6BUT: Full-length apo mammalian calmodulin

Solution structure of full-length apo mammalian calmodulin bound to the IQ motif of the human voltage-gated sodium channel NaV1.2. Determined by solution NMR. Released 19 Jun 2019.

Method: Solution NMR
Organism: Homo sapiens
Chains: 2
Atoms: 1,425
Mol. weight: 20.4 kDa
Released: 19 Jun 2019

Explore 6BUT in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6BUT contains 11 α-helices and 5 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	3-5	3
α-helix	6-17	12
β-strand	26-28	3	1
α-helix	32-38	7
α-helix	45-55	11
β-strand	62-64	3	1
α-helix	65-77	13
α-helix	82-92	11
β-strand	100-101	2	2
α-helix	102-111	10
α-helix	118-128	11
β-strand	129	1	2
β-strand	135-136	2	2
α-helix	138-146	9

Chain B: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	1902-1920	19
α-helix	1922-1924	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Calmodulin-1	A	protein	148	Homo sapiens	P0DP23 (AlphaFold model)
Sodium channel protein type 2 subunit alpha	B	protein	31	Homo sapiens	Q99250 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>6BUT_1 Calmodulin-1 (chains A)
ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGN
GTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEE
VDEMIREADIDGDGQVNYEEFVQMMTAK

Sequence of entity 2 (B), FASTA

>6BUT_2 Sodium channel protein type 2 subunit alpha (chains B)
GPGSKRKQEEVSAIIIQRAYRRYLLKQKVKK

Primary citation

Na V 1.2 EFL domain allosterically enhances Ca 2+ binding to sites I and II of WT and pathogenic calmodulin mutants bound to the channel CTD. Mahling, R., Hovey, L., Isbell, H.M. et al. Structure (2021). DOI 10.1016/j.str.2021.03.002 · PubMed

Other PDB entries of the same protein (UniProt P0DP23 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9MXD 1.17 Å, Human E104A calmodulin:MLCK RM20 complex
7BF1 1.24 Å, Ca2+-Calmodulin in complex with peptide from brain-type creatine kinase in extended 1:2…
6XXX 1.25 Å, 1.25 Angstrom crystal structure of Ca/CaM A102V:RyR2 peptide complex
4DJC 1.35 Å, 1.35 A crystal structure of the NaV1.5 DIII-IV-Ca/CaM complex
7BF2 1.43 Å, Ca2+-Calmodulin in complex with human muscle form creatine kinase peptide in extended…
2F3Y 1.45 Å, Calmodulin/IQ domain complex
2W73 1.45 Å, High-resolution structure of the complex between calmodulin and a peptide from…
4LZX 1.5 Å, Complex of IQCG and Ca2+-free CaM
5V03 1.58 Å, A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole…
9MVW 1.58 Å, Crystal structure of S101F calmodulin - CaM:RM20 analog complex
2F3Z 1.6 Å, Calmodulin/IQ-AA domain complex
6M7H 1.6 Å, Structure of calmodulin with KN93

Browse structure collections

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