7CUN: Human Integrator-PP2A complex
The structure of human Integrator-PP2A complex. Determined by electron microscopy at 3.5 Å resolution. Released 25 Nov 2020.
- Method
- Electron microscopy
- Resolution
- 3.5 Å
- Organism
- Homo sapiens
- Chains
- 12
- Atoms
- 57,642
- Mol. weight
- 1210.28 kDa
- Ligands
- MN, ZN
- Released
- 25 Nov 2020
Explore 7CUN in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7CUN contains 439 α-helices and 118 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 46 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 1394-1402 | 9 | |
| α-helix | 1407-1424 | 18 | |
| α-helix | 1432-1444 | 13 | |
| α-helix | 1448-1455 | 8 | |
| α-helix | 1458-1474 | 17 | |
| α-helix | 1482-1499 | 18 | |
| α-helix | 1508-1518 | 11 | |
| α-helix | 1529-1536 | 8 | |
| α-helix | 1543-1557 | 15 | |
| α-helix | 1568-1571 | 4 | |
| α-helix | 1573-1577 | 5 | |
| α-helix | 1583-1591 | 9 | |
| α-helix | 1598-1608 | 11 | |
| α-helix | 1615-1624 | 10 | |
| α-helix | 1634-1641 | 8 | |
| α-helix | 1657-1667 | 11 | |
| α-helix | 1670-1680 | 11 | |
| α-helix | 1691-1702 | 12 | |
| α-helix | 1729-1742 | 14 | |
| α-helix | 1752-1769 | 18 | |
| α-helix | 1772-1779 | 8 | |
| α-helix | 1792-1796 | 5 | |
| α-helix | 1797-1801 | 5 | |
| α-helix | 1806-1814 | 9 | |
| α-helix | 1821-1823 | 3 | |
| α-helix | 1826-1842 | 17 | |
| α-helix | 1860-1863 | 4 | |
| α-helix | 1865-1872 | 8 | |
| α-helix | 1874-1885 | 12 | |
| α-helix | 1906-1916 | 11 | |
| α-helix | 1919-1922 | 4 | |
| α-helix | 1929-1944 | 16 | |
| α-helix | 1953-1968 | 16 | |
| α-helix | 1971-1980 | 10 | |
| α-helix | 1983-1985 | 3 | |
| α-helix | 2045-2047 | 3 | |
| α-helix | 2048-2056 | 9 | |
| α-helix | 2060-2073 | 14 | |
| α-helix | 2078-2083 | 6 | |
| α-helix | 2085-2092 | 8 | |
| α-helix | 2098-2113 | 16 | |
| α-helix | 2115-2121 | 7 | |
| α-helix | 2122-2129 | 8 | |
| α-helix | 2136-2151 | 16 | |
| α-helix | 2155-2168 | 14 | |
| α-helix | 2174-2184 | 11 | |
Chain B: 62 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 38-44 | 7 | |
| α-helix | 61-69 | 9 | |
| α-helix | 76-88 | 13 | |
| α-helix | 94-106 | 13 | |
| α-helix | 110-125 | 16 | |
| α-helix | 153-161 | 9 | |
| α-helix | 166-185 | 20 | |
| α-helix | 200-213 | 14 | |
| α-helix | 218-228 | 11 | |
| α-helix | 230-237 | 8 | |
| α-helix | 244-252 | 9 | |
| α-helix | 265-279 | 15 | |
| α-helix | 283-293 | 11 | |
| α-helix | 296-309 | 14 | |
| α-helix | 318-323 | 6 | |
| α-helix | 331-345 | 15 | |
| α-helix | 351-365 | 15 | |
| α-helix | 368-373 | 6 | |
| α-helix | 382-395 | 14 | |
| α-helix | 400-402 | 3 | |
| α-helix | 405-414 | 10 | |
| α-helix | 423-438 | 16 | |
| α-helix | 446-469 | 24 | |
| α-helix | 476-488 | 13 | |
| α-helix | 493-501 | 9 | |
| α-helix | 516-522 | 7 | |
| α-helix | 531-536 | 6 | |
| α-helix | 538-541 | 4 | |
| α-helix | 553-563 | 11 | |
| α-helix | 574-580 | 7 | |
| α-helix | 592-601 | 10 | |
| α-helix | 616-621 | 6 | |
| α-helix | 645-664 | 20 | |
| α-helix | 689-697 | 9 | |
| α-helix | 704-717 | 14 | |
| α-helix | 724-726 | 3 | |
| α-helix | 739-743 | 5 | |
| α-helix | 754-761 | 8 | |
| α-helix | 770-777 | 8 | |
| α-helix | 787-793 | 7 | |
| α-helix | 797-800 | 4 | |
| α-helix | 807-819 | 13 | |
| α-helix | 825-835 | 11 | |
| α-helix | 851-854 | 4 | |
| α-helix | 857-861 | 5 | |
