6RQL: RNA Polymerase I Closed Conformation 2

RNA Polymerase I Closed Conformation 2 (CC2). Determined by electron microscopy at 2.9 Å resolution. Released 11 Dec 2019.

Method: Electron microscopy
Resolution: 2.9 Å
Organisms: synthetic construct, Saccharomyces cerevisiae
Chains: 20
Atoms: 51,626
Mol. weight: 927.83 kDa
Released: 11 Dec 2019

Explore 6RQL in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6RQL contains 283 α-helices and 312 β-strands across 18 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 81 helices, 69 β-strands

Element	Residues	Length	Sheet
β-strand	11-18	8	22
α-helix	24-27	4
β-strand	38	1	23
β-strand	44	1	23
α-helix	45	1
α-helix	60-62	3
β-strand	77-86	10	24
α-helix	87	1
α-helix	95-99	5
β-strand	101-102	2	25
β-strand	107-108	2	25
α-helix	112-125	14
α-helix	131-133	3
α-helix	175-198	24
α-helix	210-226	17
α-helix	240-242	3
β-strand	243-245	3	26
β-strand	251-253	3	26
α-helix	254-256	3
α-helix	261-267	7
β-strand	313-315	3	26
α-helix	317-330	14
α-helix	332-335	4
α-helix	343-344	2
α-helix	352-354	3
β-strand	356-362	7	24
α-helix	365-368	4
α-helix	369-371	3
β-strand	373	1	27
β-strand	376	1	27
β-strand	377	1	3
α-helix	381-403	23
α-helix	418-438	21
β-strand	475-476	2	28
β-strand	479-486	8	29
β-strand	494-497	4	29
α-helix	499-502	4
β-strand	506-510	5	2
α-helix	516-525	10
β-strand	533-537	5	2
β-strand	543-545	3	2
α-helix	551-558	8
α-helix	563-565	3
β-strand	576-580	5	2
β-strand	586-591	6	29
α-helix	597-599	3
β-strand	600-607	8	29
β-strand	614-616	3	29
α-helix	618-620	3
β-strand	632-636	5	29
α-helix	641-647	7
β-strand	652	1	29
β-strand	658	1	30
β-strand	665	1	30
α-helix	674-680	7
β-strand	686-687	2	31
α-helix	689-699	11
β-strand	719	1	32
β-strand	725	1	32
β-strand	726-727	2	31
α-helix	729-739	11
α-helix	745-747	3
β-strand	749-752	4	33
α-helix	757-759	3
β-strand	768-771	4	33
β-strand	776-778	3	33
α-helix	783-786	4
α-helix	793-800	8
α-helix	803-823	21
β-strand	826-827	2	34
α-helix	834	1
β-strand	835	1	35
α-helix	836	1
α-helix	837-848	12
α-helix	854-861	8
α-helix	873-881	9
α-helix	892-911	20
β-strand	916	1	35
α-helix	924-930	7
α-helix	937-944	8
β-strand	948-949	2	36
β-strand	981-982	2	36
β-strand	985	1	37
β-strand	989	1	37
α-helix	992-1001	10
α-helix	1010-1012	3
α-helix	1017-1026	10
β-strand	1031-1032	2	38
β-strand	1038-1039	2	38
β-strand	1045-1047	3	38
β-strand	1055	1	39
α-helix	1057-1059	3
α-helix	1066-1071	6
α-helix	1073-1077	5
α-helix	1086-1088	3
β-strand	1090	1	40
α-helix	1092-1107	16
α-helix	1113-1115	3
α-helix	1123-1125	3
β-strand	1132	1	40
α-helix	1138-1149	12
α-helix	1164-1175	12
β-strand	1178	1	39
α-helix	1179-1180	2
α-helix	1185-1194	10
α-helix	1196-1198	3
α-helix	1215-1217	3
α-helix	1218-1225	8
β-strand	1227	1	41
β-strand	1238-1241	4	42
β-strand	1242	1	43
α-helix	1248-1258	11
β-strand	1261-1262	2	44
α-helix	1263-1266	4
β-strand	1267-1275	9	45
β-strand	1289-1296	8	45
α-helix	1299-1305	7
α-helix	1310-1316	7
α-helix	1317-1321	5
α-helix	1322-1338	17
α-helix	1346-1347	2
β-strand	1348	1	46
α-helix	1364-1366	3
β-strand	1368	1	47
α-helix	1390-1396	7
α-helix	1441-1453	13
β-strand	1460-1462	3	45
β-strand	1469-1472	4	45
β-strand	1475	1	45
α-helix	1485-1493	9
β-strand	1497-1499	3	44
β-strand	1504-1508	5	42
β-strand	1513	1	48
β-strand	1516	1	48
β-strand	1518-1523	6	42
α-helix	1526-1529	4
β-strand	1536	1	43
β-strand	1542-1543	2	42
α-helix	1546-1553	8
α-helix	1555-1572	18
α-helix	1579-1589	11
β-strand	1598	1	41
α-helix	1600-1603	4
α-helix	1609-1615	7
α-helix	1618-1627	10
α-helix	1630	1
β-strand	1631-1632	2	22
α-helix	1637-1643	7
α-helix	1645-1647	3
β-strand	1654-1659	6	49

