6RQH: RNA Polymerase I Closed Conformation 1

RNA Polymerase I Closed Conformation 1 (CC1). Determined by electron microscopy at 3.7 Å resolution. Released 11 Dec 2019.

Method: Electron microscopy
Resolution: 3.7 Å
Organisms: synthetic construct, Saccharomyces cerevisiae
Chains: 20
Atoms: 50,851
Mol. weight: 927.83 kDa
Released: 11 Dec 2019

Explore 6RQH in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6RQH contains 268 α-helices and 305 β-strands across 18 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 74 helices, 65 β-strands

Element	Residues	Length	Sheet
β-strand	13-18	6	30
α-helix	24-27	4
β-strand	34	1	31
β-strand	38	1	32
β-strand	44	1	32
β-strand	48	1	31
β-strand	77-86	10	33
α-helix	90-93	4
α-helix	95-99	5
β-strand	101	1	34
β-strand	108	1	34
α-helix	114-124	11
α-helix	136-138	3
α-helix	182-198	17
α-helix	210-226	17
β-strand	243-245	3	35
β-strand	251-253	3	35
α-helix	258-267	10
β-strand	313-314	2	35
α-helix	318-328	11
α-helix	332-338	7
α-helix	343-344	2
α-helix	348-350	3
β-strand	356-362	7	33
α-helix	365-367	3
β-strand	372-373	2	36
β-strand	376-377	2	36
α-helix	381-404	24
α-helix	420-438	19
α-helix	440-442	3
α-helix	467-471	5
β-strand	475-476	2	37
β-strand	479-483	5	38
β-strand	486	1	39
β-strand	494-497	4	39
α-helix	499-502	4
β-strand	506-510	5	40
α-helix	517-525	9
β-strand	533-537	5	40
β-strand	543-545	3	40
α-helix	551-557	7
β-strand	576-580	5	40
α-helix	581	1
β-strand	586-588	3	39
β-strand	591	1	38
α-helix	597-599	3
β-strand	602-607	6	39
β-strand	615-616	2	39
α-helix	619-621	3
β-strand	632-636	5	38
β-strand	652	1	39
β-strand	658	1	41
β-strand	665	1	41
α-helix	672-675	4
α-helix	677-680	4
β-strand	686-687	2	42
α-helix	689-699	11
β-strand	719	1	43
β-strand	726-727	2	42
α-helix	728-738	11
β-strand	748-751	4	44
β-strand	769-772	4	44
β-strand	775-778	4	44
α-helix	783-786	4
α-helix	794-800	7
α-helix	803-819	17
β-strand	826	1	45
α-helix	831-833	3
β-strand	835	1	46
α-helix	838-848	11
α-helix	851-861	11
α-helix	875-881	7
α-helix	891-900	10
α-helix	902-908	7
β-strand	916	1	46
α-helix	924-929	6
α-helix	937-944	8
β-strand	948-949	2	47
β-strand	981-982	2	47
α-helix	992-1003	12
α-helix	1006-1011	6
α-helix	1017-1023	7
β-strand	1031-1032	2	48
β-strand	1038-1039	2	48
β-strand	1045-1047	3	48
α-helix	1050-1052	3
α-helix	1060-1062	3
α-helix	1066-1071	6
α-helix	1073-1079	7
β-strand	1090	1	49
α-helix	1094-1103	10
α-helix	1113-1115	3
α-helix	1123-1125	3
β-strand	1132	1	49
α-helix	1138-1150	13
α-helix	1164-1176	13
α-helix	1185-1189	5
α-helix	1195-1198	4
α-helix	1219-1226	8
β-strand	1238-1241	4	50
β-strand	1242	1	51
α-helix	1249-1258	10
β-strand	1262	1	52
α-helix	1263-1265	3
β-strand	1267-1269	3	53
β-strand	1271-1276	6	54
β-strand	1288-1293	6	54
β-strand	1295-1296	2	53
α-helix	1299-1305	7
α-helix	1310-1316	7
α-helix	1317-1321	5
α-helix	1322-1338	17
α-helix	1342-1343	2
α-helix	1346-1347	2
β-strand	1348	1	55
α-helix	1369-1378	10
α-helix	1390-1392	3
α-helix	1441-1451	11
β-strand	1461-1462	2	54
β-strand	1470-1475	6	54
α-helix	1486-1492	7
β-strand	1497	1	52
β-strand	1507-1508	2	50
β-strand	1513	1	56
β-strand	1516	1	56
β-strand	1518-1521	4	50
α-helix	1526-1530	5
β-strand	1536	1	51
β-strand	1542-1543	2	50
α-helix	1546-1552	7
α-helix	1556-1570	15
α-helix	1579-1589	11
α-helix	1600-1603	4
α-helix	1609-1613	5
α-helix	1620-1626	7
β-strand	1631-1632	2	30
α-helix	1637-1640	4
α-helix	1645-1647	3
β-strand	1654-1659	6	57