| α-helix | 867-869 | 3 | |
| α-helix | 871-895 | 25 | |
| α-helix | 924-945 | 22 | |
| α-helix | 989-1007 | 19 | |
| α-helix | 1009-1018 | 10 | |
| α-helix | 1022-1024 | 3 | |
| α-helix | 1025-1029 | 5 | |
| α-helix | 1033-1041 | 9 | |
| α-helix | 1042-1046 | 5 | |
| α-helix | 1051-1067 | 17 | |
| α-helix | 1071-1086 | 16 | |
| α-helix | 1093-1100 | 8 | |
| α-helix | 1104-1113 | 10 | |
| α-helix | 1115-1117 | 3 | |
| α-helix | 1118-1136 | 19 | |
| α-helix | 1147-1150 | 4 | |
| α-helix | 1181-1201 | 21 | |
Chain D: 41 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 34-44 | 11 | |
| α-helix | 50-60 | 11 | |
| α-helix | 70-79 | 10 | |
| α-helix | 86-99 | 14 | |
| α-helix | 107-117 | 11 | |
| α-helix | 124-138 | 15 | |
| α-helix | 151-157 | 7 | |
| α-helix | 167-176 | 10 | |
| α-helix | 198-203 | 6 | |
| α-helix | 209-223 | 15 | |
| α-helix | 233-239 | 7 | |
| α-helix | 249-262 | 14 | |
| α-helix | 296-304 | 9 | |
| α-helix | 307-309 | 3 | |
| α-helix | 315-324 | 10 | |
| α-helix | 331-334 | 4 | |
| α-helix | 336-338 | 3 | |
| α-helix | 388-404 | 17 | |
| α-helix | 413-417 | 5 | |
| α-helix | 425-436 | 12 | |
| α-helix | 449-452 | 4 | |
| α-helix | 453-455 | 3 | |
| α-helix | 464-473 | 10 | |
| α-helix | 479-495 | 17 | |
| α-helix | 497-499 | 3 | |
| α-helix | 500-513 | 14 | |
| α-helix | 516-521 | 6 | |
| α-helix | 522-525 | 4 | |
| α-helix | 536-538 | 3 | |
| α-helix | 544-554 | 11 | |
| α-helix | 568-579 | 12 | |
| α-helix | 609-623 | 15 | |
| α-helix | 629-649 | 21 | |
| α-helix | 654-674 | 21 | |
| α-helix | 696-709 | 14 | |
| α-helix | 716-740 | 25 | |
| α-helix | 744-764 | 21 | |
| α-helix | 776-787 | 12 | |
| α-helix | 792-803 | 12 | |
| α-helix | 809-813 | 5 | |
| β-strand | 820-821 | 2 | 1 |
| β-strand | 845-847 | 3 | 2 |
| β-strand | 850-852 | 3 | 1 |
| β-strand | 861-866 | 6 | 3 |
| β-strand | 872-875 | 4 | 3 |
| α-helix | 876-877 | 2 | |
| β-strand | 882-886 | 5 | 1 |
| β-strand | 889-892 | 4 | 1 |
| β-strand | 895-897 | 3 | 2 |
| β-strand | 910-915 | 6 | 3 |
| β-strand | 929-930 | 2 | 3 |
Chain E: 56 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 187-203 | 17 | |
| α-helix | 211-223 | 13 | |
| α-helix | 226-239 | 14 | |
| α-helix | 248-261 | 14 | |
| α-helix | 266-273 | 8 | |
| α-helix | 275-278 | 4 | |
| α-helix | 284-287 | 4 | |
| α-helix | 289-291 | 3 | |
| α-helix | 294-314 | 21 | |
| α-helix | 319-330 | 12 | |
| α-helix | 338-347 | 10 | |
| α-helix | 355-368 | 14 | |
| α-helix | 384-392 | 9 | |
| α-helix | 393-395 | 3 | |
| α-helix | 398-401 | 4 | |
| α-helix | 404-412 | 9 | |
| α-helix | 419-430 | 12 | |
| α-helix | 440-458 | 19 | |
| α-helix | 467-469 | 3 | |
| α-helix | 472-477 | 6 | |
| α-helix | 478-480 | 3 | |
| α-helix | 481-488 | 8 | |
| α-helix | 495-509 | 15 | |
| α-helix | 515-524 | 10 | |
| α-helix | 529-542 | 14 | |
| α-helix | 550-562 | 13 | |
| α-helix | 568-586 | 19 | |
| α-helix | 591-594 | 4 | |
| α-helix | 599-603 | 5 | |
| α-helix | 604-606 | 3 | |
| α-helix | 607-610 | 4 | |
| α-helix | 612-615 | 4 | |
| α-helix | 619-629 | 11 | |
| α-helix | 641-661 | 21 | |
| α-helix | 664-666 | 3 | |
| α-helix | 668-678 | 11 | |
| α-helix | 682-695 | 14 | |
| α-helix | 733-737 | 5 | |
| β-strand | 753 | 1 | 4 |
| α-helix | 773-787 | 15 | |
| β-strand | 788 | 1 | 5 |
| α-helix | 789-790 | 2 | |
