6YG9: Human serum albumin

Crystal structure of human serum albumin (HSA) in complex with gn-07. Determined by X-ray diffraction at 1.89 Å resolution. Released 13 Jan 2021.

Method: X-ray diffraction
Resolution: 1.89 Å
Organism: Homo sapiens
Chains: 1
Atoms: 5,303
Mol. weight: 68.76 kDa
Ligands: OQ5, MYR
Released: 13 Jan 2021

Explore 6YG9 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6YG9 contains 34 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 34 helices, 0 β-strands

Element	Residues	Length
α-helix	6-14	9
α-helix	16-30	15
α-helix	36-55	20
α-helix	66-76	11
α-helix	80-84	5
α-helix	85-92	8
α-helix	97-104	8
α-helix	120-129	10
α-helix	131-145	15
α-helix	151-168	18
α-helix	174-222	49
α-helix	228-247	20
α-helix	250-265	16
α-helix	268-270	3
α-helix	276-280	5
α-helix	283-291	9
α-helix	293-298	6
α-helix	306	1
α-helix	307-311	5
α-helix	315-320	6
α-helix	323-337	15
α-helix	343-360	18
α-helix	378-395	18
α-helix	399-414	16
α-helix	420-437	18
α-helix	445-466	22
α-helix	471-478	8
α-helix	484-489	6
α-helix	491-493	3
α-helix	499-502	4
α-helix	504-506	3
α-helix	511-514	4
α-helix	518-535	18
α-helix	572-578	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Serum albumin	A	protein	585	Homo sapiens	P02768 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>6YG9_1 Serum albumin (chains A)
DAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAE
NCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEV
DVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLP
KLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTK
VHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPA
DLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKC
CAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVST
PTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTES
LVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKAT
KEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGL

Ligands and cofactors

ID	Name	Formula	Copies
OQ5	20-[[(2~{S})-5-[2-[2-[2-[2-[2-[2-(diethylamino)-2-oxidanylidene-ethoxy]ethoxy]e…	C41 H76 N4 O12	1
MYR	Myristic acid	C14 H28 O2	6

Primary citation

Triantennary GalNAc Molecular Imaging Probes for Monitoring Hepatocyte Function in a Rat Model of Nonalcoholic Steatohepatitis. Mishra, A., Castaneda, T.R., Bader, E. et al. Adv Sci (Weinh) (2020) 7:2002997-2002997. DOI 10.1002/advs.202002997 · PubMed

Other PDB entries of the same protein (UniProt P02768 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9IK6 1.69 Å, Human Serum Albumin crystallized with T4, pH 6.5
1N5U 1.9 Å, X-ray study of human serum albumin complexed with heme
8RCO 1.9 Å, Structure of Human Serum Albumin in complex with Aristolochic Acid II at 1.9 A resolution
8RCP 1.9 Å, Structure of Human Serum Albumin in complex with Myristic Acid
8RGK 1.9 Å, Structure of Human Serum Albumin in complex with Aristolochic Acid at 1.9 A resolution
8RGL 1.9 Å, Structure of Human Serum Albumin in complex with Aristolochic Acid I at 1.9 A resolution…
9EOD 1.9 Å, Human serum albumin with adamantene carboxylic acid
9CSG 1.91 Å, Human Serum Albumin Bound to Cerastecin Compound 5e
6QIO 1.95 Å, Ternary complex of FcRn ectodomain, FcRn binding optimised human serum albumin and the…
9IK7 1.97 Å, Human Serum Albumin crystallized with T4, pH 7.5
7VR0 1.98 Å, Human Serum Albumin
7Y2D 2.0 Å, HSA-Cu agent complex

Browse structure collections

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