Chain B: 52 helices, 78 β-strands

Element	Residues	Length	Sheet
α-helix	22-25	4
α-helix	36-39	4
α-helix	43-50	8
α-helix	59-64	6
α-helix	65-67	3
β-strand	71-73	3	58
α-helix	85-88	4
β-strand	95-97	3	58
β-strand	99-104	6	58
β-strand	108-109	2	59
β-strand	119-120	2	59
α-helix	125-128	4
β-strand	134-145	12	58
β-strand	150-162	13	58
α-helix	177-182	6
β-strand	194-196	3	60
β-strand	199-203	5	60
α-helix	204-205	2
β-strand	206-209	4	61
α-helix	210	1
β-strand	215	1	62
α-helix	220-225	6
β-strand	229	1	63
β-strand	234	1	64
β-strand	235	1	62
β-strand	237	1	65
β-strand	247	1	65
β-strand	250	1	64
β-strand	253	1	63
β-strand	259-262	4	64
β-strand	268	1	55
β-strand	269-272	4	64
α-helix	273-280	8
α-helix	285-292	8
α-helix	302-316	15
α-helix	323-333	11
α-helix	346-356	11
α-helix	371-374	4
α-helix	376-385	10
α-helix	390-393	4
β-strand	400-403	4	61
α-helix	405-416	12
α-helix	421-429	9
α-helix	443-450	8
α-helix	458-461	4
β-strand	485-487	3	60
α-helix	493-497	5
β-strand	502	1	66
β-strand	504	1	61
α-helix	515-517	3
α-helix	522-524	3
β-strand	528	1	67
β-strand	544	1	66
β-strand	545	1	67
β-strand	550-551	2	68
α-helix	562-565	4
α-helix	570	1
β-strand	571-572	2	69
β-strand	584-588	5	69
β-strand	591-596	6	69
α-helix	598-613	16
β-strand	625-629	5	69
α-helix	637-638	2
β-strand	639-643	5	69
β-strand	649-650	2	68
β-strand	651-655	5	70
β-strand	660-664	5	70
α-helix	669-671	3
β-strand	674-675	2	70
β-strand	688-689	2	70
α-helix	693-695	3
α-helix	699-702	4
α-helix	712-714	3
α-helix	716-723	8
β-strand	725	1	71
α-helix	733-735	3
β-strand	741-744	4	72
β-strand	748	1	73
β-strand	753	1	74
α-helix	756-759	4
α-helix	762-764	3
β-strand	769-775	7	75
β-strand	777	1	45
β-strand	786-789	4	75
β-strand	790	1	76
α-helix	791-794	4
β-strand	801-810	10	72
α-helix	819-821	3
β-strand	824-825	2	77
α-helix	836-838	3
β-strand	840	1	78
β-strand	846	1	78
α-helix	847	1
β-strand	852	1	79
β-strand	857-862	6	77
β-strand	869-873	5	77
β-strand	880	1	79
β-strand	881-885	5	72
β-strand	886-887	2	80
α-helix	897-898	2
β-strand	900-909	10	72
β-strand	916-918	3	75
β-strand	924-927	4	75
β-strand	931	1	76
β-strand	947-949	3	75
α-helix	954-957	4
α-helix	960-968	9
α-helix	970-972	3
β-strand	980	1	74
α-helix	992-995	4
α-helix	998-1001	4
β-strand	1027-1035	9	75
β-strand	1036	1	71
β-strand	1045-1047	3	38
α-helix	1058-1061	4
β-strand	1062	1	81
β-strand	1067	1	81
β-strand	1069-1070	2	37
α-helix	1073-1079	7
α-helix	1089-1092	4
β-strand	1102-1104	3	82
β-strand	1113-1115	3	83
β-strand	1117	1	84
β-strand	1126-1128	3	83
β-strand	1132-1134	3	84
β-strand	1159-1160	2	84
β-strand	1166-1169	4	84
β-strand	1173-1175	3	82
α-helix	1180-1190	11
β-strand	1194-1199	6	30