| α-helix | 802-803 | 2 | |
| β-strand | 804 | 1 | 5 |
| α-helix | 805 | 1 | |
| α-helix | 806-820 | 15 | |
| α-helix | 831-832 | 2 | |
| α-helix | 835-838 | 4 | |
| α-helix | 841-853 | 13 | |
| α-helix | 856-864 | 9 | |
| α-helix | 868-870 | 3 | |
| α-helix | 875-890 | 16 | |
| α-helix | 897-899 | 3 | |
| α-helix | 901-916 | 16 | |
| α-helix | 922-930 | 9 | |
| α-helix | 931-933 | 3 | |
| α-helix | 936-952 | 17 | |
| β-strand | 962 | 1 | 6 |
| β-strand | 969 | 1 | 6 |
| α-helix | 982-994 | 13 | |
| α-helix | 996-999 | 4 | |
Chain F: 19 helices, 25 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 4-7 | 4 | 7 |
| β-strand | 8 | 1 | 8 |
| α-helix | 12-15 | 4 | |
| β-strand | 17 | 1 | 9 |
| β-strand | 23 | 1 | 9 |
| α-helix | 24-39 | 16 | |
| β-strand | 50-53 | 4 | 7 |
| α-helix | 58-61 | 4 | |
| β-strand | 62-64 | 3 | 7 |
| α-helix | 70-78 | 9 | |
| α-helix | 88-99 | 12 | |
| β-strand | 124-125 | 2 | 7 |
| β-strand | 128 | 1 | 8 |
| β-strand | 135 | 1 | 10 |
| β-strand | 140 | 1 | 10 |
| α-helix | 145-147 | 3 | |
| α-helix | 151-152 | 2 | |
| β-strand | 167-168 | 2 | 7 |
| β-strand | 170-171 | 2 | 8 |
| β-strand | 191 | 1 | 8 |
| α-helix | 196-203 | 8 | |
| β-strand | 207-208 | 2 | 8 |
| α-helix | 213-223 | 11 | |
| β-strand | 231-232 | 2 | 11 |
| β-strand | 234 | 1 | 12 |
| β-strand | 265-267 | 3 | 11 |
| α-helix | 298-300 | 3 | |
| β-strand | 306 | 1 | 12 |
| β-strand | 307-310 | 4 | 13 |
| α-helix | 322-324 | 3 | |
| β-strand | 328-329 | 2 | 11 |
| α-helix | 330 | 1 | |
| α-helix | 335-338 | 4 | |
| β-strand | 349-352 | 4 | 13 |
| β-strand | 363-367 | 5 | 13 |
| β-strand | 370 | 1 | 14 |
| β-strand | 377 | 1 | 14 |
| β-strand | 381 | 1 | 13 |
| α-helix | 386-389 | 4 | |
| α-helix | 412-415 | 4 | |
| α-helix | 424-431 | 8 | |
| α-helix | 454-469 | 16 | |
| α-helix | 553-563 | 11 | |
| α-helix | 584-589 | 6 | |
Chain G: 42 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 22-34 | 13 | |
| α-helix | 38-54 | 17 | |
| α-helix | 58-73 | 16 | |
| α-helix | 79-89 | 11 | |
| α-helix | 101-108 | 8 | |
| α-helix | 116-128 | 13 | |
| α-helix | 137-146 | 10 | |
| α-helix | 153-167 | 15 | |
| α-helix | 170-185 | 16 | |
| α-helix | 191-197 | 7 | |
| α-helix | 198-203 | 6 | |
| α-helix | 208-224 | 17 | |
| α-helix | 228-244 | 17 | |
| α-helix | 249-262 | 14 | |
| α-helix | 266-282 | 17 | |
| α-helix | 289-300 | 12 | |
| α-helix | 306-319 | 14 | |
| α-helix | 323-327 | 5 | |
| α-helix | 344-350 | 7 | |
| α-helix | 351-353 | 3 | |
| α-helix | 357-373 | 17 | |
| α-helix | 379-392 | 14 | |
| α-helix | 403-422 | 20 | |
| α-helix | 424-426 | 3 | |
| α-helix | 428-437 | 10 | |
| α-helix | 446-456 | 11 | |
| α-helix | 461-477 | 17 | |
| α-helix | 486-500 | 15 | |
| α-helix | 507-517 | 11 | |
| α-helix | 523-536 | 14 | |
| α-helix | 540-550 | 11 | |
| α-helix | 557-575 | 19 | |
| α-helix | 584-605 | 22 | |
| α-helix | 616-640 | 25 | |
| α-helix | 646-649 | 4 | |
| α-helix | 667-692 | 26 | |
| α-helix | 697-719 | 23 | |
| α-helix | 743-759 | 17 | |
| α-helix | 773-784 | 12 | |
| α-helix | 793-795 | 3 | |
| β-strand | 802-804 | 3 | 15 |
| α-helix | 817-819 | 3 | |
| β-strand | 831-833 | 3 | 16 |
| β-strand | 835-837 | 3 | 15 |
| α-helix | 841-843 | 3 | |
| β-strand | 849-852 | 4 | 17 |
| β-strand | 853-858 | 6 | 18 |
| β-strand | 879-881 | 3 | 17 |
