6HLS: Yeast apo RNA polymerase I*

Yeast apo RNA polymerase I*. Determined by electron microscopy at 3.21 Å resolution. Released 3 Apr 2019.

Method: Electron microscopy
Resolution: 3.21 Å
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Chains: 12
Atoms: 30,954
Mol. weight: 517.08 kDa
Ligands: ZN
Released: 3 Apr 2019

Explore 6HLS in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6HLS contains 181 α-helices and 221 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 79 helices, 59 β-strands

Element	Residues	Length	Sheet
β-strand	11-13	3	1
β-strand	14-15	2	2
β-strand	16-18	3	3
α-helix	23-26	4
β-strand	38	1	4
α-helix	40-42	3
α-helix	43	1
β-strand	44	1	4
α-helix	45	1
β-strand	77-86	10	5
α-helix	91-98	8
β-strand	101	1	6
β-strand	108	1	6
α-helix	112-124	13
α-helix	132-136	5
α-helix	178-198	21
α-helix	210-228	19
β-strand	243-244	2	7
β-strand	252-253	2	7
α-helix	255-257	3
α-helix	262-264	3
α-helix	317-330	14
α-helix	332-338	7
α-helix	348-350	3
β-strand	356-362	7	5
α-helix	363-364	2
α-helix	365-368	4
α-helix	381-404	24
α-helix	414-438	25
α-helix	452-454	3
α-helix	457-459	3
α-helix	467-470	4
β-strand	474-476	3	8
β-strand	479-486	8	9
β-strand	494-497	4	9
α-helix	499-504	6
β-strand	506-510	5	10
α-helix	518-525	8
β-strand	533-537	5	10
β-strand	544-545	2	10
α-helix	551-556	6
β-strand	576-580	5	10
α-helix	581	1
β-strand	586-590	5	9
α-helix	597-599	3
β-strand	600-607	8	9
β-strand	614-616	3	9
α-helix	618-620	3
α-helix	621-624	4
β-strand	632-636	5	9
α-helix	641-644	4
β-strand	652	1	9
β-strand	658	1	11
β-strand	665	1	11
α-helix	672-680	9
β-strand	686-687	2	12
α-helix	689-700	12
α-helix	702-704	3
β-strand	719	1	13
β-strand	725	1	13
β-strand	726-727	2	12
α-helix	729-738	10
α-helix	741	1
α-helix	745-747	3
β-strand	749-752	4	14
β-strand	768-772	5	14
β-strand	775-778	4	14
α-helix	794-801	8
α-helix	803-819	17
β-strand	826	1	15
α-helix	830-833	4
β-strand	835	1	16
α-helix	837-846	10
α-helix	849-851	3
α-helix	853-861	9
α-helix	873-883	11
α-helix	886-890	5
α-helix	895-911	17
β-strand	916	1	16
α-helix	927-930	4
α-helix	937-944	8
β-strand	948-949	2	17
α-helix	977-979	3
β-strand	981-982	2	17
α-helix	992-1007	16
α-helix	1019-1026	8
β-strand	1031	1	18
β-strand	1039	1	18
β-strand	1045	1	18
α-helix	1050-1052	3
β-strand	1055	1	19
α-helix	1057-1059	3
α-helix	1066-1071	6
α-helix	1073-1080	8
α-helix	1082-1084	3
β-strand	1090	1	20
α-helix	1093-1107	15
β-strand	1132	1	20
α-helix	1138-1150	13
α-helix	1163-1176	14
β-strand	1178	1	19
α-helix	1179-1180	2
β-strand	1184	1	18
α-helix	1185-1194	10
α-helix	1219-1222	4
α-helix	1223-1228	6
β-strand	1238-1241	4	21
β-strand	1242	1	22
α-helix	1249-1255	7
β-strand	1261-1262	2	23
α-helix	1263-1265	3
β-strand	1267-1275	9	24
β-strand	1289-1296	8	24
α-helix	1299-1305	7
α-helix	1310-1316	7
α-helix	1317-1321	5
α-helix	1322-1334	13
α-helix	1441-1453	13
β-strand	1461-1462	2	24
β-strand	1469-1475	7	24
α-helix	1487-1492	6
α-helix	1493-1495	3
β-strand	1497-1499	3	23
β-strand	1507-1508	2	21
α-helix	1513-1515	3
β-strand	1518-1521	4	21
β-strand	1536	1	22
α-helix	1538-1540	3
β-strand	1542-1543	2	21
α-helix	1546-1553	8
α-helix	1555-1565	11
α-helix	1568-1571	4
α-helix	1579-1589	11
α-helix	1609-1613	5
α-helix	1618-1627	10
β-strand	1631-1632	2	2
α-helix	1639-1642	4
β-strand	1654-1660	7	25