Chain C: 8 helices, 16 β-strands

Element	Residues	Length	Sheet
α-helix	33-37	5
β-strand	41-46	6	85
β-strand	52-57	6	85
α-helix	61-72	12
β-strand	77-88	12	86
α-helix	94-102	9
β-strand	106	1	87
α-helix	122-125	4
β-strand	133-139	7	86
β-strand	141-142	2	88
β-strand	157-158	2	88
β-strand	161-163	3	89
α-helix	164-166	3
β-strand	168-170	3	86
β-strand	186	1	87
β-strand	192-195	4	89
β-strand	201-211	11	86
β-strand	225-235	11	85
α-helix	242-248	7
β-strand	256-257	2	90
β-strand	266-267	2	90
α-helix	279-281	3
β-strand	289-302	14	85
α-helix	310-329	20

Chain D: 4 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	7-10	4
β-strand	23-24	2	91
β-strand	29-30	2	91
α-helix	34-43	10
α-helix	83-89	7
α-helix	94-96	3

Chain E: 12 helices, 14 β-strands

Element	Residues	Length	Sheet
α-helix	4-26	23
β-strand	28	1	92
α-helix	32-35	4
α-helix	39-46	8
β-strand	47	1	93
β-strand	53	1	93
β-strand	60-62	3	94
β-strand	64	1	92
α-helix	66-69	4
β-strand	78-81	4	94
β-strand	87-88	2	95
α-helix	90-103	14
β-strand	107-112	6	94
β-strand	115-116	2	95
α-helix	120-123	4
β-strand	131-136	6	94
α-helix	137-139	3
β-strand	152-155	4	96
α-helix	158-165	8
α-helix	172-174	3
α-helix	176	1
β-strand	177-178	2	96
α-helix	179	1
α-helix	185-188	4
β-strand	195-202	8	96
β-strand	206-214	9	96

Chain F: 5 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	59-68	10
β-strand	73	1	57
α-helix	76-78	3
β-strand	84	1	97
α-helix	90-101	12
α-helix	105-107	3
α-helix	117-125	9
β-strand	132-137	6	57
β-strand	143-147	5	57
β-strand	152	1	97

Chain G: 8 helices, 18 β-strands

Element	Residues	Length	Sheet
α-helix	17-20	4
α-helix	34-36	3
β-strand	38-47	10	91
α-helix	51-53	3
α-helix	59-61	3
α-helix	62-66	5
β-strand	73	1	91
β-strand	80-84	5	91
β-strand	88-89	2	91
α-helix	90-91	2
β-strand	104-107	4	57
α-helix	108	1
β-strand	114-115	2	57
β-strand	116-125	10	91
β-strand	132-140	9	98
β-strand	144-148	5	98
β-strand	149	1	99
β-strand	153	1	99
β-strand	154-155	2	100
β-strand	156-158	3	98
α-helix	159-161	3
β-strand	167-170	4	101
β-strand	215-218	4	101
β-strand	228-233	6	98
β-strand	244-245	2	100
β-strand	247-248	2	98

Chain H: 3 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	4	1	43
β-strand	10-16	7	102
β-strand	23-30	8	102
β-strand	37-43	7	102
β-strand	56-57	2	43
β-strand	60	1	43
α-helix	79-82	4
α-helix	90-92	3
β-strand	95-99	5	43
β-strand	100-106	7	102
β-strand	112-117	6	102
β-strand	122-126	5	102
α-helix	130-132	3
β-strand	140-145	6	43