| β-strand | 888-890 | 3 | 16 |
| β-strand | 902-907 | 6 | 18 |
| β-strand | 910-911 | 2 | 17 |
| β-strand | 924-926 | 3 | 18 |
Chain H: 52 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 47-53 | 7 | |
| α-helix | 61-69 | 9 | |
| α-helix | 83-96 | 14 | |
| α-helix | 110-118 | 9 | |
| α-helix | 137-156 | 20 | |
| α-helix | 161-165 | 5 | |
| α-helix | 171-191 | 21 | |
| α-helix | 195-206 | 12 | |
| α-helix | 213-232 | 20 | |
| α-helix | 242-258 | 17 | |
| α-helix | 269-282 | 14 | |
| α-helix | 327-336 | 10 | |
| α-helix | 340-347 | 8 | |
| α-helix | 356-371 | 16 | |
| α-helix | 378-395 | 18 | |
| α-helix | 398-400 | 3 | |
| α-helix | 401-407 | 7 | |
| α-helix | 412-422 | 11 | |
| α-helix | 435-445 | 11 | |
| α-helix | 446-448 | 3 | |
| α-helix | 453-459 | 7 | |
| α-helix | 462-464 | 3 | |
| α-helix | 467-469 | 3 | |
| α-helix | 474-484 | 11 | |
| α-helix | 498-499 | 2 | |
| α-helix | 506-517 | 12 | |
| α-helix | 522-535 | 14 | |
| α-helix | 552-558 | 7 | |
| α-helix | 564-582 | 19 | |
| α-helix | 586-600 | 15 | |
| α-helix | 605-621 | 17 | |
| α-helix | 622-626 | 5 | |
| α-helix | 637-648 | 12 | |
| α-helix | 657-669 | 13 | |
| α-helix | 689-701 | 13 | |
| α-helix | 712-724 | 13 | |
| β-strand | 726 | 1 | 19 |
| α-helix | 740-744 | 5 | |
| α-helix | 756-762 | 7 | |
| α-helix | 767-781 | 15 | |
| β-strand | 809 | 1 | 19 |
| α-helix | 811-828 | 18 | |
| α-helix | 833-845 | 13 | |
| α-helix | 849-863 | 15 | |
| α-helix | 865-867 | 3 | |
| α-helix | 870-872 | 3 | |
| α-helix | 878-889 | 12 | |
| α-helix | 894-900 | 7 | |
| α-helix | 909-916 | 8 | |
| α-helix | 925-927 | 3 | |
| α-helix | 929-931 | 3 | |
| α-helix | 935-947 | 13 | |
| α-helix | 951-961 | 11 | |
| α-helix | 975-993 | 19 | |
Chain I: 19 helices, 23 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 10 | 1 | 20 |
| β-strand | 24 | 1 | 20 |
| β-strand | 32-34 | 3 | 21 |
| β-strand | 45 | 1 | 22 |
| α-helix | 46-48 | 3 | |
| β-strand | 60 | 1 | 23 |
| β-strand | 71-72 | 2 | 23 |
| β-strand | 74-75 | 2 | 23 |
| β-strand | 77 | 1 | 22 |
| β-strand | 98-100 | 3 | 21 |
| α-helix | 111-113 | 3 | |
| β-strand | 122-125 | 4 | 21 |
| α-helix | 127-145 | 19 | |
| α-helix | 149-151 | 3 | |
| α-helix | 186-189 | 4 | |
| β-strand | 194-196 | 3 | 21 |
| α-helix | 205-207 | 3 | |
| β-strand | 210-212 | 3 | 24 |
| β-strand | 226-228 | 3 | 24 |
| β-strand | 236-237 | 2 | 25 |
| β-strand | 262-263 | 2 | 25 |
| α-helix | 274-290 | 17 | |
| β-strand | 295-299 | 5 | 26 |
| α-helix | 305-314 | 10 | |
| α-helix | 315-317 | 3 | |
| β-strand | 326-329 | 4 | 26 |
| α-helix | 333-342 | 10 | |
| α-helix | 363-367 | 5 | |
| α-helix | 369-372 | 4 | |
| β-strand | 392-396 | 5 | 26 |
| α-helix | 405-411 | 7 | |
| α-helix | 454-464 | 11 | |
| α-helix | 469-471 | 3 | |
| α-helix | 478-479 | 2 | |
| β-strand | 529-531 | 3 | 27 |
| α-helix | 591-601 | 11 | |
| β-strand | 606-610 | 5 | 28 |
| β-strand | 615-619 | 5 | 28 |
| α-helix | 621-623 | 3 | |
| β-strand | 624-629 | 6 | 28 |
| β-strand | 632-637 | 6 | 28 |
| α-helix | 642-652 | 11 | |
4 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Integrator complex subunit 1 | A | protein | 2190 | Homo sapiens | Q8N201 (AlphaFold model) |
| Integrator complex subunit 2 | B | protein | 1204 | Homo sapiens | Q9H0H0 (AlphaFold model) |
