LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1) is a 325-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P48059.
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The mean pLDDT of this model is 88.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 48% |
| 70 to 90 | Confident: backbone generally right | 49% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration
Component of the heterotrimeric IPP (ILK-PINCH-PARVIN) complex composed of ILK, LIMS1/PINCH and PARVA; the complex binds to F-actin via the C-terminal tail of LIMS1 and the N-terminal region of PARVA, promoting F-actin filament bundling (PubMed:11331308, PubMed:12432066, PubMed:30367047). Formation of the IPP complex is dependent on protein kinase C and precedes integrin-mediated cell adhesion…
Cell junction, focal adhesion, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4HI8 | X-ray | 1.2 Å | B=6-68 |
| 4HI9 | X-ray | 1.2 Å | B=6-68 |
| 3F6Q | X-ray | 1.6 Å | B=6-68 |
| 7D2S | X-ray | 1.65 Å | B=249-325 |
| 7D2T | X-ray | 2.2 Å | B/D=188-325 |
| 7LT9 | X-ray | 3.05 Å | B=189-325 |
| 7D2U | X-ray | 3.15 Å | B=188-325 |
| 1G47 | NMR | A=1-70 | |
| 1NYP | NMR | A=188-251 | |
| 1U5S | NMR | B=188-251 | |
| 2COR | NMR | A=125-190 | |
| 2D8X | NMR | A=71-127 | |
| 2KBX | NMR | B=1-70 | |
| 6MIF | NMR | A=249-325 |
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