6HLQ: Yeast RNA polymerase I* elongation complex

Yeast RNA polymerase I* elongation complex bound to nucleotide analog GMPCPP. Determined by electron microscopy at 3.18 Å resolution. Released 3 Apr 2019.

Method: Electron microscopy
Resolution: 3.18 Å
Chains: 15
Atoms: 32,731
Mol. weight: 547.43 kDa
Released: 3 Apr 2019

Explore 6HLQ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6HLQ contains 181 α-helices and 229 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 85 helices, 67 β-strands

Element	Residues	Length	Sheet
β-strand	11	1	1
β-strand	14-15	2	2
β-strand	16-18	3	3
α-helix	23-26	4
β-strand	31	1	4
β-strand	38	1	5
α-helix	40-42	3
α-helix	43	1
β-strand	44	1	5
α-helix	45	1
β-strand	77-86	10	4
α-helix	91-98	8
β-strand	101	1	6
β-strand	108	1	6
α-helix	112-119	8
α-helix	121-126	6
α-helix	132-136	5
α-helix	177-198	22
α-helix	211-227	17
α-helix	241-242	2
β-strand	243-244	2	7
β-strand	252-253	2	7
α-helix	254-257	4
α-helix	263-265	3
β-strand	313-314	2	7
α-helix	317-330	14
α-helix	332-338	7
α-helix	348-350	3
α-helix	352-354	3
β-strand	356-362	7	4
α-helix	363-364	2
α-helix	365-368	4
α-helix	369-370	2
β-strand	371-373	3	8
β-strand	376-378	3	8
α-helix	381-398	18
α-helix	401-405	5
α-helix	414-438	25
α-helix	440-442	3
α-helix	452-454	3
β-strand	474-475	2	9
β-strand	479-486	8	10
β-strand	494-497	4	10
α-helix	499-504	6
β-strand	506-510	5	11
α-helix	511	1
α-helix	518-525	8
β-strand	533-537	5	11
β-strand	543-545	3	11
α-helix	551-558	8
β-strand	576-580	5	11
α-helix	581	1
β-strand	586-590	5	10
α-helix	597-599	3
β-strand	600-607	8	10
β-strand	614-616	3	10
β-strand	632-636	5	10
α-helix	641-644	4
β-strand	652	1	10
β-strand	658	1	12
β-strand	665	1	12
α-helix	672-680	9
β-strand	686-687	2	13
α-helix	689-697	9
α-helix	702-704	3
β-strand	719-721	3	14
β-strand	725	1	14
β-strand	726-727	2	13
α-helix	728-739	12
α-helix	741	1
α-helix	745-747	3
β-strand	748-752	5	15
α-helix	757-759	3
β-strand	768-772	5	15
β-strand	776-778	3	15
α-helix	793-800	8
α-helix	803-821	19
β-strand	826	1	16
α-helix	831-833	3
β-strand	835	1	17
α-helix	837-847	11
α-helix	848-850	3
α-helix	853-861	9
α-helix	873-883	11
α-helix	896-911	16
β-strand	916	1	17
α-helix	924-930	7
α-helix	937-944	8
β-strand	948-949	2	18
α-helix	970	1
α-helix	977-979	3
β-strand	981-982	2	18
α-helix	992-1011	20
α-helix	1017-1026	10
β-strand	1031	1	19
β-strand	1039	1	19
β-strand	1045	1	19
α-helix	1050-1052	3
β-strand	1055	1	20
α-helix	1057-1059	3
α-helix	1066-1071	6
α-helix	1073-1080	8
β-strand	1090	1	21
α-helix	1091-1107	17
α-helix	1123-1126	4
β-strand	1132	1	21
α-helix	1138-1150	13
α-helix	1164-1176	13
β-strand	1178	1	20
α-helix	1179-1180	2
α-helix	1185-1194	10
α-helix	1196-1198	3
α-helix	1219-1222	4
α-helix	1223-1227	5
β-strand	1238-1241	4	22
β-strand	1242	1	23
α-helix	1243	1
α-helix	1248-1252	5
β-strand	1261-1262	2	24
α-helix	1264-1266	3
β-strand	1267-1275	9	25
β-strand	1276	1	26
β-strand	1288	1	26
β-strand	1291-1296	6	25
α-helix	1299-1305	7
α-helix	1310-1316	7
α-helix	1317-1321	5
α-helix	1322-1334	13
α-helix	1443-1453	11
β-strand	1457	1	27
β-strand	1461-1462	2	25
β-strand	1469-1473	5	25
β-strand	1474	1	27
β-strand	1476	1	26
α-helix	1487-1493	7
β-strand	1497-1499	3	24
β-strand	1507-1508	2	22
α-helix	1513-1515	3
β-strand	1518-1521	4	22
β-strand	1536	1	23
α-helix	1538-1540	3
β-strand	1542-1543	2	22
α-helix	1546-1552	7
α-helix	1555-1567	13
α-helix	1581-1589	9
α-helix	1609-1615	7
α-helix	1618-1627	10
β-strand	1631-1632	2	2
α-helix	1639-1642	4
α-helix	1645-1647	3
α-helix	1650-1652	3
β-strand	1654-1660	7	28