| Integrator complex subunit 4 | D | protein | 963 | Homo sapiens | Q96HW7 (AlphaFold model) |
| Integrator complex subunit 5 | E | protein | 1019 | Homo sapiens | Q6P9B9 (AlphaFold model) |
| Integrator complex subunit 6 | F | protein | 887 | Homo sapiens | Q9UL03 |
| Integrator complex subunit 7 | G | protein | 962 | Homo sapiens | Q9NVH2 |
| Integrator complex subunit 8 | H | protein | 995 | Homo sapiens | Q75QN2 |
| Integrator complex subunit 9 | I | protein | 658 | Homo sapiens | Q9NV88 |
| Integrator complex subunit 11 | K | protein | 600 | Homo sapiens | Q5TA45 |
| PP2A-a | P | protein | 589 | Homo sapiens | P30153 |
| PP2A-C | Q | protein | 309 | Homo sapiens | P67775 |
| unknown | U | protein | 594 | Homo sapiens | |
Sequence of entity 1 (A), FASTA
>7CUN_1 Integrator complex subunit 1 (chains A)
MNRAKPTTVRRPSAAAKPSGHPPPGDFIALGSKGQANESKTASTLLKPAPSGLPSERKRD
AAAALSSASALTGLTKRPKLSSTPPLSALGRLAEAAVAEKRAISPSIKEPSVVPIEVLPT
VLLDEIEAAELEGNDDRIEGVLCGAVKQLKVTRAKPDSTLYLSLMYLAKIKPNIFATEGV
IEALCSLLRRDASINFKAKGNSLVSVLACNLLMAAYEEDENWPEIFVKVYIEDSLGERIW
VDSPHCKTFVDNIQTAFNTRMPPRSVLLQGEAGRVAGDLGAGSSPHPSLTEEEDSQTELL
IAEEKLSPEQEGQLMPRYEELAESVEEYVLDMLRDQLNRRQPIDNVSRNLLRLLTSTCGY
KEVRLLAVQKLEMWLQNPKLTRPAQDLLMSVCMNCNTHGSEDMDVISHLIKIRLKPKVLL
NHFMLCIRELLSAHKDNLGTTIKLVIFNELSSARNPNNMQVLYTALQHSSELAPKFLAMV
FQDLLTNKDDYLRASRALLREIIKQTKHEINFQAFCLGLMQERKEPQYLEMEFKERFVVH
ITDVLAVSMMLGITAQVKEAGIAWDKGEKRNLEVLRSFQNQIAAIQRDAVWWLHTVVPSI
SKLAPKDYVHCLHKVLFTEQPETYYKWDNWPPESDRNFFLRLCSEVPILEDTLMRILVIG
LSRELPLGPADAMELADHLVKRAAAVQADDVEVLKVGRTQLIDAVLNLCTYHHPENIQLP
PGYQPPNLAISTLYWKAWPLLLVVAAFNPENIGLAAWEEYPTLKMLMEMVMTNNYSYPPC
TLTDEETRTEMLNRELQTAQREKQEILAFEGHLAAASTKQTITESSSLLLSQLTSLDPQG
PPRRPPPHILDQVKSLNQSLRLGHLLCRSRNPDFLLHIIQRQASSQSMPWLADLVQSSEG
SLDVLPVQCLCEFLLHDAVDDAASGEEDDEGESKEQKAKKRQRQQKQRQLLGRLQDLLLG
PKADEQTTCEVLDYFLRRLGSSQVASRVLAMKGLSLVLSEGSLRDGEEKEPPMEEDVGDT
DVLQGYQWLLRDLPRLPLFDSVRSTTALALQQAIHMETDPQTISAYLIYLSQHTPVEEQA
QHSDLALDVARLVVERSTIMSHLFSKLSPSAASDAVLSALLSIFSRYVRRMRQSKEGEEV
YSWSESQDQVFLRWSSGETATMHILVVHAMVILLTLGPPRADDSEFQALLDIWFPEEKPL
PTAFLVDTSEEALLLPDWLKLRMIRSEVLRLVDAALQDLEPQQLLLFVQSFGIPVSSMSK
LLQFLDQAVAHDPQTLEQNIMDKNYMAHLVEVQHERGASGGQTFHSLLTASLPPRRDSTE
APKPKSSPEQPIGQGRIRVGTQLRVLGPEDDLAGMFLQIFPLSPDPRWQSSSPRPVALAL
QQALGQELARVVQGSPEVPGITVRVLQALATLLSSPHGGALVMSMHRSHFLACPLLRQLC
QYQRCVPQDTGFSSLFLKVLLQMLQWLDSPGVEGGPLRAQLRMLASQASAGRRLSDVRGG
LLRLAEALAFRQDLEVVSSTVRAVIATLRSGEQCSVEPDLISKVLQGLIEVRSPHLEELL
TAFFSATADAASPFPACKPVVVVSSLLLQEEEPLAGGKPGADGGSLEAVRLGPSSGLLVD
WLEMLDPEVVSSCPDLQLRLLFSRRKGKGQAQVPSFRPYLLTLFTHQSSWPTLHQCIRVL
LGKSREQRFDPSASLDFLWACIHVPRIWQGRDQRTPQKRREELVLRVQGPELISLVELIL
AEAETRSQDGDTAACSLIQARLPLLLSCCCGDDESVRKVTEHLSGCIQQWGDSVLGRRCR
DLLLQLYLQRPELRVPVPEVLLHSEGAASSSVCKLDGLIHRFITLLADTSDSRALENRGA
DASMACRKLAVAHPLLLLRHLPMIAALLHGRTHLNFQEFRQQNHLSCFLHVLGLLELLQP
HVFRSEHQGALWDCLLSFIRLLLNYRKSSRHLAAFINKFVQFIHKYITYNAPAAISFLQK
HADPLHDLSFDNSDLVMLKSLLAGLSLPSRDDRTDRGLDEEGEEESSAGSLPLVSVSLFT
PLTAAEMAPYMKRLSRGQTVEDLLEVLSDIDEMSRRRPEILSFFSTNLQRLMSSAEECCR
NLAFSLALRSMQNSPSIAAAFLPTFMYCLGSQDFEVVQTALRNLPEYALLCQEHAAVLLH
RAFLVGMYGQMDPSAQISEALRILHMEAVM
Sequence of entity 2 (B), FASTA
>7CUN_2 Integrator complex subunit 2 (chains B)
MKDQQTVIMTECTSLQFVSPFAFEAMQKVDVVCLASLSDPELRLLLPCLVRMALCAPADQ
SQSWAQDKKLILRLLSGVEAVNSIVALLSVDFHALEQDASKEQQLRHKLGGGSGESILVS
QLQHGLTLEFEHSDSPRRLRLVLSELLAIMNKVSESNGEFFFKSSELFESPVYLEEAADV