Chain B: 53 helices, 86 β-strands

Element	Residues	Length	Sheet
α-helix	22-26	5
α-helix	33	1
α-helix	36-40	5
α-helix	43-49	7
α-helix	50-52	3
α-helix	56-58	3
α-helix	61-68	8
β-strand	71	1	26
β-strand	96	1	27
β-strand	97	1	26
β-strand	99-104	6	28
α-helix	105-107	3
β-strand	108-109	2	29
β-strand	119-120	2	29
α-helix	123-128	6
β-strand	134-142	9	28
β-strand	144	1	27
β-strand	145	1	30
β-strand	150	1	30
β-strand	153-162	10	28
α-helix	177-181	5
β-strand	196	1	31
β-strand	199	1	31
β-strand	201-203	3	32
α-helix	204	1
β-strand	205-209	5	33
α-helix	210	1
β-strand	215-218	4	34
α-helix	220-224	5
β-strand	229-239	11	34
β-strand	245-253	9	34
β-strand	258-263	6	34
β-strand	268-272	5	34
α-helix	273-279	7
α-helix	286-292	7
α-helix	300-316	17
α-helix	323-333	11
α-helix	346-356	11
α-helix	367-385	19
α-helix	390-393	4
α-helix	397-399	3
β-strand	400-403	4	33
α-helix	407-434	28
α-helix	443-449	7
α-helix	458-467	10
β-strand	485-487	3	32
α-helix	493-498	6
β-strand	502-504	3	33
α-helix	522-524	3
β-strand	525	1	35
β-strand	528	1	35
β-strand	542-544	3	33
β-strand	545	1	35
β-strand	550-551	2	36
α-helix	555-557	3
α-helix	570	1
β-strand	571-572	2	37
β-strand	584-588	5	37
β-strand	591-596	6	37
α-helix	600-613	14
β-strand	625-629	5	37
β-strand	639-643	5	37
β-strand	649-650	2	36
β-strand	651-655	5	38
β-strand	660-664	5	38
α-helix	666-669	4
β-strand	674-675	2	38
α-helix	681-682	2
β-strand	688-689	2	38
α-helix	699-702	4
β-strand	710	1	39
α-helix	712-721	10
β-strand	725	1	40
α-helix	733-735	3
β-strand	740-744	5	41
β-strand	748	1	42
β-strand	752-753	2	43
α-helix	755-759	5
α-helix	762-764	3
β-strand	768-772	5	44
β-strand	773-775	3	45
β-strand	777	1	15
β-strand	787-790	4	45
β-strand	801-805	5	41
β-strand	806-810	5	46
β-strand	823-825	3	47
α-helix	834-838	5
β-strand	840	1	48
α-helix	845	1
β-strand	846	1	48
α-helix	847	1
β-strand	851-852	2	46
β-strand	857-863	7	47
β-strand	868-873	6	47
β-strand	880-888	9	46
α-helix	889-891	3
α-helix	896-898	3
β-strand	900-906	7	46
β-strand	907-909	3	41
β-strand	916-918	3	44
β-strand	924-926	3	44
β-strand	927-931	5	45
α-helix	933-935	3
β-strand	938-939	2	49
β-strand	947-949	3	45
β-strand	959	1	39
α-helix	960-975	16
β-strand	979-980	2	43
α-helix	992-1001	10
β-strand	1010-1011	2	45
β-strand	1013-1014	2	49
α-helix	1020	1
β-strand	1021	1	49
α-helix	1022	1
α-helix	1025	1
β-strand	1026-1027	2	45
β-strand	1030-1035	6	44
β-strand	1036	1	40
β-strand	1045-1047	3	9
β-strand	1052	1	50
α-helix	1058	1
β-strand	1059	1	50
α-helix	1060	1
β-strand	1061	1	51
β-strand	1068	1	51
β-strand	1069-1071	3	8
α-helix	1073-1081	9
α-helix	1086-1089	4
α-helix	1090-1094	5
β-strand	1098-1104	7	52
β-strand	1114-1115	2	53
β-strand	1126-1127	2	53
β-strand	1133-1134	2	54
β-strand	1158-1160	3	54
β-strand	1166-1168	3	54
β-strand	1173-1179	7	52
α-helix	1180-1192	13
β-strand	1194-1196	3	3
β-strand	1199-1200	2	1

