9BPV: Interleukin-10 receptor subunit beta

Structure of the IFN-lambda3/IFN-lambdaR1/IL-10Rbeta receptor complex with an engineered IL-10Rbeta. Determined by electron microscopy at 3.0 Å resolution. Released 29 Jan 2025.

Method
Electron microscopy
Resolution
3.0 Å
Organism
Homo sapiens
Chains
3
Atoms
4,417
Mol. weight
68.72 kDa
Ligands
NAG
Released
29 Jan 2025

Explore 9BPV in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9BPV contains 26 α-helices and 38 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 17 β-strands

ElementResiduesLengthSheet
α-helix21-244
β-strand25-3281
β-strand35-4171
α-helix42-443
β-strand51-5882
β-strand61-6992
β-strand73-7531
β-strand85-9392
β-strand96-9722
β-strand101-10552
α-helix107-1104
β-strand11211
α-helix113-1164
β-strand117-12373
β-strand126-13273
α-helix133-1353
α-helix145-1484
β-strand153-16084
β-strand167-16934
β-strand175-17843
α-helix181-1822
β-strand185-195114
β-strand200-20124
α-helix202-2076
β-strand208-21254
Chain B: 8 helices, 21 β-strands
ElementResiduesLengthSheet
β-strand11-1555
β-strand18-2255
β-strand35-4176
α-helix491
β-strand5016
α-helix511
β-strand5716
β-strand61-6335
β-strand76-8276
β-strand8317
β-strand8817
α-helix89-913
β-strand92-9326
β-strand9716
α-helix99-1024
α-helix105-1084
β-strand109-11578
β-strand118-12478
β-strand136-14499
β-strand150-15239
α-helix153-1553
β-strand156-15729
α-helix1611
β-strand162-16548
β-strand173110
β-strand174-183109
β-strand187-18939
α-helix191-1944
β-strand199110
Chain C: 10 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix6-105
α-helix14-3320
α-helix49-513
α-helix56-7823
α-helix80-10122
α-helix117-12711
α-helix134-14310
α-helix145-1462
α-helix147-1526
α-helix153-1586

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Interleukin-10 receptor subunit betaAprotein212Homo sapiensQ08334 (AlphaFold model)
Interferon lambda receptor 1Bprotein209Homo sapiensQ8IU57 (AlphaFold model)
Interferon lambda-3Cprotein176Homo sapiensQ8IZI9 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>9BPV_1 Interleukin-10 receptor subunit beta (chains A)
GSMVPPPENVRMNSVNFKNILQWESPAFAKGQLTFTAQYLSYRIFQDKCMQTTLTECDFS
SLSKYGDHTLRVRAEFADEHSDWVQITFCPVDDTIIGPPGMQVEVLADSLHMRFLAPKIE
NEYETWTMKDMYNSWTYNVQYWKQGTDEKFQITPQYDFEVLRNLEPRTTYCVQVRGFLPD
RNKAGEWSEPVCEQTTHDETVPSAAAHHHHHH
Sequence of entity 2 (B), FASTA
>9BPV_2 Interferon lambda receptor 1 (chains B)
RPRLAPPQNVTLLSQNFSVYLTWLPGLGNPQDVTYFVAYQSSPTRRRWREVEECAGTKEL
LCSMMCLKKQDLYNKFKGRVRTVSPSSKSPWVESEYLDYLFEVEPAPPVLVLTQTEEILS
ANATYQLPPCMPPLDLKYEVAFWKEGAGNKTLFPVTPHGQPVQITLQPAASEHHCLSART
IYTFSVPKYSKFSKPTCFLLEVPEANAAA
Sequence of entity 3 (C), FASTA
>9BPV_3 Interferon lambda-3 (chains C)
GSARGCHIAQFKSLSPQELQAFKRAKDALEESLLLKDCKCRSRLFPRTWDLRQLQVRERP
VALEAELALTLKVLEATADTDPALGDVLDQPLHTLHHILSQLRACIQPQPTAGPRTRGRL
HHWLHRLQEAPKKESPGCLEASVTFNLFRLLTRDLNCVASGDLCVAAAHHHHHHHH

Ligands and cofactors

IDNameFormulaCopies
NAG2-acetamido-2-deoxy-beta-D-glucopyranoseC8 H15 N O62

Primary citation

Structural studies of the IFN lambda 4 receptor complex using cryoEM enabled by protein engineering. Grubbe, W.S., Zhang, B., Kauffman, A. et al. Nat Commun (2025) 16:818-818. DOI 10.1038/s41467-025-56119-y · PubMed

Other PDB entries of the same protein (UniProt Q08334 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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