LCILQAELPSLLPIVDVAEALLHVRNGAWFLCLLVANVPDSFNEVCRGLIKNGERQDEES
LGGRRRTDALRFLCKMNPSQALKVRGMVVEECHLPGLGVALTLDHTKNEACEDGVSDLVC
FVSGLLLGTNAKVRTWFGTFIRNGQQRKRETSSSVLWQMRRQLLLELMGILPTVRSTRIV
EEADVDMEPNVSVYSGLKEEHVVKASALLRLYCALMGIAGLKPTEEEAEQLLQLMTSRPP
ATPAGVRFVSLSFCMLLAFSTLVSTPEQEQLMVVWLSWMIKEEAYFESTSGVSASFGEML
LLVAMYFHSNQLSAIIDLVCSTLGMKIVIKPSSLSRMKTIFTQEIFTEQVVTAHAVRVPV
TSNLSANITGFLPIHCIYQLLRSRSFTKHKVSIKDWIYRQLCETSTPLHPQLLPLIDVYI
NSILTPASKSNPEATNQPVTEQEILNIFQGVIGGDNIRLNQRFSITAQLLVLYYILSYEE
ALLANTKTLAAMQRKPKSYSSSLMDQIPIKFLIRQAQGLQQELGGLHSALLRLLATNYPH
LCIVDDWICEEEITGTDALLRRMLLTNNAKNHSPKQLQEAFSAVPVNNTQVMQIIEHLTL
LSASELIPYAEVLTSNMSQLLNSGVPRRILQTVNKLWMVLNTVMPRRLWVMTVNALQPSI
KFVRQQKYTQNDLMIDPLIVLRCDQRVHRCPPLMDITLHMLNGYLLASKAYLSAHLKETE
QDRPSQNNTIGLVGQTDAPEVTREELKNALLAAQDSAAVQILLEICLPTEEEKANGVNPD
SLLRNVQSVITTSAPNKGMEEGEDNLLCNLREVQCLICCLLHQMYIADPNIAKLVHFQGY
PCELLPLTVAGIPSMHICLDFIPELIAQPELEKQIFAIQLLSHLCIQYALPKSLSVARLA
VNVMGTLLTVLTQAKRYAFFMPTLPSLVSFCRAFPPLYEDIMSLLIQIGQVCASDVATQT
RDIDPIITRLQQIKEKPSGWSQICKDSSYKNGSRDTGSMDPDVQLCHCIERTVIEIINMS
VSGI
Sequence of entity 3 (D), FASTA
>7CUN_3 Integrator complex subunit 4 (chains D)
MAAHLKKRVYEEFTKVVQPQEEIATKKLRLTKPSKSAALHIDLCKATSPADALQYLLQFA
RKPVEAESVEGVVRILLEHYYKENDPSVRLKIASLLGLLSKTAGFSPDCIMDDAINILQN
EKSHQVLAQLLDTLLAIGTKLPENQAIQMRLVDVACKHLTDTSHGVRNKCLQLLGNLGSL
EKSVTKDAEGLAARDVQKIIGDYFSDQDPRVRTAAIKAMLQLHERGLKLHQTIYNQACKL
LSDDYEQVRSAAVQLIWVVSQLYPESIVPIPSSNEEIRLVDDAFGKICHMVSDGSWVVRV
QAAKLLGSMEQVSSHFLEQTLDKKLMSDLRRKRTAHERAKELYSSGEFSSGRKWGDDAPK
EEVDTGAVNLIESGACGAFVHGLEDEMYEVRIAAVEALCMLAQSSPSFAEKCLDFLVDMF
NDEIEEVRLQSIHTMRKISNNITLREDQLDTVLAVLEDSSRDIREALHELLCCTNVSTKE
GIHLALVELLKNLTKYPTDRDSIWKCLKFLGSRHPTLVLPLVPELLSTHPFFDTAEPDMD
DPAYIAVLVLIFNAAKTCPTMPALFSDHTFRHYAYLRDSLSHLVPALRLPGRKLVSSAVS
PSIIPQEDPSQQFLQQSLERVYSLQHLDPQGAQELLEFTIRDLQRLGELQSELAGVADFS
ATYLRCQLLLIKALQEKLWNVAAPLYLKQSDLASAAAKQIMEETYKMEFMYSGVENKQVV
IIHHMRLQAKALQLIVTARTTRGLDPLFGMCEKFLQEVDFFQRYFIADLPHLQDSFVDKL
LDLMPRLMTSKPAEVVKILQTMLRQSAFLHLPLPEQIHKASATIIEPAGESDNPLRFTSG
LVVALDVDATLEHVQDPQNTVKVQVLYPDGQAQMIHPKPADFRNPGPGRHRLITQVYLSH
TAWTEACQVEVRLLLAYNSSARIPKCPWMEGGEMSPQVETSIEGTIPFSKPVKVYIMPKP
ARR
Sequence of entity 4 (E), FASTA
>7CUN_4 Integrator complex subunit 5 (chains E)
MSALCDPPGAPGPPGPAPATHGPAPLSAQELSQEIKAFLTGVDPILGHQLSAREHARCGL
LLLRSLPPARAAVLDHLRGVFDESVRAHLAALDETPVAGPPHLRPPPPSHVPAGGPGLED
VVQEVQQVLSEFIRANPKAWAPVISAWSIDLMGQLSSTYSGQHQRVPHATGALNELLQLW
MGCRATRTLMDIYVQCLSALIGSCPDACVDALLDTSVQHSPHFDWVVAHIGSSFPGTIIS
RVLSCGLKDFCVHGGAGGGAGSSGGSSSQTPSTDPFPGSPAIPAEKRVPKIASVVGILGH
LASRHGDSIRRELLRMFHDSLAGGSGGRSGDPSLQATVPFLLQLAVMSPALLGTVSGELV
DCLKPPAVLSQLQQHLQGFPREELDNMLNLAVHLVSQASGAGAYRLLQFLVDTAMPASVI
TTQGLAVPDTVREACDRLIQLLLLHLQKLVHHRGGSPGEGVLGPPPPPRLVPFLDALKNH
VGELCGETLRLERKRFLWQHQLLGLLSVYTRPSCGPEALGHLLSRARSPEELSLATQLYA
GLVVSLSGLLPLAFRSCLARVHAGTLQPPFTARFLRNLALLVGWEQQGGEGPAALGAHFG
ESASAHLSDLAPLLLHPEEEVAEAAASLLAICPFPSEALSPSQLLGLVRAGVHRFFASLR
LHGPPGVASACQLLTRLSQTSPAGLKAVLQLLVEGALHRGNTELFGGQVDGDNETLSVVS
ASLASASLLDTNRRHTAAVPGPGGIWSVFHAGVIGRGLKPPKFVQSRNQQEVIYNTQSLL
SLLVHCCSAPGGTECGECWGAPILSPEAAKAVAVTLVESVCPDAAGAELAWPPEEHARAT
VERDLRIGRRFREQPLLFELLKLVAAAPPALCYCSVLLRGLLAALLGHWEASRHPDTTHS
PWHLEASCTLVAVMAEGSLLPPALGNMHEVFSQLAPFEVRLLLLSVWGFLREHGPLPQKF
IFQSERGRFIRDFSREGGGEGGPHLAVLHSVLHRNIDRLGLFSGRFQAPSPSTLLRQGT
Sequence of entity 5 (F), FASTA
>7CUN_5 Integrator complex subunit 6 (chains F)