Chain C: 12 helices, 17 β-strands

Element	Residues	Length	Sheet
α-helix	33-39	7
β-strand	41-46	6	55
β-strand	51-57	7	55
α-helix	61-73	13
β-strand	79-88	10	56
α-helix	94-102	9
β-strand	106-107	2	57
β-strand	132-139	8	56
β-strand	141-142	2	58
α-helix	146-147	2
α-helix	153-156	4
β-strand	157-158	2	58
β-strand	161-163	3	59
α-helix	164-166	3
β-strand	168-169	2	56
α-helix	175-178	4
β-strand	185-186	2	57
β-strand	192-195	4	59
β-strand	201-209	9	56
α-helix	217-219	3
β-strand	222-226	5	55
β-strand	229-235	7	55
α-helix	244-249	6
β-strand	256-258	3	60
β-strand	265-267	3	60
α-helix	278-281	4
α-helix	283-285	3
β-strand	289-304	16	55
α-helix	310-330	21

Chain D: 3 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	22	1	25
β-strand	29-30	2	25
α-helix	33-39	7
α-helix	45-48	4
α-helix	83-93	11

Chain E: 12 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	5-26	22
β-strand	28	1	61
α-helix	32-35	4
α-helix	39-45	7
β-strand	60-62	3	62
β-strand	64	1	61
α-helix	66-71	6
β-strand	78-82	5	62
β-strand	87-88	2	63
α-helix	92-102	11
β-strand	107-112	6	62
β-strand	115-116	2	63
α-helix	120-122	3
β-strand	131-136	6	62
α-helix	144-146	3
β-strand	152-155	4	64
α-helix	156-157	2
α-helix	158-167	10
α-helix	172-174	3
β-strand	177-178	2	64
α-helix	183-187	5
α-helix	190-191	2
β-strand	195-201	7	64
β-strand	207-214	8	64

Chain F: 5 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	57-71	15
β-strand	73	1	25
α-helix	76-78	3
β-strand	84	1	65
α-helix	87-101	15
α-helix	105-107	3
α-helix	117-124	8
β-strand	132-137	6	25
β-strand	143-147	5	25
β-strand	152	1	65

Chain G: 4 helices, 13 β-strands

Element	Residues	Length	Sheet
β-strand	38-49	12	25
α-helix	51-53	3
α-helix	57-61	5
α-helix	62-66	5
β-strand	72-73	2	25
β-strand	80-90	11	25
α-helix	91	1
β-strand	103-107	5	25
β-strand	114-125	12	25
β-strand	132-133	2	66
β-strand	136-137	2	67
β-strand	147-149	3	67
β-strand	153-155	3	67
β-strand	167-169	3	68
β-strand	216-218	3	68
β-strand	231-237	7	66
β-strand	244-248	5	66

Chain H: 1 helix, 8 β-strands

Element	Residues	Length	Sheet
β-strand	4-16	13	13
β-strand	23-30	8	13
β-strand	37-43	7	13
β-strand	54-60	7	13
α-helix	89-92	4
β-strand	95-108	14	13
β-strand	111-118	8	13
β-strand	121-127	7	13
β-strand	139-145	7	13

4 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase I subunit RPA190	A	protein	1664	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P10964 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA135	B	protein	1203	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P22138 (AlphaFold model)
DNA-directed RNA polymerases I and III subunit RPAC1	C	protein	335	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P07703 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA14	D	protein	137	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P50106 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	215	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P20434
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	155	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P20435
DNA-directed RNA polymerase I subunit RPA43	G	protein	326	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P46669
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	146	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P20436
DNA-directed RNA polymerase I subunit RPA12	I	protein	125	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P32529
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	70	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P22139
DNA-directed RNA polymerases I and III subunit RPAC2	K	protein	142	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P28000
DNA-directed RNA polymerases I, II, and III subunit RPABC4	L	protein	70	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P40422