Chain B: 49 helices, 81 β-strands

Element	Residues	Length	Sheet
β-strand	13-14	2	29
α-helix	21-26	6
α-helix	33	1
α-helix	36-39	4
α-helix	43-49	7
α-helix	56-58	3
α-helix	60-68	9
β-strand	71	1	30
β-strand	97	1	30
β-strand	99-104	6	31
β-strand	108-109	2	32
β-strand	119-120	2	32
α-helix	123-128	6
β-strand	134-145	12	31
β-strand	150-162	13	31
β-strand	164	1	33
α-helix	179-182	4
β-strand	194-196	3	33
β-strand	199-203	5	33
α-helix	204	1
β-strand	205-209	5	34
α-helix	210	1
β-strand	211	1	35
β-strand	215-216	2	35
α-helix	220-225	6
β-strand	229-239	11	35
β-strand	245-253	9	35
β-strand	258-263	6	35
β-strand	268-271	4	35
α-helix	273-280	8
α-helix	286-292	7
α-helix	300-316	17
α-helix	323-333	11
α-helix	346-356	11
α-helix	367-385	19
α-helix	390-393	4
α-helix	397-399	3
β-strand	400-403	4	34
α-helix	406-432	27
α-helix	443-450	8
α-helix	458-467	10
β-strand	485-487	3	33
α-helix	493-498	6
β-strand	502-504	3	34
α-helix	522-524	3
β-strand	528	1	36
β-strand	543-544	2	34
β-strand	545	1	36
β-strand	550-551	2	37
α-helix	570	1
β-strand	571-572	2	38
α-helix	573-575	3
β-strand	584-588	5	38
β-strand	591-596	6	38
α-helix	600-613	14
β-strand	625-629	5	38
β-strand	639-643	5	38
β-strand	649-650	2	37
β-strand	651-655	5	39
β-strand	660-664	5	39
α-helix	666-669	4
β-strand	674-675	2	39
β-strand	688-689	2	39
α-helix	693-695	3
α-helix	699-703	5
α-helix	707-709	3
β-strand	710	1	40
α-helix	712-721	10
β-strand	725	1	41
β-strand	740-744	5	42
β-strand	748	1	43
β-strand	752-753	2	29
α-helix	762-764	3
β-strand	769-772	4	44
β-strand	773-775	3	45
β-strand	777	1	16
β-strand	787-790	4	45
β-strand	801-810	10	42
β-strand	823-825	3	46
α-helix	834-837	4
β-strand	840	1	47
β-strand	846	1	47
α-helix	847	1
β-strand	851-852	2	42
β-strand	857-863	7	46
β-strand	868-873	6	46
β-strand	880-888	9	42
β-strand	900-909	10	42
β-strand	916-918	3	48
β-strand	925-926	2	48
β-strand	927-931	5	45
α-helix	933-935	3
β-strand	938	1	49
β-strand	947-949	3	45
α-helix	951-953	3
β-strand	959	1	40
α-helix	960-975	16
β-strand	978-980	3	29
α-helix	992-1003	12
β-strand	1010-1011	2	45
β-strand	1014	1	49
α-helix	1020	1
β-strand	1021	1	49
α-helix	1022	1
α-helix	1025	1
β-strand	1026-1027	2	45
β-strand	1030-1033	4	44
β-strand	1034-1035	2	48
β-strand	1036	1	41
β-strand	1045	1	10
β-strand	1052	1	50
β-strand	1059	1	50
α-helix	1060	1
α-helix	1068-1069	2
β-strand	1070-1071	2	9
α-helix	1073-1081	9
α-helix	1085-1089	5
α-helix	1090-1094	5
α-helix	1095-1097	3
β-strand	1098-1104	7	51
β-strand	1109	1	51
β-strand	1114-1115	2	52
β-strand	1126-1127	2	52
β-strand	1133-1134	2	53
β-strand	1158-1160	3	53
β-strand	1166-1168	3	53
β-strand	1173-1179	7	51
α-helix	1180-1191	12
β-strand	1194-1196	3	3
β-strand	1200	1	1