MPILLFLIDTSASMNQRSHLGTTYLDTAKGAVETFMKLRARDPASRGDRYMLVTFEEPPY
AIKAGWKENHATFMNELKNLQAEGLTTLGQSLRTAFDLLNLNRLVTGIDNYGQGRNPFFL
EPAIIITITDGSKLTTTSGVQDELHLPLNSPLPGSELTKEPFRWDQRLFALVLRLPGTMS
VESEQLTGVPLDDSAITPMCEVTGGRSYSVCSPRMLNQCLESLVQKVQSGVVINFEKAGP
DPSPVEDGQPDISRPFGSQPWHSCHKLIYVRPNPKTGVPIGHWPVPESFWPDQNSPTLPP
RTSHPVVKFSCTDCEPMVIDKLPFDKYELEPSPLTQFILERKSPQTCWQVYVSNSAKYSE
LGHPFGYLKASTALNCVNLFVMPYNYPVLLPLLDDLFKVHKAKPTLKWRQSFESYLKTMP
PYYLGPLKKAVRMMGAPNLIADSMEYGLSYSVISYLKKLSQQAKIESDRVIGSVGKKVVQ
ETGIKVRSRSHGLSMAYRKDFQQLLQGISEDVPHRLLDLNMKEYTGFQVALLNKDLKPQT
FRNAYDIPRRNLLDHLTRMRSNLLKSTRRFLKGQDEDQVHSVPIAQMGNYQEYLKQVPSP
LRELDPDQPRRLHTFGNPFKLDKKGMMIDEADEFVAGPQNKHKRPGEPNMQGIPKRRRCM
SPLLRGRQQNPVVNNHIGGKGPPAPTTQAQPDLIKPLPLHKISETTNDSIIHDVVENHVA
DQLSSDITPNAMDTEFSASSPASLLERPTNHMEALGHDHLGTNDLTVGGFLENHEEPRDK
EQCAEENIPASSLNKGKKLMHCRSHEEVNTELKAQIMKEIRKPGRKYERIFTLLKHVQGS
LQTRLIFLQNVIKEASRFKKRMLIEQLENFLDEIHRRANQINHINSN
Sequence of entity 6 (G), FASTA
>7CUN_6 Integrator complex subunit 7 (chains G)
MASNSTKSFLADAGYGEQELDANSALMELDKGLRSGKLGEQCEAVVRFPRLFQKYPFPIL
INSAFLKLADVFRVGNNFLRLCVLKVTQQSEKHLEKILNVDEFVKRIFSVIHSNDPVARA
ITLRMLGSLASIIPERKNAHHSIRQSLDSHDNVEVEAAVFAAANFSAQSKDFAVGICNKI
SEMIQGLATPVDLKLKLIPILQHMHHDAILASSARQLLQQLVTSYPSTKMVIVSLHTFTL
LAASSLVDTPKQIQLLLQYLKNDPRKAVKRLAIQDLKLLANKTPHTWSRENIQALCECAL
QTPYDSLKLGMLSVLSTLSGTIAIKHYFSIVPGNVSSSPRSSDLVKLAQECCYHNNRGIA
AHGVRVLTNITVSCQEKDLLALEQDAVFGLESLLVLCSQDDSPGAQATLKIALNCMVKLA
KGRPHLSQSVVETLLTQLHSAQDAARILMCHCLAAIAMQLPVLGDGMLGDLMELYKVIGR
SATDKQQELLVSLATVIFVASQKALSVESKAVIKQQLESVSNGWTVYRIARQASRMGNHD
MAKELYQSLLTQVASEHFYFWLNSLKEFSHAEQCLTGLQEENYSSALSCIAESLKFYHKG
IASLTAASTPLNPLSFQCEFVKLRIDLLQAFSQLICTCNSLKTSPPPAIATTIAMTLGND
LQRCGRISNQMKQSMEEFRSLASRYGDLYQASFDADSATLRNVELQQQSCLLISHAIEAL
ILDPESASFQEYGSTGTAHADSEYERRMMSVYNHVLEEVESLNRKYTPVSYMHTACLCNA
IIALLKVPLSFQRYFFQKLQSTSIKLALSPSPRNPAEPIAVQNNQQLALKVEGVVQHGSK
PGLFRKIQSVCLNVSSTLQSKSGQDYKIPIDNMTNEMEQRVEPHNDYFSTQFLLNFAILG
THNITVESSVKDANGIVWKTGPRTTIFVKSLEDPYSQQIRLQQQQAQQPLQQQQQRNAYT
RF
Sequence of entity 7 (H), FASTA
>7CUN_7 Integrator complex subunit 8 (chains H)
MSAEAADREAATSSRPCTPPQTCWFEFLLEESLLEKHLRKPCPDPAPVQLIVQFLEQASK
PSVNEQNQVQPPPDNKRNRILKLLALKVAAHLKWDLDILEKSLSVPVLNMLLNELLCISK
VPPGTKHVDMDLATLPPTTAMAVLLYNRWAIRTIVQSSFPVKQAKPGPPQLSVMNQMQQE
KELTENILKVLKEQAADSILVLEAALKLNKDLYVHTMRTLDLLAMEPGMVNGETESSTAG
LKVKTEEMQCQVCYDLGAAYFQQGSTNSAVYENAREKFFRTKELIAEIGSLSLHCTIDEK
RLAGYCQACDVLVPSSDSTSQQLTPYSQVHICLRSGNYQEVIQIFIEDNLTLSLPVQFRQ
SVLRELFKKAQQGNEALDEICFKVCACNTVRDILEGRTISVQFNQLFLRPNKEKIDFLLE
VCSRSVNLEKASESLKGNMAAFLKNVCLGLEDLQYVFMISSHELFITLLKDEERKLLVDQ
MRKRSPRVNLCIKPVTSFYDIPASASVNIGQLEHQLILSVDPWRIRQILIELHGMTSERQ
FWTVSNKWEVPSVYSGVILGIKDNLTRDLVYILMAKGLHCSTVKDFSHAKQLFAACLELV
TEFSPKLRQVMLNEMLLLDIHTHEAGTGQAGERPPSDLISRVRGYLEMRLPDIPLRQVIA
EECVAFMLNWRENEYLTLQVPAFLLQSNPYVKLGQLLAATCKELPGPKESRRTAKDLWEV
VVQICSVSSQHKRGNDGRVSLIKQRESTLGIMYRSELLSFIKKLREPLVLTIILSLFVKL
HNVREDIVNDITAEHISIWPSSIPNLQSVDFEAVAITVKELVRYTLSINPNNHSWLIIQA
DIYFATNQYSAALHYYLQAGAVCSDFFNKAVPPDVYTDQVIKRMIKCCSLLNCHTQVAIL
CQFLREIDYKTAFKSLQEQNSHDAMDSYYDYIWDVTILEYLTYLHHKRGETDKRQIAIKA
IGQTELNASNPEEVLQLAAQRRKKKFLQAMAKLYF
Sequence of entity 8 (I), FASTA
>7CUN_8 Integrator complex subunit 9 (chains I)
MKLYCLSGHPTLPCNVLKFKSTTIMLDCGLDMTSTLNFLPLPLVQSPRLSNLPGWSLKDG
NAFLDKELKECSGHVFVDSVPEFCLPETELIDLSTVDVILISNYHCMMALPYITEHTGFT
GTVYATEPTVQIGRLLMEELVNFIERVPKAQSASLWKNKDIQRLLPSPLKDAVEVSTWRR