Sequence of entity 1 (A), FASTA

>6HLS_1 DNA-directed RNA polymerase I subunit RPA190 (chains A)
MDISKPVGSEITSVDFGILTAKEIRNLSAKQITNPTVLDNLGHPVSGGLYDLALGAFLRN
LCSTCGLDEKFCPGHQGHIELPVPCYNPLFFNQLYIYLRASCLFCHHFRLKSVEVHRYAC
KLRLLQYGLIDESYKLDEITLGSLNSSMYTDDEAIEDNEDEMDGEGSKQSKDISSTLLNE
LKSKRSEYVDMAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLSRGKCDNCGMFS
PKFRKDGFTKIFETALNEKQITNNRVKGFIRQDMIKKQKQAKKLDGSNEASANDEESFDV
GRNPTTRPKTGSTYILSTEVKNILDTVFRKEQCVLQYVFHSRPNLSRKLVKADSFFMDVL
VVPPTRFRLPSKLGEEVHENSQNQLLSKVLTTSLLIRDLNDDLSKLQKDKVSLEDRRVIF
SRLMNAFVTIQNDVNAFIDSTKAQGRTSGKVPIPGVKQALEKKEGLFRKHMMGKRVNYAA
RSVISPDPNIETNEIGVPPVFAVKLTYPEPVTAYNIAELRQAVINGPDKWPGATQIQNED
GSLVSLIGMSVEQRKALANQLLTPSSNVSTHTLNKKVYRHIKNRDVVLMNRQPTLHKASM
MGHKVRVLPNEKTLRLHYANTGAYNADFDGDEMNMHFPQNENARAEALNLANTDSQYLTP
TSGSPVRGLIQDHISAGVWLTSKDSFFTREQYQQYIYGCIRPEDGHTTRSKIVTLPPTIF
KPYPLWTGKQIITTVLLNVTPPDMPGINLISKNKIKNEYWGKGSLENEVLFKDGALLCGI
LDKSQYGASKYGIVHSLHEVYGPEVAAKVLSVLGRLFTNYITATAFTCGMDDLRLTAEGN
KWRTDILKTSVDTGREAAAEVTNLDKDTPADDPELLKRLQEILRDNNKSGILDAVTSSKV
NAITSQVVSKCVPDGTMKKFPCNSMQAMALSGAKGSNVNVSQIMCLLGQQALEGRRVPVM
VSGKTLPSFKPYETDAMAGGYVKGRFYSGIKPQEYYFHCMAGREGLIDTAVKTSRSGYLQ
RCLTKQLEGVHVSYDNSIRDADGTLVQFMYGGDAIDITKESHMTQFEFCLDNYYALLKKY
NPSALIEHLDVESALKYSKKTLKYRKKHSKEPHYKQSVKYDPVLAKYNPAKYLGSVSENF
QDKLESFLDKNSKLFKSSDGVNEKKFRALMQLKYMRSLINPGEAVGIIASQSVGEPSTQM
TLNTFHFAGHGAANVTLGIPRLREIVMTASAAIKTPQMTLPIWNDVSDEQADTFCKSISK
VLLSEVIDKVIVTETTGTSNTAGGNAARSYVIHMRFFDNNEYSEEYDVSKEELQNVISNQ
FIHLLEAAIVKEIKKQKRTTGPDIGVAVPRLQTDVANSSSNSKRLEEDNDEEQSHKKTKQ
AVSYDEPDEDEIETMREAEKSSDEEGIDSDKESDSDSEDEDVDMNEQINKSIVEANNNMN
KVQRDRQSAIISHHRFITKYNFDDESGKWCEFKLELAADTEKLLMVNIVEEICRKSIIRQ
IPHIDRCVHPEPENGKRVLVTEGVNFQAMWDQEAFIDVDGITSNDVAAVLKTYGVEAARN
TIVNEINNVFSRYAISVSFRHLDLIADMMTRQGTYLAFNRQGMETSTSSFMKMSYETTCQ
FLTKAVLDNEREQLDSPSARIVVGKLNNVGTGSFDVLAKVPNAA