Chain C: 13 helices, 18 β-strands

Element	Residues	Length	Sheet
α-helix	33-39	7
β-strand	41	1	54
β-strand	46	1	55
β-strand	51-56	6	55
β-strand	57	1	54
α-helix	61-73	13
β-strand	76-88	13	56
α-helix	94-103	10
β-strand	106-107	2	57
β-strand	132-139	8	56
β-strand	141-142	2	58
α-helix	146-147	2
α-helix	153-156	4
β-strand	157-158	2	58
β-strand	161-162	2	59
α-helix	164-166	3
β-strand	168-170	3	56
α-helix	175-178	4
β-strand	185-186	2	57
β-strand	194-195	2	59
β-strand	201-212	12	56
α-helix	217-219	3
β-strand	222-235	14	55
α-helix	241-243	3
α-helix	244-247	4
β-strand	256-258	3	60
β-strand	265-267	3	60
α-helix	279-281	3
α-helix	283-285	3
β-strand	289-304	16	55
α-helix	310-330	21

Chain D: 2 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	21-24	4	28
β-strand	29-30	2	28
α-helix	33-48	16
α-helix	83-93	11

Chain E: 9 helices, 14 β-strands

Element	Residues	Length	Sheet
α-helix	5-25	21
β-strand	28	1	61
α-helix	32-35	4
α-helix	39-45	7
β-strand	47	1	62
β-strand	53	1	62
β-strand	60-62	3	63
β-strand	64	1	61
α-helix	66-71	6
β-strand	78-82	5	63
β-strand	87	1	64
α-helix	94-102	9
β-strand	107-112	6	63
β-strand	115	1	64
β-strand	131-136	6	63
α-helix	144-146	3
β-strand	152-155	4	65
α-helix	158-167	10
β-strand	177-178	2	65
α-helix	183-188	6
α-helix	190-191	2
β-strand	195-201	7	65
β-strand	207-214	8	65

Chain F: 5 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	57-70	14
β-strand	73	1	28
α-helix	74-75	2
β-strand	84	1	66
α-helix	87-102	16
α-helix	117-126	10
β-strand	132-137	6	28
β-strand	143-147	5	28
β-strand	152	1	66
α-helix	153	1

Chain G: 5 helices, 15 β-strands

Element	Residues	Length	Sheet
β-strand	38-49	12	28
α-helix	51-53	3
α-helix	57-61	5
α-helix	62-66	5
β-strand	73-74	2	28
β-strand	79-89	11	28
α-helix	90-91	2
β-strand	103-107	5	28
α-helix	108	1
β-strand	114-125	12	28
β-strand	132	1	67
β-strand	135-139	5	67
β-strand	145-149	5	67
β-strand	153-157	5	67
β-strand	167-168	2	68
β-strand	217-218	2	68
β-strand	224	1	68
β-strand	228	1	67
β-strand	232-237	6	67
β-strand	244-248	5	67

Chain H: 1 helix, 8 β-strands

Element	Residues	Length	Sheet
β-strand	4-16	13	14
β-strand	23-30	8	14
β-strand	37-43	7	14
β-strand	54-60	7	14
α-helix	89-92	4
β-strand	95-108	14	14
β-strand	111-118	8	14
β-strand	121-127	7	14
β-strand	139-145	7	14

4 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Primary citation

The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2. Tafur, L., Sadian, Y., Hanske, J. et al. Elife (2019) 8. DOI 10.7554/eLife.43204 · PubMed

Browse structure collections

About this viewer

MolViewer shows 6HLQ directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.