CYTMQEVNSALSKIQLVGYSQKIELFGAVQVTPLSSGYALGSSNWIIQSHYEKVSYVSGS
SLLTTHPQPMDQASLKNSDVLVLTGLTQIPTANPDGMVGEFCSNLALTVRNGGNVLVPCY
PSGVIYDLLECLYQYIDSAGLSSVPLYFISPVANSSLEFSQIFAEWLCHNKQSKVYLPEP
PFPHAELIQTNKLKHYPSIHGDFSNDFRQPCVVFTGHPSLRFGDVVHFMELWGKSSLNTV
IFTEPDFSYLEALAPYQPLAMKCIYCPIDTRLNFIQVSKLLKEVQPLHVVCPEQYTQPPP
AQSHRMDLMIDCQPPAMSYRRAEVLALPFKRRYEKIEIMPELADSLVPMEIKPGISLATV
SAVLHTKDNKHLLQPPPRPAQPTSGKKRKRVSDDVPDCKVLKPLLSGSIPVEQFVQTLEK
HGFSDIKVEDTAKGHIVLLQEAETLIQIEEDSTHIICDNDEMLRVRLRDLVLKFLQKF
Sequence of entity 9 (K), FASTA
>7CUN_9 Integrator complex subunit 11 (chains K)
MPEIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYITQNGRLTDF
LDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICPILLEDYRKIAVDKKGEANF
FTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYN
MTPDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVF
ALGRAQELCILLETFWERMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRNMF
EFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVG
HKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLVHGEAKKM
EFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLGLLKREMAQGLLPEAKKPRLLH
GTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHDTRKEQETALRVYSHLKSVLKD
HCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLVSWTYQDEELGSFLTSLLKKGLPQAPS
Sequence of entity 10 (P), FASTA
>7CUN_10 PP2A-A (chains P)
MAAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIY
DEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHS
PSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPM
VRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDL
EALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRA
AASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDN
TIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVR
LAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHA
TIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNV
AKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA
Sequence of entity 11 (Q), FASTA
>7CUN_11 PP2A-C (chains Q)
MDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHG
QFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHES
RQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHI
RALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRA
HQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHV
TRRTPDYFL
Sequence of entity 12 (U), FASTA
>7CUN_12 unknown (chains U)
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| MN | Manganese (II) ion | Mn | 2 |
| ZN | Zinc ion | Zn | 2 |
Primary citation
Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase. Zheng, H., Qi, Y., Hu, S. et al. Science (2020) 370. DOI 10.1126/science.abb5872 · PubMed
Other PDB entries of the same protein (UniProt Q8N201 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 8RC4 3.1 Å, Structure of Integrator-PP2A complex
- 7PKS 3.6 Å, Structural basis of Integrator-mediated transcription regulation
- 8RBZ 3.7 Å, Structure of Integrator-PP2A-SOSS-CTD post-termination complex
- 8RBX 4.1 Å, Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome…
- 8YJB 4.1 Å, Cryo-EM structure of the human DSS1-INTAC complex
- 7YCX 4.18 Å, The structure of INTAC-PEC complex
- 9VD9 4.6 Å, Cryo-EM structure of the human DSS1-INTAC-PEC complex
Browse structure collections
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