5YZ0: Human ATR-ATRIP complex

Cryo-EM Structure of human ATR-ATRIP complex. Determined by electron microscopy at 4.7 Å resolution. Released 31 Jan 2018.

Method
Electron microscopy
Resolution
4.7 Å
Organism
Homo sapiens
Chains
4
Atoms
33,371
Mol. weight
775.39 kDa
Released
31 Jan 2018

Explore 5YZ0 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5YZ0 contains 302 α-helices and 26 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 135 helices, 13 β-strands

ElementResiduesLengthSheet
α-helix3-75
α-helix11-177
α-helix27-4317
α-helix51-7020
α-helix78-9013
α-helix91-933
α-helix97-11923
α-helix124-14118
α-helix146-1494
α-helix150-1523
α-helix156-16510
α-helix171-18717
α-helix194-20815
α-helix213-22917
α-helix240-24910
α-helix254-2585
α-helix263-27917
α-helix285-30218
α-helix313-32513
α-helix338-35518
α-helix362-38120
α-helix388-3925
α-helix394-3963
α-helix398-41316
α-helix422-44120
α-helix448-45811
α-helix470-4745
α-helix484-49916
α-helix502-51514
α-helix521-53616
α-helix541-55818
α-helix563-57513
α-helix582-59514
α-helix599-61214
α-helix622-63413
α-helix635-6373
α-helix642-65211
α-helix659-6624
α-helix665-67713
α-helix682-69413
α-helix695-6973
α-helix703-71513
α-helix717-7204
α-helix724-73815
α-helix745-7495
α-helix750-76112
α-helix777-78812
α-helix798-80710
α-helix814-82512
α-helix832-8387
α-helix842-8476
α-helix853-86513
α-helix874-88411
α-helix890-90314
α-helix911-92818
α-helix935-94511
α-helix955-96814
α-helix974-99017
α-helix998-101114
α-helix1015-102915
α-helix1037-104812
α-helix1053-106715
α-helix1104-111714
α-helix1123-113614
α-helix1141-11444
α-helix1153-116210
α-helix1171-118111
α-helix1384-139714
α-helix1401-141313
α-helix1421-143313
α-helix1439-14435
α-helix1447-14548
α-helix1475-14817
α-helix1487-149812
α-helix1504-151916
α-helix1522-153817
α-helix1543-155816
α-helix1573-160230
α-helix1616-163520
α-helix1639-16479
α-helix1652-166312
α-helix1669-168113
α-helix1686-16938
α-helix1702-171211
α-helix1718-17269
α-helix1734-174512
α-helix1749-176214
α-helix1768-17703
α-helix1785-17906
α-helix1800-181213
α-helix1816-183419
α-helix1843-18453
α-helix1848-186821
α-helix1893-18964
α-helix1905-19128
α-helix1913-19153
α-helix1923-193614
α-helix1946-19505
α-helix1959-197214
α-helix1976-19827
α-helix1986-19883
α-helix1998-20014
α-helix2006-20094
α-helix2013-20164
α-helix2022-203110
α-helix2033-20364
α-helix2044-205613
α-helix2064-207714
α-helix2087-210822
α-helix2112-213221
α-helix2135-21384
α-helix2142-21476
α-helix2156-216914
α-helix2174-218310
α-helix2188-220215
α-helix2206-22083
α-helix2209-222719
β-strand2243-224421
α-helix2245-22484
α-helix2250-22534
β-strand226112
β-strand229212
β-strand2299-230021
β-strand2301-230223
β-strand2310-231343
β-strand2323-232643
α-helix2333-235119
α-helix2354-23585
β-strand2367-236933
β-strand2375-237843
β-strand238314
α-helix2386-239611
α-helix2417-242812
α-helix2435-24428
α-helix2449-247022
β-strand2481-248335
β-strand248414
β-strand2490-249235
α-helix2501-25044
α-helix2517-25226
α-helix2531-254515
α-helix2548-25514
α-helix2553-25586
α-helix2588-25969
α-helix2613-26153
α-helix2616-262510
α-helix2630-26334
α-helix2638-26403
Chain B: 131 helices, 11 β-strands
ElementResiduesLengthSheet
α-helix3-1614
α-helix27-4317
