6WMD: Human Sun2-KASH4 complex

Human Sun2-KASH4 complex. Determined by X-ray diffraction at 1.5 Å resolution. Released 2 Dec 2020.

Method: X-ray diffraction
Resolution: 1.5 Å
Organism: Homo sapiens
Chains: 2
Atoms: 2,106
Mol. weight: 25.81 kDa
Ligands: MG
Released: 2 Dec 2020

Explore 6WMD in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6WMD contains 8 α-helices and 14 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 13 β-strands

Element	Residues	Length	Sheet
α-helix	525-540	16
α-helix	552-554	3
β-strand	557-558	2	1
α-helix	560-562	3
α-helix	564-567	4
β-strand	572-576	5	2
β-strand	579-583	5	2
α-helix	588-592	5
β-strand	602-605	4	3
β-strand	609-627	19	1
α-helix	631-633	3
α-helix	635-637	3
β-strand	643	1	4
β-strand	645-651	7	1
β-strand	660-666	7	1
β-strand	674-678	5	1
β-strand	687-694	8	1
β-strand	697	1	4
β-strand	703-706	4	3
β-strand	708-715	8	1

Chain B: 1 helix, 1 β-strand

Element	Residues	Length	Sheet
β-strand	394-397	4	2
α-helix	401-403	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
SUN domain-containing protein 2	A	protein	202	Homo sapiens	Q9UH99 (AlphaFold model)
Nesprin-4	B	protein	34	Homo sapiens	Q8N205 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>6WMD_1 SUN domain-containing protein 2 (chains A)
GPGGSGGVTEEQVHHIVKQALQRYSEDRIGLADYALESGGASVISTRCSETYETKTALLS
LFGIPLWYHSQSPRVILQPDVHPGNCWAFQGPQGFAVVRLSARIRPTAVTLEHVPKALSP
NSTISSAPKDFAIFGFDEDLQQEGTLLGKFTYDQDGEPIQTFHFQAPTMATYQVVELRIL
TNWGHPEYTCIYRFRVHGEPAH

Sequence of entity 2 (B), FASTA

>6WMD_2 Nesprin-4 (chains B)
GPGGSGSGGPCCSHARIPRTPYLVLSYVNGLPPV

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	2

Primary citation

Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes. Cruz, V.E., Esra Demircioglu, F., Schwartz, T.U. J Mol Biol (2020) 432:6028-6041. DOI 10.1016/j.jmb.2020.09.019 · PubMed

Other PDB entries of the same protein (UniProt Q9UH99 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6WME 1.53 Å, Human Sun2-KASH3 complex
6WMG 1.9 Å, Human Sun2 (500-717)
4DXT 2.22 Å, Human SUN2 (AA 522-717)
4DXR 2.32 Å, Human SUN2-KASH1 complex
3UNP 2.39 Å, Structure of human SUN2 SUN domain
6WMF 2.6 Å, Human Sun2-KASH5 complex
4DXS 2.71 Å, Human SUN2-KASH2 complex
4FI9 3.05 Å, Structure of human SUN-KASH complex

Browse structure collections

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