Chain B: 53 helices, 81 β-strands

Element	Residues	Length	Sheet
β-strand	14	1	50
α-helix	20-26	7
α-helix	43-50	8
α-helix	56-58	3
α-helix	59-64	6
β-strand	71-72	2	51
α-helix	85-88	4
β-strand	95-104	10	51
β-strand	109	1	52
β-strand	119	1	52
α-helix	123-128	6
β-strand	134-145	12	51
β-strand	150	1	51
β-strand	155-162	8	51
α-helix	177-182	6
β-strand	194-196	3	53
β-strand	199-203	5	53
α-helix	204-205	2
β-strand	206-209	4	54
α-helix	210	1
β-strand	215	1	55
β-strand	218	1	56
α-helix	220-222	3
β-strand	229-239	11	55
β-strand	245-253	9	55
β-strand	259-262	4	55
β-strand	268	1	46
β-strand	269-272	4	55
α-helix	273-280	8
α-helix	285-292	8
α-helix	302-305	4
α-helix	311-316	6
α-helix	323-333	11
α-helix	346-356	11
α-helix	367-385	19
α-helix	390-393	4
β-strand	400-403	4	54
α-helix	405-409	5
α-helix	412-429	18
α-helix	443-450	8
α-helix	457-467	11
β-strand	485-487	3	53
α-helix	493-497	5
β-strand	502	1	57
α-helix	507-510	4
α-helix	522-524	3
β-strand	528	1	58
β-strand	536	1	47
β-strand	544	1	57
β-strand	545	1	58
β-strand	550-551	2	59
α-helix	552	1
α-helix	561-567	7
α-helix	570	1
β-strand	571-572	2	60
β-strand	584-588	5	60
β-strand	591-596	6	60
α-helix	598-613	16
β-strand	625-629	5	60
α-helix	637-638	2
β-strand	639-643	5	60
β-strand	649-650	2	59
β-strand	651-655	5	61
β-strand	661-664	4	61
α-helix	669-671	3
β-strand	674-675	2	61
α-helix	678-680	3
β-strand	688-689	2	61
α-helix	693-696	4
α-helix	712-721	10
β-strand	725	1	62
α-helix	733-735	3
β-strand	740-744	5	63
β-strand	748	1	64
β-strand	752-753	2	65
α-helix	756-759	4
α-helix	762-764	3
β-strand	769-775	7	66
β-strand	776-777	2	34
β-strand	786-790	5	66
α-helix	791-795	5
β-strand	801-810	10	63
α-helix	820-821	2
β-strand	823-825	3	67
β-strand	840	1	68
β-strand	846	1	68
α-helix	847	1
β-strand	851-852	2	63
β-strand	857-863	7	67
β-strand	868-873	6	67
β-strand	880-888	9	63
α-helix	896-898	3
β-strand	900-909	10	63
β-strand	916-919	4	66
β-strand	925-931	7	66
β-strand	939	1	69
β-strand	947-949	3	66
α-helix	953-957	5
α-helix	961-974	14
β-strand	978	1	50
β-strand	979-980	2	65
β-strand	987	1	70
β-strand	990	1	70
α-helix	992-1002	11
β-strand	1010-1011	2	66
β-strand	1013	1	69
β-strand	1014	1	71
β-strand	1021	1	71
α-helix	1022	1
β-strand	1026-1035	10	66
β-strand	1036	1	62
α-helix	1040-1042	3
β-strand	1045-1047	3	29
β-strand	1052	1	72
α-helix	1058	1
β-strand	1059	1	72
α-helix	1060-1061	2
β-strand	1062	1	73
β-strand	1067	1	73
β-strand	1069-1070	2	28
α-helix	1073-1081	9
α-helix	1085-1089	5
α-helix	1090-1094	5
β-strand	1099-1104	6	74
β-strand	1115	1	75
β-strand	1117	1	76
α-helix	1123-1124	2
β-strand	1126	1	75
β-strand	1132-1134	3	76
β-strand	1158-1160	3	76
β-strand	1166-1169	4	76
β-strand	1173-1178	6	74
α-helix	1180-1188	9
β-strand	1194-1200	7	22