α-helix51-7020
α-helix78-9114
α-helix97-11923
α-helix124-14320
α-helix147-1526
α-helix156-1649
α-helix171-18717
α-helix194-20815
α-helix213-2186
α-helix220-2289
α-helix236-24914
α-helix254-2574
α-helix263-27816
α-helix285-30218
α-helix313-32715
α-helix338-35417
α-helix363-38220
α-helix394-3963
α-helix398-41518
α-helix423-44119
α-helix447-45812
α-helix471-4777
α-helix478-4803
α-helix484-49916
α-helix502-51514
α-helix522-53514
α-helix543-55715
α-helix563-57311
α-helix581-59515
α-helix599-61214
α-helix624-63411
α-helix642-65211
α-helix659-67719
α-helix682-69514
α-helix701-71919
α-helix724-73815
α-helix750-76314
α-helix776-78712
α-helix793-7964
α-helix798-80710
α-helix815-82511
α-helix832-8387
α-helix842-8454
α-helix850-86516
α-helix874-88411
α-helix890-90011
α-helix911-93020
α-helix935-94814
α-helix957-96711
α-helix974-99017
α-helix1000-101011
α-helix1015-103016
α-helix1040-10423
α-helix1053-106513
α-helix1104-111411
α-helix1123-113513
α-helix1153-116210
α-helix1169-11746
α-helix1176-11794
α-helix1385-139713
α-helix1402-141312
α-helix1414-14163
α-helix1421-143212
α-helix1439-14424
α-helix1447-14548
α-helix1472-14787
α-helix1487-149812
α-helix1504-151916
α-helix1522-15265
α-helix1529-15368
α-helix1542-15443
α-helix1545-155713
α-helix1573-160028
α-helix1616-163318
α-helix1639-16479
α-helix1653-166311
α-helix1675-16828
α-helix1686-16938
α-helix1702-17076
α-helix1709-17124
α-helix1718-172811
α-helix1734-174512
α-helix1749-176012
α-helix1770-17745
α-helix1777-17793
α-helix1785-17906
α-helix1802-181211
α-helix1816-182611
α-helix1843-18464
α-helix1848-186417
α-helix1865-18673
α-helix1893-18964
α-helix1905-19128
α-helix1914-19174
α-helix1923-193816
α-helix1944-19463
α-helix1947-19504
α-helix1959-197214
α-helix1976-19827
α-helix19911
α-helix1998-20047
α-helix2012-20154
α-helix2022-203110
α-helix2043-205614
α-helix2065-207713
α-helix2087-209913
α-helix2102-21087
α-helix2112-213221
α-helix2135-21384
α-helix2142-21476
α-helix2154-216815
α-helix2172-218312
α-helix2188-220215
α-helix2209-222719
β-strand2243-224426
α-helix2245-22484
α-helix2250-22534
β-strand226117
β-strand229217
β-strand2299-230026
β-strand2301-230228
β-strand2310-231348
β-strand2323-232648
α-helix2333-235119
α-helix2353-23575
α-helix2362-23643
β-strand2367-236938
β-strand2375-237958
α-helix2386-23949
α-helix2417-24259
α-helix2435-24428
α-helix2451-247121
β-strand2481-248339
β-strand2490-249239
α-helix2517-25215
α-helix2531-254515
α-helix2547-255812
α-helix2588-259811
α-helix2616-262813
α-helix2630-26345
Chain C: 21 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix6-127
α-helix30-4112
α-helix43-497
α-helix66-738
α-helix83-9917
α-helix111-12111
α-helix128-1369
α-helix146-15914
α-helix169-1724
α-helix177-1793
α-helix188-20114
α-helix209-2124
α-helix217-23014
α-helix238-25013
α-helix251-2533
α-helix254-2574
α-helix270-2789
α-helix283-2897
α-helix298-31821
α-helix329-34517
α-helix351-36010
Chain D: 15 helices, 2 β-strands
ElementResiduesLengthSheet
α-helix31-399
β-strand51110
β-strand54110
α-helix66-738
α-helix82-865
α-helix88-914
α-helix108-12114
α-helix126-13611
α-helix144-15714
α-helix169-1724
α-helix188-20013
α-helix209-2124
α-helix217-22711
α-helix239-25416
α-helix269-27810
α-helix280-2834
α-helix307-3148

