1

Chain B: 7 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	964-977	14
β-strand	980	1	2
α-helix	986-1004	19
α-helix	1009-1011	3
α-helix	1012-1039	28
α-helix	1043-1073	31
α-helix	1081-1112	32
α-helix	1113-1115	3
β-strand	1128	1	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Vinculin	A, B	protein	176	Homo sapiens	P18206 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>5L0F_1 Vinculin (chains A, B)
NQPVNQPILAAAQSLHQEATQWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQC
AKDIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTN
ISDEESEQATEMLVHNAQNLMQSVKETVQEAEAASIKIRTDAGFTLRWVQKTPWYQ

Primary citation

Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization. Chinthalapudi, K., Rangarajan, E.S., Brown, D.T. et al. Proc Natl Acad Sci U S A (2016) 113:9539-9544. DOI 10.1073/pnas.1600702113 · PubMed

Other PDB entries of the same protein (UniProt P18206 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4LN2 1.0 Å, The second SH3 domain from CAP/Ponsin in complex with proline rich peptide from Vinculin
4LNP 1.41 Å, The first SH3 domain from CAP/Ponsin in complex with proline rich peptide from Vinculin
3RF3 1.61 Å, Shigella IpaA-VBS3 in complex with human vinculin
1YDI 1.8 Å, Human Vinculin Head Domain (VH1, 1-258) in Complex with Human Alpha-Actinin's…
3S90 1.97 Å, Human vinculin head domain Vh1 (residues 1-252) in complex with murine talin (VBS33;…
3TJ5 1.99 Å, human vinculin head domain (Vh1, residues 1-258) in complex with the vinculin binding…
3MYI 2.2 Å, Human metavinculin tail domain
4DJ9 2.25 Å, Human vinculin head domain Vh1 (residues 1-258) in complex with the talin vinculin…
1RKE 2.35 Å, Human vinculin head (1-258) in complex with human vinculin tail (879-1066)
1SYQ 2.42 Å, Human vinculin head domain VH1, residues 1-258, in complex with human talin's vinculin…
5L0I 2.45 Å, Human metavinculin MVt R975W cardiomyopathy-associated mutant (residues 959-1134)
3VF0 2.54 Å, Raver1 in complex with metavinculin L954 deletion mutant

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