10 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Template strand	T	DNA	70	synthetic construct
Nontemplate strand	U	DNA	70	synthetic construct
RNA polymerase I-specific transcription initiation factor RRN7	Q	protein	514	Saccharomyces cerevisiae	P40992 (AlphaFold model)
RNA polymerase I-specific transcription initiation factor RRN6	S	protein	894	Saccharomyces cerevisiae	P32786 (AlphaFold model)
RNA polymerase I-specific transcription initiation factor RRN11	R	protein	507	Saccharomyces cerevisiae	Q04712 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA49	M	protein	415	Saccharomyces cerevisiae	Q01080 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA190	A	protein	1664	Saccharomyces cerevisiae	P10964
DNA-directed RNA polymerase I subunit RPA135	B	protein	1203	Saccharomyces cerevisiae	P22138
DNA-directed RNA polymerases I and III subunit RPAC1	C	protein	335	Saccharomyces cerevisiae	P07703
DNA-directed RNA polymerase I subunit RPA14	D	protein	137	Saccharomyces cerevisiae	P50106
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	215	Saccharomyces cerevisiae	P20434
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	155	Saccharomyces cerevisiae	P20435

8 more molecules are not listed.

Sequence of entity 1 (T), FASTA

>6RQH_1 Template strand (chains T)
GTCTTCAACTGCTTTCGCATGAAGTACCTCCCAACTACTTTTCCTCACACTTGTACTCCA
TGACTAAACC

Sequence of entity 2 (U), FASTA

>6RQH_2 Nontemplate strand (chains U)
GGTTTAGTCATGGAGTACAAGTGTGAGGAAAAGTAGTTGGGAGGTACTTCATGCGAAAGC
AGTTGAAGAC

Sequence of entity 3 (Q), FASTA

>6RQH_3 RNA polymerase I-specific transcription initiation factor RRN7 (chains Q)
MSTFIRGPICGTDNCPSRLWRIIDGRRTCQYGHVMEGDVEFNDDEDDLNGLGAGVITRRL
NLTTNATGSFQSSQLTNSQLLQQQQRQSHKKFKKLIGHEAKLLFLKSFQFILKRQIRWLI
TEMRFPKEFEHVAKIIWLKILKTINDQPQEELKLQLHMTSTISILYLASTHLSLPVYTCD
YIKWICTAKMPYFQASEILPKSWRIQLPNYYVSILEGSISPFNGQLYNKIALTCGMIHFK
EFFNSEISCQGLLLKLVMQCALPPEFYFYTKQVIEFEETDIRNLTLWERTDERHTGRVSN
HAELRVLSYFMLTINWMLSFDRDRQYPLKWILSLTESLTQRTTTSESIGRNIVKVVYPDK
PTSSDYFQWSEEETLEFLKWMEKQFLPTQTKSLHNENGSMEMTIDQKIARRKLYKIFPLD
REANHDGEFNDSTHQLTFIEDLQERYAKQTPFFESNKIRDSLNYQEANPPARKEAIGRLL
THIASQLLVDFAISKEQLKDCISRIKNACLHRMN

Sequence of entity 4 (S), FASTA

>6RQH_4 RNA polymerase I-specific transcription initiation factor RRN6 (chains S)
MSEGQIPSSDVLGSQLGVGVQGASLYCPQENYTTKKQEKPQWLRPVDDTLAEDALDLHIV
VKSLLCDTAIRYISDDKVLQESDADDDLITSDIDEDTDNQGDTSIVVNPVIPVVPKDVHF
FKKVDVGNDSMFGVNCDTPVSFQDYIPSDLLRNLDDTLQESTNSSRPMQDAFFWDPTVAN
RLDSQYIQTASDLRNYRDGTEIIAYASGKTGSVLNIAVLTRQNTLHLNRHNNVTSIELHS
PIKSIKIPGASESIGRRSNLVGIITENSFQIFRIESVHSRSCDVMVSSSEPLYFVEIDDL
QVVDFAFNPWDLQQFAIIDIKGNWSIGRIPKNFNNNNKRKLQLIDNLHGTIFDPEELSSW
KRIEWFSHFQKILVFDRSKMIEIDFMNNWQTEVVQAKAWSNIRDYKRIDDKNGILLTSRE
IIIVGASESNDPVRRISWKHDLDPDDTTLRITVQKVKKPDHILLVAFVYSMRHKRIYMHV
FSHRKANLFQSLGCSTVLEIPGGTPTGIETILTLDHIDDESRREEDADENFELVVDFLVK
LRNSSEVYYYALSNTQNSEPNKQETPIIVDHPEWASLFNNADEREKESIGALVSQIKLKE
RERISRVQNLIEHENSHDEDKYLQDLGYRLSIATNELLESWQKTKDESILSGSLSHSKLK
NLLENSDSFASIPEFSSLLDQFFQYYQDQDVTFIGFEKLLHLFLHEDVPGLDIFYNKLLQ
CWVLVSPQAELLTKEIVKDIIWSLARLEKPSLFEPIQNEISRSLSGPYQDIISSWDMDDI
NEEDESNEFNFDSQFSAPFNGRPPFNLNSQSQIPTIKSSQSSGLARRKRILKTQSQKATP
LSQSTQNLSVLPDSMTPAFTLMQPPSSQISFVNDSQPRNSQKAKKKKKRIRGFG