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Serine/threonine-protein kinase ATRA, Bprotein2644Homo sapiensQ13535 (AlphaFold model)
ATR-interacting proteinC, Dprotein791Homo sapiensQ8WXE1 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>5YZ0_1 Serine/threonine-protein kinase ATR (chains A, B)
MGEHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRILTDVNVVAVELVKKTD
SQPTSVMLLDFIQHIMKSSPLMFVNVSGSHEAKGSCIEFSNWIITRLLRIAATPSCHLLH
KKICEVICSLLFLFKSKSPAIFGVLTKELLQLFEDLVYLHRRNVMGHAVEWPVVMSRFLS
QLDEHMGYLQSAPLQLMSMQNLEFIEVTLLMVLTRIIAIVFFRRQELLLWQIGCVLLEYG
SPKIKSLAISFLTELFQLGGLPAQPASTFFSSFLELLKHLVEMDTDQLKLYEEPLSKLIK
TLFPFEAEAYRNIEPVYLNMLLEKLCVMFEDGVLMRLKSDLLKAALCHLLQYFLKFVPAG
YESALQVRKVYVRNICKALLDVLGIEVDAEYLLGPLYAALKMESMEIIEEIQCQTQQENL
SSNSDGISPKRRRLSSSLNPSKRAPKQTEEIKHVDMNQKSILWSALKQKAESLQISLEYS
GLKNPVIEMLEGIAVVLQLTALCTVHCSHQNMNCRTFKDCQHKSKKKPSVVITWMSLDFY
TKVLKSCRSLLESVQKLDLEATIDKVVKIYDALIYMQVNSSFEDHILEDLCGMLSLPWIY
SHSDDGCLKLTTFAANLLTLSCRISDSYSPQAQSRCVFLLTLFPRRIFLEWRTAVYNWAL
QSSHEVIRASCVSGFFILLQQQNSCNRVPKILIDKVKDDSDIVKKEFASILGQLVCTLHG
MFYLTSSLTEPFSEHGHVDLFCRNLKATSQHECSSSQLKASVCKPFLFLLKKKIPSPVKL
AFIDNLHHLCKHLDFREDETDVKAVLGTLLNLMEDPDKDVRVAFSGNIKHILESLDSEDG
FIKELFVLRMKEAYTHAQISRNNELKDTLILTTGDIGRAAKGDLVPFALLHLLHCLLSKS
ASVSGAAYTEIRALVAAKSVKLQSFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADVR
KQDVAHQREMALNTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKASPAASALIRTLGKQ
LNVNRREILINNFKYIFSHLVCSCSKDELERALHYLKNETEIELGSLLRQDFQGLHNELL
LRIGEHYQQVFNGLSILASFASSDDPYQGPRDIISPELMADYLQPKLLGILAFFNMQLLS
SSVGIEDKKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDFPELCCRAWDCFV
RCLDHACLGSLLSHVIVALLPLIHIQPKETAAIFHYLIIENRDAVQDFLHEIYFLPDHPE
LKKIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQEKLIK
YATDSETVEPIISQLVTVLLKGCQDANSQARLLCGECLGELGAIDPGRLDFSTTETQGKD
FTFVTGVEDSSFAYGLLMELTRAYLAYADNSRAQDSAAYAIQELLSIYDCREMETNGPGH
QLWRRFPEHVREILEPHLNTRYKSSQKSTDWSGVKKPIYLSKLGSNFAEWSASWAGYLIT
KVRHDLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQEDQQEVYAEIMAVLKHDD
QHTINTQDIASDLCQLSTQTVFSMLDHLTQWARHKFQALKAEKCPHSKSNRNKVDSMVST
VDYEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQNIQEHLGFLQKLY
AAMHEPDGVAGVSAIRKAEPSLKEQILEHESLGLLRDATACYDRAIQLEPDQIIHYHGVV
KSMLGLGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQWDLVENYLAADGKSTTW
SVRLGQLLLSAKKRDITAFYDSLKLVRAEQIVPLSAASFERGSYQRGYEYIVRLHMLCEL
EHSIKPLFQHSPGDSSQEDSLNWVARLEMTQNSYRAKEPILALRRALLSLNKRPDYNEMV
GECWLQSARVARKAGHHQTAYNALLNAGESRLAELYVERAKWLWSKGDVHQALIVLQKGV
ELCFPENETPPEGKNMLIHGRAMLLVGRFMEETANFESNAIMKKYKDVTACLPEWEDGHF
YLAKYYDKLMPMVTDNKMEKQGDLIRYIVLHFGRSLQYGNQFIYQSMPRMLTLWLDYGTK
AYEWEKAGRSDRVQMRNDLGKINKVITEHTNYLAPYQFLTAFSQLISRICHSHDEVFVVL
MEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRCKEILNKAIHMKKSLEKFVGDATRLTD
KLLELCNKPVDGSSSTLSMSTHFKMLKKLVEEATFSEILIPLQSVMIPTLPSILGTHANH
ASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLME
FNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVY
MTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRS
TAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMV
NGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNET
GEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGW
TPYM
Sequence of entity 2 (C, D), FASTA
>5YZ0_2 ATR-interacting protein (chains C, D)
MAGTSAPGSKRRSEPPAPRPGPPPGTGHPPSKRARGFSAAAAPDPDDPFGAHGDFTADDL
EELDTLASQALSQCPAAARDVSSDHKVHRLLDGMSKNPSGKNRETVPIKDNFELEVLQAQ
YKELKEKMKVMEEEVLIKNGEIKILRDSLHQTESVLEEQRRSHFLLEQEKTQALSDKEKE
FSKKLQSLQSELQFKDAEMNELRTKLQTSERANKLAAPSVSHVSPRKNPSVVIKPEACSP
QFGKTSFPTKESFSANMSLPHPCQTESGYKPLVGREDSKPHSLRGDSIKQEEAQKSFVDS
WRQRSNTQGSILINLLLKQPLIPGSSLSLCHLLSSSSESPAGTPLQPPGFGSTLAGMSGL
RTTGSYDGSFSLSALREAQNLAFTGLNLVARNECSRDGDPAEGGRRAFPLCQLPGAVHFL
PLVQFFIGLHCQALQDLAAAKRSGAPGDSPTHSSCVSSGVETNPEDSVCILEGFSVTALS
ILQHLVCHSGAVVSLLLSGVGADSAAGEGNRSLVHRLSDGDMTSALRGVADDQGQHPLLK
MLLHLLAFSSAATGHLQASVLTQCLKVLVKLAENTSCDFLPRFQCVFQVLPKCLSPETPL
PSVLLAVELLSLLADHDQLAPQLCSHSEGCLLLLLYMYITSRPDRVALETQWLQLEQEVV
WLLAKLGVQSPLPPVTGSNCQCNVEVVRALTVMLHRQWLTVRRAGGPPRTDQQRRTVRCL
RDTVLLLHGLSQKDKLFMMHCVEVLHQFDQVMPGVSMLIRGLPDVTDCEEAALDDLCAAE
TDVEDPEVECG

Primary citation

Cryo-EM structure of human ATR-ATRIP complex. Rao, Q., Liu, M., Tian, Y. et al. Cell Res (2018) 28:143-156. DOI 10.1038/cr.2017.158 · PubMed

Other PDB entries of the same protein (UniProt Q13535 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

About this viewer

MolViewer shows 5YZ0 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.