7SIL: PDB entry 7SIL

Structure of positive allosteric modulator-bound active human calcium-sensing receptor. Determined by electron microscopy at 2.7 Å resolution. Released 19 Jan 2022.

Method
Electron microscopy
Resolution
2.7 Å
Organism
Homo sapiens
Chains
2
Atoms
12,924
Mol. weight
206.27 kDa
Ligands
CLR, 9IG, CA, PO4
Released
19 Jan 2022

Explore 7SIL in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7SIL contains 81 α-helices and 78 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 41 helices, 40 β-strands

ElementResiduesLengthSheet
β-strand25-2841
β-strand32-3871
β-strand4112
β-strand4413
α-helix54-596
β-strand6013
β-strand6312
α-helix65-8319
β-strand93-9971
α-helix104-11411
α-helix116-1205
α-helix136-1372
β-strand138-14251
α-helix147-15913
β-strand164-16631
α-helix172-1754
β-strand183-18531
α-helix191-20313
β-strand208-21474
α-helix219-23214
β-strand236-24384
α-helix249-26113
β-strand266-27054
α-helix273-28614
β-strand292-29544
α-helix2961
α-helix308-3103
α-helix311-3144
β-strand318-32254
α-helix323-3242
β-strand32515
α-helix330-3356
β-strand34511
α-helix348-3569
β-strand35916
β-strand39416
α-helix401-4033
β-strand41415
α-helix416-43520
α-helix445-4473
α-helix452-4543
α-helix457-4659
β-strand469-47027
β-strand476-47727
β-strand489-49684
β-strand503-51194
α-helix5161
β-strand521-52334
α-helix525-5273
β-strand53018
β-strand53418
α-helix537-5393
β-strand550-55129
β-strand554110
β-strand563110
β-strand566-56729
α-helix568-5692
β-strand573111
α-helix5821
β-strand583111
α-helix584-5852
β-strand589-591312
β-strand598-600312
α-helix6011
β-strand602-604313
β-strand606114
α-helix611-63626
α-helix641-6455
α-helix648-66821
β-strand670114
α-helix674-6785
α-helix681-70222
α-helix723-74523
β-strand749-753513
β-strand760-766713
α-helix770-79324
α-helix803-82018
α-helix822-8254
α-helix832-84918
α-helix850-8545
α-helix855-8606
Chain B: 40 helices, 38 β-strands
ElementResiduesLengthSheet
β-strand25-28415
β-strand32-38715
β-strand41116
β-strand44117
α-helix54-585
β-strand60117
β-strand63116
α-helix65-8319
β-strand93-99715
α-helix104-11411
α-helix116-1205
α-helix136-1372
β-strand138-142515
α-helix147-15913
β-strand164-166315
α-helix172-1754
β-strand183-185315
α-helix191-20313
β-strand208-214718
α-helix219-23214
β-strand236-243818
α-helix249-26113
β-strand266-270518
α-helix273-28614
β-strand292-295418
α-helix2961
α-helix308-3103
α-helix311-3144
β-strand318-322518
α-helix323-3242
β-strand325119
α-helix330-3356
β-strand345115
α-helix348-3558
β-strand359120
β-strand394120
α-helix401-4033
β-strand414119
α-helix416-43520
α-helix445-4473
α-helix452-4543
α-helix457-4659
β-strand468-470321
β-strand476-478321
β-strand489-496818
β-strand503-511918
α-helix5161
β-strand521-523318
α-helix525-5273
β-strand530122
β-strand534122
α-helix537-5393
β-strand550-551223
β-strand554124
β-strand563124
β-strand566-567223
α-helix568-5692
β-strand572-573225
β-strand583-584225
α-helix5851
β-strand589-591326
β-strand598-600326
α-helix6011
β-strand602-604327
α-helix611-63626
α-helix641-6455
α-helix648-66821
α-helix674-6785
α-helix681-70222
α-helix723-74523
β-strand749-753527
β-strand760-766727
α-helix770-79324
α-helix803-82018
α-helix822-8254
α-helix832-84918
α-helix850-8545
α-helix855-8606

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Isoform 1 of Extracellular calcium-sensing receptorA, Bprotein878Homo sapiensP41180 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>7SIL_1 Isoform 1 of Extracellular calcium-sensing receptor (chains A, B)
MAFYSCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVEC
IRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKI
DSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQF
KSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFS
ELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWA
SSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHL
QEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNV
YLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFD
ECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFS
NCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIA
KEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLC
CFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWG
LNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYT
CLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIA
ILAASFGLLACIFFNKIYIILFKPSRNTIEDYKDDDDK

Ligands and cofactors

IDNameFormulaCopies
CLRCholesterolC27 H46 O8
9IG3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amineC18 H22 Cl N O2
CACalcium ionCa8
PO4Phosphate ionO4 P2
TCRCyclomethyltryptophanC12 H12 N2 O22
NAG2-acetamido-2-deoxy-beta-D-glucopyranoseC8 H15 N O66

Primary citation

Symmetric activation and modulation of the human calcium-sensing receptor. Park, J., Zuo, H., Frangaj, A. et al. Proc Natl Acad Sci U S A (2021) 118. DOI 10.1073/pnas.2115849118 · PubMed

Other PDB entries of the same protein (UniProt P41180 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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