Sequence of entity 5 (R), FASTA

>6RQH_5 RNA polymerase I-specific transcription initiation factor RRN11 (chains R)
MFEVPITLTNRKFAQRRKLKYQYINYISRRFDRISKKSTTTDSLPTPENSAAENNDEEEG
QNSEAGTYRRSVLQQKKRRRERHWRSVVGEIYSTTESETDSQEEETEEGGEHDTGIDKED
SDEERKFWKKYEKPEKSFEIWRTVSSQNKQPINKQKMTYHNFKKIEKIPLRKMEIPLLHC
TKENKLYFQSISRGLEPLKTSTSEVRNYRTRHIVTLTDLLHLNVSRHNWSLAYKIFATLI
RIPGVQIKSLWGIGVEILDNLSNSSSGLDFLQWMCQIYSSKSRFVQNINYRSIVPPFQTG
SRTHTAKFAITYLWSSLINCQKSMEPSSNIIDKPFDTENDLLQELIDKISEWVLTPPFME
DAEVWFIYASCHLLKADTLSRQFVNDNKNNDLIGLDRDIKINQVIKHIHYVRTFLKICLD
KGGFAVPSRLIENQLKSFESRLYGEAQDIQERDVANVYDSIDNSSVENSFGDVYETNAEF
LDTQLMDLSPEDNGLDEMHYSDEDSSE

Sequence of entity 6 (M), FASTA

>6RQH_6 DNA-directed RNA polymerase I subunit RPA49 (chains M)
MSVKRSVSEIEIESVQDQPSVAVGSFFKGFRAPSDTTFDLYKKKKSEKDEFVLHGENERL
EYEGYTDSSSQASNQYVVGLFNPEKKSIQLYKAPVLVSKVVSKSSKNLRGPKIKSKSDTR
PSALRNALGEAFGTKKAKKAIADLERNRIDSDKLTDSAIDIVDSVRTASKDLPTRAQLDE
ITSNDRPTPLANIDATDVEQIYPIESIIPKKELQFIRVSSILKEADKEKKLELFPYQNNS
KYVAKKLDSLTQPSQMTKLQLLYYLSLLLGVYENRRVNNKTKLLERLNSPPEILVDGILS
RFTVIKPGQFGRSKDRSYFIDPQNEDKILCYILAIIMHLDNFIVEITPLAHELNLKPSKV
VSLFRVLGAIVKGATVAQAEAFGIPKSTAASYKIATMKVPFKLPEMTRRGRGPRR

