Crystal structure of Rsu1/PINCH1_LIM5C complex. Determined by X-ray diffraction at 1.65 Å resolution. Released 24 Feb 2021.
Explore 7D2S in 3D Show helices and sheets RCSB PDB PDBe
7D2S contains 13 α-helices and 18 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 5-14 | 10 | |
| β-strand | 19-21 | 3 | 1 |
| α-helix | 30-32 | 3 | |
| α-helix | 36-38 | 3 | |
| β-strand | 44-46 | 3 | 1 |
| β-strand | 54 | 1 | 2 |
| α-helix | 57-61 | 5 | |
| β-strand | 67-69 | 3 | 1 |
| β-strand | 77 | 1 | 2 |
| α-helix | 80-84 | 5 | |
| β-strand | 90-92 | 3 | 1 |
| α-helix | 105-107 | 3 | |
| β-strand | 113-115 | 3 | 1 |
| α-helix | 123-125 | 3 | |
| α-helix | 130-132 | 3 | |
| β-strand | 138-140 | 3 | 1 |
| α-helix | 151-155 | 5 | |
| β-strand | 161-163 | 3 | 1 |
| α-helix | 174-178 | 5 | |
| β-strand | 184-186 | 3 | 1 |
| α-helix | 197-199 | 3 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 251 | 1 | 3 |
| β-strand | 258 | 1 | 3 |
| β-strand | 263-266 | 4 | 4 |
| β-strand | 269-272 | 4 | 4 |
| β-strand | 277 | 1 | 5 |
| β-strand | 284 | 1 | 5 |
| β-strand | 291-294 | 4 | 6 |
| β-strand | 297-300 | 4 | 6 |
| α-helix | 301-305 | 5 | |
| α-helix | 309-317 | 9 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Ras suppressor protein 1 | A | protein | 220 | Homo sapiens | Q15404 (AlphaFold model) |
| LIM and senescent cell antigen-like-containing domain protein 1 | B | protein | 81 | Homo sapiens | P48059 (AlphaFold model) |
>7D2S_1 Ras suppressor protein 1 (chains A) GAMGSMSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMV PPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLD LTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKE IGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAEN
>7D2S_2 LIM and senescent cell antigen-like-containing domain protein 1 (chains B) GPGSGDVCFHCNRVIEGDVVSALNKAWCVNCFACSTCNTKLTLKNKFVEFDMKPVCKKCY EKFPLELKKRLKKLAETLGRK
| ID | Name | Formula | Copies |
|---|---|---|---|
| ZN | Zinc ion | Zn | 2 |
Water and common crystallization additives (GOL) are not listed.
Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics. Yang, H., Lin, L., Sun, K. et al. Elife (2021) 10. DOI 10.7554/eLife.64395 · PubMed
Other PDB entries of the same protein (UniProt Q15404 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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