5T5W: Interleukin-10 receptor subunit beta

Structure of an affinity matured lambda-IFN/IFN-lambdaR1/IL-10Rbeta receptor complex. Determined by X-ray diffraction at 2.85 Å resolution. Released 29 Mar 2017.

Method
X-ray diffraction
Resolution
2.85 Å
Organism
Homo sapiens
Chains
3
Atoms
4,266
Mol. weight
70.32 kDa
Ligands
NAG
Released
29 Mar 2017

Explore 5T5W in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5T5W contains 26 α-helices and 37 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 17 β-strands

ElementResiduesLengthSheet
α-helix22-243
β-strand25-3281
β-strand35-4171
α-helix42-443
β-strand51-5772
β-strand62-6982
β-strand73-7531
β-strand85-9392
β-strand96-9722
β-strand101-10552
α-helix107-1104
β-strand11211
α-helix115-1162
β-strand117-12373
β-strand126-13273
α-helix133-1353
α-helix145-1484
β-strand153-16084
β-strand167-16934
β-strand175-17733
α-helix181-1822
β-strand186-195104
β-strand200-20124
α-helix203-2075
β-strand208-21144
Chain B: 6 helices, 20 β-strands
ElementResiduesLengthSheet
β-strand9-1575
β-strand18-2475
β-strand35-4176
β-strand49-5026
β-strand5716
β-strand61-6335
β-strand75-8286
β-strand8317
β-strand8817
α-helix89-913
β-strand92-9326
β-strand97-9826
α-helix99-1024
α-helix103-1053
β-strand109-11578
β-strand118-12478
β-strand136-14499
β-strand151-15229
α-helix153-1553
β-strand156-15729
α-helix1611
β-strand162-16548
β-strand173-183119
β-strand187-18939
α-helix191-1955
β-strand196-19949
Chain C: 12 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix7-104
α-helix14-3118
α-helix451
α-helix49-513
α-helix57-7822
α-helix83-10119
α-helix117-12610
α-helix134-14310
α-helix145-1462
α-helix147-1526
α-helix153-1575
α-helix159-1613

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Interleukin-10 receptor subunit betaAprotein214Homo sapiensQ08334 (AlphaFold model)
Interferon lambda receptor 1Bprotein218Homo sapiensQ8IU57 (AlphaFold model)
Interferon lambda-3Cprotein176Homo sapiensQ8IZI9 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>5T5W_1 Interleukin-10 receptor subunit beta (chains A)
GSMVPPPENVRMNSVNFKNILQWESPAFAKGQLTFTAQYLSYRIFQDKCMQTTLTECDFS
SLSKYGDHTLRVRAEFADEHSDWVQITFCPVDDTIIGPPGMQVEVLADSLHMRFLAPKIE
NEYETWTMKNVYNSWTYNVQYWKQGTDEKFQITPQYDFEVLRNLEPWTTYCVQVRGFLPD
RNKAGEWSEPVCEQTTHDETVPSAAAHHHHHHHH
Sequence of entity 2 (B), FASTA
>5T5W_2 Interferon lambda receptor 1 (chains B)
TSRRPRLAPPQNVTLLSQNFSVYLTWLPGLGNPQDVTYFVAYQSSPTRRRWREVEECAGT
KELLCSMMCLKKQDLYNKFKGRVRTVSPSSKSPWVESEYLDYLFEVEPAPPVLVLTQTEE
ILSANATYQLPPCMPPLDLKYEVAFWKEGAGNKTLFPVTPHGQPVQITLQPAASEHHCLS
ARTIYTFSVPKYSKFSKPTCFLLEVPEANAAALEVLFQ
Sequence of entity 3 (C), FASTA
>5T5W_3 Interferon lambda-3 (chains C)
GSARGCHIAQFKSLSPRELQAFKRAKDALEESLLLKDCKCRSRLFPRTWDLRQLQVRERP
VALEAELALTLKVLDATADTDPALGDVLDQPLHTLHHILSQLRACIQPQPTAGPRTRGRL
HRWLHRLQEAPKKESPGCLEASVTFNLFRLLARDLNCVASGDLCEAAAHHHHHHHH

Ligands and cofactors

IDNameFormulaCopies
NAG2-acetamido-2-deoxy-beta-D-glucopyranoseC8 H15 N O63

Primary citation

The IFN-lambda-IFN-lambda R1-IL-10R beta Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity. Mendoza, J.L., Schneider, W.M., Hoffmann, H.H. et al. Immunity (2017) 46:379-392. DOI 10.1016/j.immuni.2017.02.017 · PubMed

Other PDB entries of the same protein (UniProt Q08334 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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