Sequence of entity 7 (A), FASTA

>6RQH_7 DNA-directed RNA polymerase I subunit RPA190 (chains A)
MDISKPVGSEITSVDFGILTAKEIRNLSAKQITNPTVLDNLGHPVSGGLYDLALGAFLRN
LCSTCGLDEKFCPGHQGHIELPVPCYNPLFFNQLYIYLRASCLFCHHFRLKSVEVHRYAC
KLRLLQYGLIDESYKLDEITLGSLNSSMYTDDEAIEDNEDEMDGEGSKQSKDISSTLLNE
LKSKRSEYVDMAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLSRGKCDNCGMFS
PKFRKDGFTKIFETALNEKQITNNRVKGFIRQDMIKKQKQAKKLDGSNEASANDEESFDV
GRNPTTRPKTGSTYILSTEVKNILDTVFRKEQCVLQYVFHSRPNLSRKLVKADSFFMDVL
VVPPTRFRLPSKLGEEVHENSQNQLLSKVLTTSLLIRDLNDDLSKLQKDKVSLEDRRVIF
SRLMNAFVTIQNDVNAFIDSTKAQGRTSGKVPIPGVKQALEKKEGLFRKHMMGKRVNYAA
RSVISPDPNIETNEIGVPPVFAVKLTYPEPVTAYNIAELRQAVINGPDKWPGATQIQNED
GSLVSLIGMSVEQRKALANQLLTPSSNVSTHTLNKKVYRHIKNRDVVLMNRQPTLHKASM
MGHKVRVLPNEKTLRLHYANTGAYNADFDGDEMNMHFPQNENARAEALNLANTDSQYLTP
TSGSPVRGLIQDHISAGVWLTSKDSFFTREQYQQYIYGCIRPEDGHTTRSKIVTLPPTIF
KPYPLWTGKQIITTVLLNVTPPDMPGINLISKNKIKNEYWGKGSLENEVLFKDGALLCGI
LDKSQYGASKYGIVHSLHEVYGPEVAAKVLSVLGRLFTNYITATAFTCGMDDLRLTAEGN
KWRTDILKTSVDTGREAAAEVTNLDKDTPADDPELLKRLQEILRDNNKSGILDAVTSSKV
NAITSQVVSKCVPDGTMKKFPCNSMQAMALSGAKGSNVNVSQIMCLLGQQALEGRRVPVM
VSGKTLPSFKPYETDAMAGGYVKGRFYSGIKPQEYYFHCMAGREGLIDTAVKTSRSGYLQ
RCLTKQLEGVHVSYDNSIRDADGTLVQFMYGGDAIDITKESHMTQFEFCLDNYYALLKKY
NPSALIEHLDVESALKYSKKTLKYRKKHSKEPHYKQSVKYDPVLAKYNPAKYLGSVSENF
QDKLESFLDKNSKLFKSSDGVNEKKFRALMQLKYMRSLINPGEAVGIIASQSVGEPSTQM
TLNTFHFAGHGAANVTLGIPRLREIVMTASAAIKTPQMTLPIWNDVSDEQADTFCKSISK
VLLSEVIDKVIVTETTGTSNTAGGNAARSYVIHMRFFDNNEYSEEYDVSKEELQNVISNQ
FIHLLEAAIVKEIKKQKRTTGPDIGVAVPRLQTDVANSSSNSKRLEEDNDEEQSHKKTKQ
AVSYDEPDEDEIETMREAEKSSDEEGIDSDKESDSDSEDEDVDMNEQINKSIVEANNNMN
KVQRDRQSAIISHHRFITKYNFDDESGKWCEFKLELAADTEKLLMVNIVEEICRKSIIRQ
IPHIDRCVHPEPENGKRVLVTEGVNFQAMWDQEAFIDVDGITSNDVAAVLKTYGVEAARN
TIVNEINNVFSRYAISVSFRHLDLIADMMTRQGTYLAFNRQGMETSTSSFMKMSYETTCQ
FLTKAVLDNEREQLDSPSARIVVGKLNNVGTGSFDVLAKVPNAA