Chain C: 13 helices, 16 β-strands

Element	Residues	Length	Sheet
α-helix	33-38	6
β-strand	41-47	7	77
β-strand	52-57	6	77
α-helix	61-72	12
β-strand	76-88	13	78
α-helix	94-102	9
α-helix	105	1
β-strand	106	1	79
α-helix	115-117	3
α-helix	122-125	4
β-strand	132-139	8	78
β-strand	141-142	2	80
α-helix	153-156	4
β-strand	157-158	2	80
β-strand	161-163	3	81
α-helix	164-166	3
β-strand	168-170	3	78
β-strand	186	1	79
β-strand	192-195	4	81
β-strand	201-212	12	78
α-helix	217-219	3
β-strand	225-235	11	77
α-helix	242-244	3
β-strand	256-257	2	82
β-strand	266-267	2	82
α-helix	270-272	3
α-helix	279-281	3
β-strand	289-302	14	77
α-helix	312-329	18

Chain D: 3 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	2-11	10
β-strand	22-24	3	49
β-strand	29-30	2	49
α-helix	33-46	14
α-helix	83-95	13

Chain E: 13 helices, 14 β-strands

Element	Residues	Length	Sheet
α-helix	5-25	21
β-strand	28	1	83
α-helix	32-35	4
α-helix	39-46	8
β-strand	47	1	84
β-strand	53	1	84
β-strand	60-62	3	85
β-strand	64	1	83
α-helix	66-71	6
β-strand	78-82	5	85
β-strand	87-88	2	86
α-helix	93-103	11
β-strand	107-112	6	85
β-strand	115-116	2	86
α-helix	120-123	4
β-strand	131-136	6	85
α-helix	137-140	4
α-helix	144-146	3
β-strand	152-155	4	87
α-helix	156-157	2
α-helix	158-167	10
α-helix	172-174	3
β-strand	177-178	2	87
α-helix	185-188	4
α-helix	190-191	2
β-strand	195-202	8	87
β-strand	206-214	9	87

Chain F: 4 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	56-68	13
β-strand	73	1	49
β-strand	84-85	2	88
α-helix	88-101	14
α-helix	105-107	3
α-helix	117-126	10
β-strand	132-137	6	49
β-strand	143-147	5	49
β-strand	152-153	2	88

Chain G: 13 helices, 16 β-strands

Element	Residues	Length	Sheet
α-helix	14-20	7
α-helix	25-27	3
β-strand	28	1	89
α-helix	34	1
β-strand	35	1	89
α-helix	36	1
β-strand	38-49	12	49
α-helix	51-53	3
α-helix	57-61	5
α-helix	62-66	5
β-strand	73-74	2	49
β-strand	79-89	11	49
α-helix	90-91	2
β-strand	104-107	4	49
α-helix	108	1
β-strand	114-125	12	49
β-strand	131-140	10	90
β-strand	145-148	4	90
α-helix	149-151	3
β-strand	154-156	3	90
α-helix	159-161	3
β-strand	168	1	91
β-strand	217	1	91
β-strand	218	1	92
α-helix	223	1
β-strand	224	1	92
α-helix	225	1
β-strand	228-236	9	90
β-strand	244-248	5	90

Chain H: 2 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	4-7	4	32
β-strand	10-16	7	93
β-strand	23-30	8	93
β-strand	37-43	7	93
β-strand	54-55	2	93
β-strand	56-60	5	32
α-helix	89-91	3
β-strand	95-99	5	32
β-strand	100-103	4	93
β-strand	106	1	93
β-strand	112-118	7	93
β-strand	121-127	7	93
α-helix	130-132	3
β-strand	140-145	6	32