Sequence of entity 2 (B), FASTA

>6HLS_2 DNA-directed RNA polymerase I subunit RPA135 (chains B)
MSKVIKPPGQARTADFRTLERESRFINPPKDKSAFPLLQEAVQPHIGSFNALTEGPDGGL
LNLGVKDIGEKVIFDGKPLNSEDEISNSGYLGNKLSVSVEQVSIAKPMSNDGVSSAVERK
VYPSESRQRLTSYRGKLLLKLKWSVNNGEENLFEVRDCGGLPVMLQSNRCHLNKMSPYEL
VQHKEESDEIGGYFIVNGIEKLIRMLIVQRRNHPMAIIRPSFANRGASYSHYGIQIRSVR
PDQTSQTNVLHYLNDGQVTFRFSWRKNEYLVPVVMILKALCHTSDREIFDGIIGNDVKDS
FLTDRLELLLRGFKKRYPHLQNRTQVLQYLGDKFRVVFQASPDQSDLEVGQEVLDRIVLV
HLGKDGSQDKFRMLLFMIRKLYSLVAGECSPDNPDATQHQEVLLGGFLYGMILKEKIDEY
LQNIIAQVRMDINRGMAINFKDKRYMSRVLMRVNENIGSKMQYFLSTGNLVSQSGLDLQQ
VSGYTVVAEKINFYRFISHFRMVHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPDGSPCG
LLNHFAHKCRISTQQSDVSRIPSILYSLGVAPASHTFAAGPSLCCVQIDGKIIGWVSHEQ
GKIIADTLRYWKVEGKTPGLPIDLEIGYVPPSTRGQYPGLYLFGGHSRMLRPVRYLPLDK
EDIVGPFEQVYMNIAVTPQEIQNNVHTHVEFTPTNILSILANLTPFSDFNQSPRNMYQCQ
MGKQTMGTPGVALCHRSDNKLYRLQTGQTPIVKANLYDDYGMDNFPNGFNAVVAVISYTG
YDMDDAMIINKSADERGFGYGTMYKTEKVDLALNRNRGDPITQHFGFGNDEWPKEWLEKL
DEDGLPYIGTYVEEGDPICAYFDDTLNKTKIKTYHSSEPAYIEEVNLIGDESNKFQELQT
VSIKYRIRRTPQIGDKFSSRHGQKGVCSRKWPTIDMPFSETGIQPDIIINPHAFPSRMTI
GMFVESLAGKAGALHGIAQDSTPWIFNEDDTPADYFGEQLAKAGYNYHGNEPMYSGATGE
ELRADIYVGVVYYQRLRHMVNDKFQVRSTGPVNSLTMQPVKGRKRHGGIRVGEMERDALI
GHGTSFLLQDRLLNSSDYTQASVCRECGSILTTQQSVPRIGSISTVCCRRCSMRFEDAKK
LLTKSEDGEKIFIDDSQIWEDGQGNKFVGGNETTTVAIPFVLKYLDSELSAMGIRLRYNV
EPK

Sequence of entity 3 (C), FASTA

>6HLS_3 DNA-directed RNA polymerases I and III subunit RPAC1 (chains C)
MSNIVGIEYNRVTNTTSTDFPGFSKDAENEWNVEKFKKDFEVNISSLDAREANFDLINID
TSIANAFRRIMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLVPLKVDPDMLTWVDSNL
PDDEKFTDENTIVLSLNVKCTRNPDAPKGSTDPKELYNNAHVYARDLKFEPQGRQSTTFA
DCPVVPADPDILLAKLRPGQEISLKAHCILGIGGDHAKFSPVSTASYRLLPQINILQPIK
GESARRFQKCFPPGVIGIDEGSDEAYVKDARKDTVSREVLRYEEFADKVKLGRVRNHFIF
NVESAGAMTPEEIFFKSVRILKNKAEYLKNCPITQ

Sequence of entity 4 (D), FASTA

>6HLS_4 DNA-directed RNA polymerase I subunit RPA14 (chains D)
MMKGSRRTGNNTATTLNTPVVIHATQLPQHVSTDEVLQFLESFIDEKENIIDSTTMNTIS
GNAADADAAAVANTSLNIDTNLSSSISQLKRIQRDFKGLPPAQDFSAAPIQVSTTEKKET
SIGVSATGGKKTTFADE