Sequence of entity 8 (B), FASTA

>6RQH_8 DNA-directed RNA polymerase I subunit RPA135 (chains B)
MSKVIKPPGQARTADFRTLERESRFINPPKDKSAFPLLQEAVQPHIGSFNALTEGPDGGL
LNLGVKDIGEKVIFDGKPLNSEDEISNSGYLGNKLSVSVEQVSIAKPMSNDGVSSAVERK
VYPSESRQRLTSYRGKLLLKLKWSVNNGEENLFEVRDCGGLPVMLQSNRCHLNKMSPYEL
VQHKEESDEIGGYFIVNGIEKLIRMLIVQRRNHPMAIIRPSFANRGASYSHYGIQIRSVR
PDQTSQTNVLHYLNDGQVTFRFSWRKNEYLVPVVMILKALCHTSDREIFDGIIGNDVKDS
FLTDRLELLLRGFKKRYPHLQNRTQVLQYLGDKFRVVFQASPDQSDLEVGQEVLDRIVLV
HLGKDGSQDKFRMLLFMIRKLYSLVAGECSPDNPDATQHQEVLLGGFLYGMILKEKIDEY
LQNIIAQVRMDINRGMAINFKDKRYMSRVLMRVNENIGSKMQYFLSTGNLVSQSGLDLQQ
VSGYTVVAEKINFYRFISHFRMVHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPDGSPCG
LLNHFAHKCRISTQQSDVSRIPSILYSLGVAPASHTFAAGPSLCCVQIDGKIIGWVSHEQ
GKIIADTLRYWKVEGKTPGLPIDLEIGYVPPSTRGQYPGLYLFGGHSRMLRPVRYLPLDK
EDIVGPFEQVYMNIAVTPQEIQNNVHTHVEFTPTNILSILANLTPFSDFNQSPRNMYQCQ
MGKQTMGTPGVALCHRSDNKLYRLQTGQTPIVKANLYDDYGMDNFPNGFNAVVAVISYTG
YDMDDAMIINKSADERGFGYGTMYKTEKVDLALNRNRGDPITQHFGFGNDEWPKEWLEKL
DEDGLPYIGTYVEEGDPICAYFDDTLNKTKIKTYHSSEPAYIEEVNLIGDESNKFQELQT
VSIKYRIRRTPQIGDKFSSRHGQKGVCSRKWPTIDMPFSETGIQPDIIINPHAFPSRMTI
GMFVESLAGKAGALHGIAQDSTPWIFNEDDTPADYFGEQLAKAGYNYHGNEPMYSGATGE
ELRADIYVGVVYYQRLRHMVNDKFQVRSTGPVNSLTMQPVKGRKRHGGIRVGEMERDALI
GHGTSFLLQDRLLNSSDYTQASVCRECGSILTTQQSVPRIGSISTVCCRRCSMRFEDAKK
LLTKSEDGEKIFIDDSQIWEDGQGNKFVGGNETTTVAIPFVLKYLDSELSAMGIRLRYNV
EPK

Sequence of entity 9 (C), FASTA

>6RQH_9 DNA-directed RNA polymerases I and III subunit RPAC1 (chains C)
MSNIVGIEYNRVTNTTSTDFPGFSKDAENEWNVEKFKKDFEVNISSLDAREANFDLINID
TSIANAFRRIMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLVPLKVDPDMLTWVDSNL
PDDEKFTDENTIVLSLNVKCTRNPDAPKGSTDPKELYNNAHVYARDLKFEPQGRQSTTFA
DCPVVPADPDILLAKLRPGQEISLKAHCILGIGGDHAKFSPVSTASYRLLPQINILQPIK
GESARRFQKCFPPGVIGIDEGSDEAYVKDARKDTVSREVLRYEEFADKVKLGRVRNHFIF
NVESAGAMTPEEIFFKSVRILKNKAEYLKNCPITQ

Sequence of entity 10 (D), FASTA

>6RQH_10 DNA-directed RNA polymerase I subunit RPA14 (chains D)
MMKGSRRTGNNTATTLNTPVVIHATQLPQHVSTDEVLQFLESFIDEKENIIDSTTMNTIS
GNAADADAAAVANTSLNIDTNLSSSISQLKRIQRDFKGLPPAQDFSAAPIQVSTTEKKET
SIGVSATGGKKTTFADE

Sequence of entity 11 (E), FASTA

>6RQH_11 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSF
QANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSA
MKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQR
ADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM

Sequence of entity 12 (F), FASTA

>6RQH_12 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQ
HEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRI
AMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL

Primary citation

Molecular insight into RNA polymerase I promoter recognition and promoter melting. Sadian, Y., Baudin, F., Tafur, L. et al. Nat Commun (2019) 10:5543-5543. DOI 10.1038/s41467-019-13510-w · PubMed

Other PDB entries of the same protein (UniProt P40992 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6RUI 2.7 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 2
6RQL 2.9 Å, RNA Polymerase I Closed Conformation 2 (CC2)
6RWE 3.0 Å, RNA Polymerase I Open Complex conformation 2
6RRD 3.1 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 1
5O7X 3.2 Å, Crystal structure of S. Cerevisiae core factor at 3.2A resolution
5N61 3.4 Å, RNA polymerase I initially transcribing complex
6RUO 3.5 Å, RNA Polymerase I Open Complex conformation 1
6TPS 3.54 Å, early intermediate RNA Polymerase I Pre-initiation complex - eiPIC
5W5Y 3.8 Å, RNA polymerase I Initial Transcribing Complex
5W66 3.9 Å, RNA polymerase I Initial Transcribing Complex State 3
5W64 4.2 Å, RNA Polymerase I Initial Transcribing Complex State 1
5W65 4.3 Å, RNA polymerase I Initial Transcribing Complex State 2

Browse structure collections

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