6GE2: Exendin-4

exendin-4 based dual GLP-1/glucagon receptor agonist. Determined by solution NMR. Released 20 Jun 2018.

Method: Solution NMR
Organism: Heloderma suspectum
Chains: 1
Atoms: 338
Mol. weight: 4.8 kDa
Ligands: EVT
Released: 20 Jun 2018

Explore 6GE2 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6GE2 contains 2 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	5-29	25
α-helix	31-33	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Exendin-4	A	protein	40	Heloderma suspectum	P26349 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>6GE2_1 Exendin-4 (chains A)
HAQGTFTSDLSKQKDEQRAKLFIEWLAAGGPPSAKPPPKX

Ligands and cofactors

ID	Name	Formula	Copies
EVT	(2~{S})-2-[[(4~{S})-4-(hexadecanoylamino)-5-oxidanyl-5-oxidanylidene-pentanoyl]…	C26 H46 N2 O8	1

Primary citation

Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations. Evers, A., Bossart, M., Pfeiffer-Marek, S. et al. J Med Chem (2018) 61:5580-5593. DOI 10.1021/acs.jmedchem.8b00292 · PubMed

Other PDB entries of the same protein (UniProt P26349 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5OTT 1.92 Å, Extracellular domain of GLP-1 receptor in complex with exendin-4 variant Gly2Hcs/Thr5Hcs
3C5T 2.1 Å, Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular…
3C59 2.3 Å, Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular…
7LLL 3.7 Å, Exendin-4-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein
1JRJ Solution structure of exendin-4 in 30-vol% trifluoroethanol
2MJ9 Designed Exendin-4 analogues
2NAV NMR solution structure of Ex-4[1-16]/pl14a
2NAW NMR solution structure of Exendin-4/conotoxin chimera (Ex-4[1-27]/pl14a)
5NIQ exendin-4 variant with dual GLP-1 / glucagon receptor activity
6GDZ exendin-4 based dual GLP-1/glucagon receptor agonist
7MLL Solution structure of Exenatide (exendin-4) in 30-vol% trifluoroethanol using CS-Rosetta
9G0M Trp-cage fortified Tc5b-Exenatide chimera (Ex4-Tc5bER) at 288K

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