Sequence of entity 5 (E), FASTA

>6HLS_5 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSF
QANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSA
MKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQR
ADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM

Sequence of entity 6 (F), FASTA

>6HLS_6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQ
HEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRI
AMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL

Sequence of entity 7 (G), FASTA

>6HLS_7 DNA-directed RNA polymerase I subunit RPA43 (chains G)
MSQVKRANENRETARFIKKHKKQVTNPIDEKNGTSNCIVRVPIALYVSLAPMYLENPLQG
VMKQHLNPLVMKYNNKVGGVVLGYEGLKILDADPLSKEDTSEKLIKITPDTPFGFTWCHV
NLYVWQPQVGDVLEGYIFIQSASHIGLLIHDAFNASIKKNNIPVDWTFVHNDVEEDADVI
NTDENNGNNNNEDNKDSNGGSNSLGKFSFGNRSLGHWVDSNGEPIDGKLRFTVRNVHTTG
RVVSVDGTLISDADEEGNGYNSSRSQAESLPIVSNKKIVFDDEVSIENKESHKELDLPEV
KEDNGSEIVYEENTSESNDGESSDSD

Sequence of entity 8 (H), FASTA

>6HLS_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MSNTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTLDINVELFPVAAQDSLTVTIA
SSLNLEDTPANDSSATRSWRPPQAGDRSLADDYDYVMYGTAYKFEEVSKDLIAVYYSFGG
LLMRLEGNYRNLNNLKQENAYLLIRR

Sequence of entity 9 (I), FASTA

>6HLS_9 DNA-directed RNA polymerase I subunit RPA12 (chains I)
MSVVGSLIFCLDCGDLLENPNAVLGSNVECSQCKAIYPKSQFSNLKVVTTTADDAFPSSL
RAKKSVVKTSLKKNELKDGATIKEKCPQCGNEEMNYHTLQLRSADEGATVFYTCTSCGYK
FRTNN

Sequence of entity 10 (J), FASTA

>6HLS_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLGLKRYCCRRMILTHVDLIEKF
LRYNPLEKRD

Sequence of entity 11 (K), FASTA

>6HLS_11 DNA-directed RNA polymerases I and III subunit RPAC2 (chains K)
MTEDIEQKKTATEVTPQEPKHIQEEEEQDVDMTGDEEQEEEPDREKIKLLTQATSEDGTS
ASFQIVEEDHTLGNALRYVIMKNPDVEFCGYSIPHPSENLLNIRIQTYGETTAVDALQKG
LKDLMDLCDVVESKFTEKIKSM

Sequence of entity 12 (L), FASTA

>6HLS_12 DNA-directed RNA polymerases I, II, and III subunit RPABC4 (chains L)
MSREGFQIPTNLDAAAAGTSQARTATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKAR
TKRLVQFEAR

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	7

Primary citation

The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2. Tafur, L., Sadian, Y., Hanske, J. et al. Elife (2019) 8. DOI 10.7554/eLife.43204 · PubMed

Other PDB entries of the same protein (UniProt P10964 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6RUI 2.7 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 2
9G1V 2.7 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site
4C2M 2.8 Å, Structure of RNA polymerase I at 2.8 A resolution
9G27 2.8 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site, pre-translocation…
6RQL 2.9 Å, RNA Polymerase I Closed Conformation 2 (CC2)
4C3I 3.0 Å, Structure of 14-subunit RNA polymerase I at 3.0 A resolution, crystal form C2-100
6RWE 3.0 Å, RNA Polymerase I Open Complex conformation 2
6RRD 3.1 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 1
6HLQ 3.18 Å, Yeast RNA polymerase I* elongation complex bound to nucleotide analog GMPCPP
6HLR 3.18 Å, Yeast RNA polymerase I elongation complex bound to nucleotide analog GMPCPP (core focused)
9G2B 3.2 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site, 12-subunit
4C3H 3.27 Å, Structure of 14-subunit RNA polymerase I at 3.27 A resolution, crystal form C2-93

Browse structure collections

About this viewer

MolViewer shows 6HLS directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.