7UNC: DNA-directed RNA polymerase subunit

Name: PDB 7UNC: Pol II-DSIF-SPT6-PAF1c-TFIIS complex with rewrapped nucleosome
Published: 2022-10-19
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: transcription

Pol II-DSIF-SPT6-PAF1c-TFIIS complex with rewrapped nucleosome. Determined by electron microscopy at 3.0 Å resolution. Released 19 Oct 2022.

Method: Electron microscopy
Resolution: 3.0 Å
Organisms: Sus scrofa, Homo sapiens, synthetic construct
Chains: 32
Atoms: 57,630
Mol. weight: 1577.92 kDa
Ligands: MG, ZN
Released: 19 Oct 2022

Explore 7UNC in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7UNC contains 382 α-helices and 389 β-strands across 29 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain a: 5 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	45-56	12
α-helix	64-78	15
β-strand	83-84	2	126
α-helix	86-110	25
α-helix	113-115	3
β-strand	119	1	127
α-helix	121-131	11

Chain A: 85 helices, 73 β-strands

Element	Residues	Length	Sheet
α-helix	14	1
β-strand	15	1	1
β-strand	20-22	3	2
α-helix	25-27	3
α-helix	28-34	7
β-strand	43	1	3
β-strand	47-49	3	4
β-strand	51-52	2	4
β-strand	56	1	3
β-strand	70	1	5
β-strand	77	1	5
α-helix	82-85	4
β-strand	86-94	9	6
α-helix	100-109	10
β-strand	110	1	7
β-strand	117	1	7
α-helix	124-132	9
α-helix	137-147	11
β-strand	190-194	5	8
β-strand	197-201	5	8
β-strand	214-216	3	8
α-helix	217	1
α-helix	218-226	9
α-helix	230-235	6
α-helix	245-247	3
β-strand	250-255	6	6
α-helix	258-260	3
α-helix	262-263	2
β-strand	264	1	9
α-helix	265	1
β-strand	272	1	9
α-helix	273-274	2
α-helix	275-292	18
α-helix	293-297	5
α-helix	300-318	19
α-helix	326-328	3
β-strand	329	1	10
α-helix	334	1
β-strand	335	1	10
α-helix	336	1
α-helix	339-343	5
α-helix	350-355	6
β-strand	357-358	2	11
β-strand	362-369	8	12
β-strand	377-381	5	12
α-helix	382-387	6
β-strand	389-393	5	13
α-helix	401-408	8
β-strand	416-420	5	13
β-strand	426	1	13
α-helix	429-431	3
β-strand	445-449	5	13
α-helix	450	1
β-strand	455-459	5	12
α-helix	466-468	3
β-strand	469-477	9	12
β-strand	482-484	3	12
α-helix	486-488	3
α-helix	489-492	4
β-strand	500-504	5	12
α-helix	509-518	10
β-strand	520	1	12
α-helix	521-524	4
β-strand	526-527	2	14
β-strand	532-533	2	14
α-helix	539-548	10
β-strand	554-556	3	15
α-helix	557-563	7
α-helix	564-566	3
α-helix	573-574	2
β-strand	575	1	16
α-helix	576-577	2
β-strand	579	1	15
β-strand	585-587	3	15
α-helix	588-595	8
β-strand	602-604	3	17
α-helix	611-613	3
β-strand	628-630	3	17
β-strand	635-637	3	17
α-helix	642-645	4
α-helix	652-659	8
α-helix	663-683	21
β-strand	686	1	18
α-helix	689-691	3
α-helix	696-721	26
α-helix	726-728	3
α-helix	733-759	27
α-helix	765-771	7
α-helix	778-781	4
α-helix	782-786	5
β-strand	789-790	2	19
β-strand	793	1	20
β-strand	796	1	20
α-helix	798-799	2
β-strand	802	1	21
β-strand	805	1	21
α-helix	811	1
α-helix	818-820	3
β-strand	822-823	2	19
α-helix	833-868	36
β-strand	872-873	2	22
β-strand	879-880	2	22
β-strand	886-888	3	22
α-helix	891-893	3
β-strand	896	1	23
β-strand	902-905	4	24
α-helix	917-920	4
α-helix	927-933	7
β-strand	934	1	25
α-helix	936-944	9
α-helix	946-969	24
β-strand	976-979	4	24
α-helix	983-993	11
α-helix	1001	1
β-strand	1002	1	25
α-helix	1006-1019	14
α-helix	1028-1037	10
α-helix	1039-1048	10
α-helix	1051-1052	2
α-helix	1053-1058	6
α-helix	1062-1079	18
β-strand	1080	1	23
α-helix	1081-1082	2
α-helix	1087-1101	15
α-helix	1121-1128	8
β-strand	1140-1142	3	26
β-strand	1143	1	27
α-helix	1146-1148	3
α-helix	1151-1161	11
β-strand	1164-1165	2	28
α-helix	1166-1169	4
β-strand	1170-1176	7	29
α-helix	1190-1194	5
β-strand	1211-1216	6	29
α-helix	1218-1221	4
α-helix	1228-1239	12
β-strand	1243-1247	5	29
β-strand	1255-1261	7	29
α-helix	1282-1295	14
β-strand	1297-1299	3	28
β-strand	1307-1310	4	26
β-strand	1319-1320	2	30
β-strand	1330-1331	2	30
β-strand	1335-1338	4	26
α-helix	1343-1348	6
β-strand	1352	1	27
β-strand	1358	1	26
α-helix	1362-1388	27
α-helix	1395-1406	12
α-helix	1416-1420	5
α-helix	1426-1429	4
α-helix	1435-1445	11
β-strand	1448-1449	2	2
α-helix	1454-1459	6
β-strand	1467	1	31
β-strand	1471-1475	5	32
α-helix	1479-1481	3
α-helix	1534-1537	4