10 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Template strand	T	DNA	70	synthetic construct
Nontemplate strand	U	DNA	70	synthetic construct
RNA polymerase I-specific transcription initiation factor RRN7	Q	protein	514	Saccharomyces cerevisiae	P40992 (AlphaFold model)
RNA polymerase I-specific transcription initiation factor RRN6	S	protein	894	Saccharomyces cerevisiae	P32786 (AlphaFold model)
RNA polymerase I-specific transcription initiation factor RRN11	R	protein	507	Saccharomyces cerevisiae	Q04712 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA49	M	protein	415	Saccharomyces cerevisiae	Q01080 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA190	A	protein	1664	Saccharomyces cerevisiae	P10964
DNA-directed RNA polymerase I subunit RPA135	B	protein	1203	Saccharomyces cerevisiae	P22138
DNA-directed RNA polymerases I and III subunit RPAC1	C	protein	335	Saccharomyces cerevisiae	P07703
DNA-directed RNA polymerase I subunit RPA14	D	protein	137	Saccharomyces cerevisiae	P50106
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	215	Saccharomyces cerevisiae	P20434
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	155	Saccharomyces cerevisiae	P20435

8 more molecules are not listed.

Sequence of entity 1 (T), FASTA

>6RQL_1 Template strand (chains T)
GTCTTCAACTGCTTTCGCATGAAGTACCTCCCAACTACTTTTCCTCACACTTGTACTCCA
TGACTAAACC

Sequence of entity 2 (U), FASTA

>6RQL_2 Nontemplate strand (chains U)
GGTTTAGTCATGGAGTACAAGTGTGAGGAAAAGTAGTTGGGAGGTACTTCATGCGAAAGC
AGTTGAAGAC

Sequence of entity 3 (Q), FASTA

>6RQL_3 RNA polymerase I-specific transcription initiation factor RRN7 (chains Q)
MSTFIRGPICGTDNCPSRLWRIIDGRRTCQYGHVMEGDVEFNDDEDDLNGLGAGVITRRL
NLTTNATGSFQSSQLTNSQLLQQQQRQSHKKFKKLIGHEAKLLFLKSFQFILKRQIRWLI
TEMRFPKEFEHVAKIIWLKILKTINDQPQEELKLQLHMTSTISILYLASTHLSLPVYTCD
YIKWICTAKMPYFQASEILPKSWRIQLPNYYVSILEGSISPFNGQLYNKIALTCGMIHFK
EFFNSEISCQGLLLKLVMQCALPPEFYFYTKQVIEFEETDIRNLTLWERTDERHTGRVSN
HAELRVLSYFMLTINWMLSFDRDRQYPLKWILSLTESLTQRTTTSESIGRNIVKVVYPDK
PTSSDYFQWSEEETLEFLKWMEKQFLPTQTKSLHNENGSMEMTIDQKIARRKLYKIFPLD
REANHDGEFNDSTHQLTFIEDLQERYAKQTPFFESNKIRDSLNYQEANPPARKEAIGRLL
THIASQLLVDFAISKEQLKDCISRIKNACLHRMN

Sequence of entity 4 (S), FASTA

>6RQL_4 RNA polymerase I-specific transcription initiation factor RRN6 (chains S)
MSEGQIPSSDVLGSQLGVGVQGASLYCPQENYTTKKQEKPQWLRPVDDTLAEDALDLHIV
VKSLLCDTAIRYISDDKVLQESDADDDLITSDIDEDTDNQGDTSIVVNPVIPVVPKDVHF
FKKVDVGNDSMFGVNCDTPVSFQDYIPSDLLRNLDDTLQESTNSSRPMQDAFFWDPTVAN
RLDSQYIQTASDLRNYRDGTEIIAYASGKTGSVLNIAVLTRQNTLHLNRHNNVTSIELHS
PIKSIKIPGASESIGRRSNLVGIITENSFQIFRIESVHSRSCDVMVSSSEPLYFVEIDDL
QVVDFAFNPWDLQQFAIIDIKGNWSIGRIPKNFNNNNKRKLQLIDNLHGTIFDPEELSSW
KRIEWFSHFQKILVFDRSKMIEIDFMNNWQTEVVQAKAWSNIRDYKRIDDKNGILLTSRE
IIIVGASESNDPVRRISWKHDLDPDDTTLRITVQKVKKPDHILLVAFVYSMRHKRIYMHV
FSHRKANLFQSLGCSTVLEIPGGTPTGIETILTLDHIDDESRREEDADENFELVVDFLVK
LRNSSEVYYYALSNTQNSEPNKQETPIIVDHPEWASLFNNADEREKESIGALVSQIKLKE
RERISRVQNLIEHENSHDEDKYLQDLGYRLSIATNELLESWQKTKDESILSGSLSHSKLK
NLLENSDSFASIPEFSSLLDQFFQYYQDQDVTFIGFEKLLHLFLHEDVPGLDIFYNKLLQ
CWVLVSPQAELLTKEIVKDIIWSLARLEKPSLFEPIQNEISRSLSGPYQDIISSWDMDDI
NEEDESNEFNFDSQFSAPFNGRPPFNLNSQSQIPTIKSSQSSGLARRKRILKTQSQKATP
LSQSTQNLSVLPDSMTPAFTLMQPPSSQISFVNDSQPRNSQKAKKKKKRIRGFG

Sequence of entity 5 (R), FASTA

>6RQL_5 RNA polymerase I-specific transcription initiation factor RRN11 (chains R)
MFEVPITLTNRKFAQRRKLKYQYINYISRRFDRISKKSTTTDSLPTPENSAAENNDEEEG
QNSEAGTYRRSVLQQKKRRRERHWRSVVGEIYSTTESETDSQEEETEEGGEHDTGIDKED
SDEERKFWKKYEKPEKSFEIWRTVSSQNKQPINKQKMTYHNFKKIEKIPLRKMEIPLLHC
TKENKLYFQSISRGLEPLKTSTSEVRNYRTRHIVTLTDLLHLNVSRHNWSLAYKIFATLI
RIPGVQIKSLWGIGVEILDNLSNSSSGLDFLQWMCQIYSSKSRFVQNINYRSIVPPFQTG
SRTHTAKFAITYLWSSLINCQKSMEPSSNIIDKPFDTENDLLQELIDKISEWVLTPPFME
DAEVWFIYASCHLLKADTLSRQFVNDNKNNDLIGLDRDIKINQVIKHIHYVRTFLKICLD
KGGFAVPSRLIENQLKSFESRLYGEAQDIQERDVANVYDSIDNSSVENSFGDVYETNAEF
LDTQLMDLSPEDNGLDEMHYSDEDSSE

Sequence of entity 6 (M), FASTA

>6RQL_6 DNA-directed RNA polymerase I subunit RPA49 (chains M)
MSVKRSVSEIEIESVQDQPSVAVGSFFKGFRAPSDTTFDLYKKKKSEKDEFVLHGENERL
EYEGYTDSSSQASNQYVVGLFNPEKKSIQLYKAPVLVSKVVSKSSKNLRGPKIKSKSDTR
PSALRNALGEAFGTKKAKKAIADLERNRIDSDKLTDSAIDIVDSVRTASKDLPTRAQLDE
ITSNDRPTPLANIDATDVEQIYPIESIIPKKELQFIRVSSILKEADKEKKLELFPYQNNS
KYVAKKLDSLTQPSQMTKLQLLYYLSLLLGVYENRRVNNKTKLLERLNSPPEILVDGILS
RFTVIKPGQFGRSKDRSYFIDPQNEDKILCYILAIIMHLDNFIVEITPLAHELNLKPSKV
VSLFRVLGAIVKGATVAQAEAFGIPKSTAASYKIATMKVPFKLPEMTRRGRGPRR

Sequence of entity 7 (A), FASTA

>6RQL_7 DNA-directed RNA polymerase I subunit RPA190 (chains A)
MDISKPVGSEITSVDFGILTAKEIRNLSAKQITNPTVLDNLGHPVSGGLYDLALGAFLRN
LCSTCGLDEKFCPGHQGHIELPVPCYNPLFFNQLYIYLRASCLFCHHFRLKSVEVHRYAC
KLRLLQYGLIDESYKLDEITLGSLNSSMYTDDEAIEDNEDEMDGEGSKQSKDISSTLLNE
LKSKRSEYVDMAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLSRGKCDNCGMFS
PKFRKDGFTKIFETALNEKQITNNRVKGFIRQDMIKKQKQAKKLDGSNEASANDEESFDV
GRNPTTRPKTGSTYILSTEVKNILDTVFRKEQCVLQYVFHSRPNLSRKLVKADSFFMDVL
VVPPTRFRLPSKLGEEVHENSQNQLLSKVLTTSLLIRDLNDDLSKLQKDKVSLEDRRVIF
SRLMNAFVTIQNDVNAFIDSTKAQGRTSGKVPIPGVKQALEKKEGLFRKHMMGKRVNYAA
RSVISPDPNIETNEIGVPPVFAVKLTYPEPVTAYNIAELRQAVINGPDKWPGATQIQNED
GSLVSLIGMSVEQRKALANQLLTPSSNVSTHTLNKKVYRHIKNRDVVLMNRQPTLHKASM
MGHKVRVLPNEKTLRLHYANTGAYNADFDGDEMNMHFPQNENARAEALNLANTDSQYLTP
TSGSPVRGLIQDHISAGVWLTSKDSFFTREQYQQYIYGCIRPEDGHTTRSKIVTLPPTIF
KPYPLWTGKQIITTVLLNVTPPDMPGINLISKNKIKNEYWGKGSLENEVLFKDGALLCGI
LDKSQYGASKYGIVHSLHEVYGPEVAAKVLSVLGRLFTNYITATAFTCGMDDLRLTAEGN
KWRTDILKTSVDTGREAAAEVTNLDKDTPADDPELLKRLQEILRDNNKSGILDAVTSSKV
NAITSQVVSKCVPDGTMKKFPCNSMQAMALSGAKGSNVNVSQIMCLLGQQALEGRRVPVM
VSGKTLPSFKPYETDAMAGGYVKGRFYSGIKPQEYYFHCMAGREGLIDTAVKTSRSGYLQ
RCLTKQLEGVHVSYDNSIRDADGTLVQFMYGGDAIDITKESHMTQFEFCLDNYYALLKKY
NPSALIEHLDVESALKYSKKTLKYRKKHSKEPHYKQSVKYDPVLAKYNPAKYLGSVSENF
QDKLESFLDKNSKLFKSSDGVNEKKFRALMQLKYMRSLINPGEAVGIIASQSVGEPSTQM
TLNTFHFAGHGAANVTLGIPRLREIVMTASAAIKTPQMTLPIWNDVSDEQADTFCKSISK
VLLSEVIDKVIVTETTGTSNTAGGNAARSYVIHMRFFDNNEYSEEYDVSKEELQNVISNQ
FIHLLEAAIVKEIKKQKRTTGPDIGVAVPRLQTDVANSSSNSKRLEEDNDEEQSHKKTKQ
AVSYDEPDEDEIETMREAEKSSDEEGIDSDKESDSDSEDEDVDMNEQINKSIVEANNNMN
KVQRDRQSAIISHHRFITKYNFDDESGKWCEFKLELAADTEKLLMVNIVEEICRKSIIRQ
IPHIDRCVHPEPENGKRVLVTEGVNFQAMWDQEAFIDVDGITSNDVAAVLKTYGVEAARN
TIVNEINNVFSRYAISVSFRHLDLIADMMTRQGTYLAFNRQGMETSTSSFMKMSYETTCQ
FLTKAVLDNEREQLDSPSARIVVGKLNNVGTGSFDVLAKVPNAA

Sequence of entity 8 (B), FASTA

>6RQL_8 DNA-directed RNA polymerase I subunit RPA135 (chains B)
MSKVIKPPGQARTADFRTLERESRFINPPKDKSAFPLLQEAVQPHIGSFNALTEGPDGGL
LNLGVKDIGEKVIFDGKPLNSEDEISNSGYLGNKLSVSVEQVSIAKPMSNDGVSSAVERK
VYPSESRQRLTSYRGKLLLKLKWSVNNGEENLFEVRDCGGLPVMLQSNRCHLNKMSPYEL
VQHKEESDEIGGYFIVNGIEKLIRMLIVQRRNHPMAIIRPSFANRGASYSHYGIQIRSVR
PDQTSQTNVLHYLNDGQVTFRFSWRKNEYLVPVVMILKALCHTSDREIFDGIIGNDVKDS
FLTDRLELLLRGFKKRYPHLQNRTQVLQYLGDKFRVVFQASPDQSDLEVGQEVLDRIVLV
HLGKDGSQDKFRMLLFMIRKLYSLVAGECSPDNPDATQHQEVLLGGFLYGMILKEKIDEY
LQNIIAQVRMDINRGMAINFKDKRYMSRVLMRVNENIGSKMQYFLSTGNLVSQSGLDLQQ
VSGYTVVAEKINFYRFISHFRMVHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPDGSPCG
LLNHFAHKCRISTQQSDVSRIPSILYSLGVAPASHTFAAGPSLCCVQIDGKIIGWVSHEQ
GKIIADTLRYWKVEGKTPGLPIDLEIGYVPPSTRGQYPGLYLFGGHSRMLRPVRYLPLDK
EDIVGPFEQVYMNIAVTPQEIQNNVHTHVEFTPTNILSILANLTPFSDFNQSPRNMYQCQ
MGKQTMGTPGVALCHRSDNKLYRLQTGQTPIVKANLYDDYGMDNFPNGFNAVVAVISYTG
YDMDDAMIINKSADERGFGYGTMYKTEKVDLALNRNRGDPITQHFGFGNDEWPKEWLEKL
DEDGLPYIGTYVEEGDPICAYFDDTLNKTKIKTYHSSEPAYIEEVNLIGDESNKFQELQT
VSIKYRIRRTPQIGDKFSSRHGQKGVCSRKWPTIDMPFSETGIQPDIIINPHAFPSRMTI
GMFVESLAGKAGALHGIAQDSTPWIFNEDDTPADYFGEQLAKAGYNYHGNEPMYSGATGE
ELRADIYVGVVYYQRLRHMVNDKFQVRSTGPVNSLTMQPVKGRKRHGGIRVGEMERDALI
GHGTSFLLQDRLLNSSDYTQASVCRECGSILTTQQSVPRIGSISTVCCRRCSMRFEDAKK
LLTKSEDGEKIFIDDSQIWEDGQGNKFVGGNETTTVAIPFVLKYLDSELSAMGIRLRYNV
EPK

Sequence of entity 9 (C), FASTA

>6RQL_9 DNA-directed RNA polymerases I and III subunit RPAC1 (chains C)
MSNIVGIEYNRVTNTTSTDFPGFSKDAENEWNVEKFKKDFEVNISSLDAREANFDLINID
TSIANAFRRIMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLVPLKVDPDMLTWVDSNL
PDDEKFTDENTIVLSLNVKCTRNPDAPKGSTDPKELYNNAHVYARDLKFEPQGRQSTTFA
DCPVVPADPDILLAKLRPGQEISLKAHCILGIGGDHAKFSPVSTASYRLLPQINILQPIK
GESARRFQKCFPPGVIGIDEGSDEAYVKDARKDTVSREVLRYEEFADKVKLGRVRNHFIF
NVESAGAMTPEEIFFKSVRILKNKAEYLKNCPITQ

Sequence of entity 10 (D), FASTA

>6RQL_10 DNA-directed RNA polymerase I subunit RPA14 (chains D)
MMKGSRRTGNNTATTLNTPVVIHATQLPQHVSTDEVLQFLESFIDEKENIIDSTTMNTIS
GNAADADAAAVANTSLNIDTNLSSSISQLKRIQRDFKGLPPAQDFSAAPIQVSTTEKKET
SIGVSATGGKKTTFADE

Sequence of entity 11 (E), FASTA

>6RQL_11 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSF
QANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSA
MKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQR
ADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM

Sequence of entity 12 (F), FASTA

>6RQL_12 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQ
HEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRI
AMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL

Primary citation

Molecular insight into RNA polymerase I promoter recognition and promoter melting. Sadian, Y., Baudin, F., Tafur, L. et al. Nat Commun (2019) 10:5543-5543. DOI 10.1038/s41467-019-13510-w · PubMed

Other PDB entries of the same protein (UniProt P40992 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6RUI 2.7 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 2
6RWE 3.0 Å, RNA Polymerase I Open Complex conformation 2
6RRD 3.1 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 1
5O7X 3.2 Å, Crystal structure of S. Cerevisiae core factor at 3.2A resolution
5N61 3.4 Å, RNA polymerase I initially transcribing complex
6RUO 3.5 Å, RNA Polymerase I Open Complex conformation 1
6TPS 3.54 Å, early intermediate RNA Polymerase I Pre-initiation complex - eiPIC
6RQH 3.7 Å, RNA Polymerase I Closed Conformation 1 (CC1)
5W5Y 3.8 Å, RNA polymerase I Initial Transcribing Complex
5W66 3.9 Å, RNA polymerase I Initial Transcribing Complex State 3
5W64 4.2 Å, RNA Polymerase I Initial Transcribing Complex State 1
5W65 4.3 Å, RNA polymerase I Initial Transcribing Complex State 2

Browse structure collections

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