Chain b: 4 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	25-28	4
α-helix	31-40	10
β-strand	46	1	127
α-helix	50-76	27
β-strand	80-81	2	126
α-helix	83-92	10
β-strand	97-98	2	128

Chain B: 60 helices, 81 β-strands

Element	Residues	Length	Sheet
α-helix	22-26	5
α-helix	31-36	6
α-helix	41-49	9
α-helix	50-54	5
α-helix	55-61	7
α-helix	63-64	2
β-strand	65-66	2	36
β-strand	83-93	11	36
α-helix	107-109	3
α-helix	110-115	6
β-strand	121-133	13	36
β-strand	140	1	36
β-strand	143-153	11	36
α-helix	154	1
β-strand	155	1	37
α-helix	168-173	6
β-strand	185-187	3	37
β-strand	190-194	5	37
α-helix	195	1
β-strand	196-200	5	38
α-helix	201	1
β-strand	206-208	3	39
β-strand	215-223	9	39
α-helix	231-232	2
β-strand	233-240	8	39
β-strand	256	1	39
β-strand	257	1	40
β-strand	263	1	41
β-strand	268	1	40
α-helix	269-275	7
α-helix	295-305	11
α-helix	314-323	10
β-strand	325	1	41
α-helix	332-341	10
α-helix	342-346	5
α-helix	349-351	3
α-helix	354-356	3
α-helix	360-377	18
α-helix	381-384	4
α-helix	388-390	3
β-strand	391-394	4	38
α-helix	398-407	10
α-helix	410-423	14
α-helix	431-434	4
α-helix	438-450	13
β-strand	453	1	42
α-helix	456-461	6
β-strand	463	1	42
β-strand	467-469	3	37
α-helix	475-482	8
β-strand	484-486	3	38
α-helix	490	1
α-helix	503-505	3
β-strand	509	1	43
β-strand	520	1	38
β-strand	523-525	3	38
β-strand	526	1	43
β-strand	531-532	2	44
α-helix	539-545	7
β-strand	551-552	2	45
α-helix	553-555	3
α-helix	558-561	4
β-strand	565-569	5	45
β-strand	572-577	6	45
α-helix	580-591	12
β-strand	602-606	5	45
β-strand	611-615	5	45
β-strand	621-627	7	44
β-strand	628-629	2	46
β-strand	632-633	2	46
α-helix	637-644	8
α-helix	653-657	5
β-strand	662-666	5	44
β-strand	675-676	2	44
α-helix	679-682	4
β-strand	695-696	2	44
α-helix	700-703	4
α-helix	708-710	3
α-helix	714-716	3
α-helix	719-728	10
β-strand	732	1	47
β-strand	734	1	48
β-strand	747-751	5	48
β-strand	755	1	49
β-strand	759-760	2	50
α-helix	763-766	4
β-strand	776-782	7	51
β-strand	783	1	18
β-strand	793-797	5	51
α-helix	798-802	5
β-strand	808-817	10	48
β-strand	827-829	3	52
β-strand	837	1	52
α-helix	845-847	3
β-strand	849	1	53
β-strand	853	1	53
α-helix	854-855	2
β-strand	859-860	2	48
β-strand	865-867	3	53
β-strand	869-872	4	52
β-strand	889-891	3	52
β-strand	894-895	2	53
α-helix	896-897	2
β-strand	902-911	10	48
β-strand	917-927	11	48
β-strand	934-937	4	51
β-strand	942-949	8	51
β-strand	956	1	54
β-strand	965-967	3	51
α-helix	969-971	3
α-helix	978-993	16
α-helix	996	1
β-strand	997-998	2	50
α-helix	1008-1017	10
β-strand	1025-1026	2	51
β-strand	1029	1	54
α-helix	1035	1
β-strand	1036	1	54
α-helix	1037	1
α-helix	1040	1
β-strand	1041-1050	10	51
β-strand	1051	1	47
α-helix	1055-1057	3
β-strand	1060-1062	3	12
β-strand	1067	1	55
β-strand	1074	1	55
β-strand	1085-1086	2	11
α-helix	1088-1097	10
β-strand	1099	1	31
α-helix	1100-1104	5
α-helix	1105-1109	5
β-strand	1115-1119	5	1
β-strand	1125	1	1
α-helix	1126	1
β-strand	1127-1129	3	56
β-strand	1134-1136	3	56
β-strand	1137	1	57
β-strand	1142	1	57
β-strand	1146-1150	5	1
α-helix	1153-1163	11
β-strand	1170-1172	3	2

Chain c: 5 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	17-21	5
α-helix	27-36	10
β-strand	42-43	2	33
α-helix	46-72	27
β-strand	77-78	2	34
α-helix	80-89	10
α-helix	91-96	6
β-strand	100-102	3	35

Chain C: 12 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	8-14	7	58
β-strand	18-24	7	58
α-helix	28-40	13
β-strand	43-55	13	59
α-helix	61-70	10
β-strand	73	1	60
α-helix	78-80	3
α-helix	83-84	2
α-helix	85-87	3
β-strand	99-106	8	59
β-strand	113-116	4	61
α-helix	117-119	3
β-strand	121-122	2	59
β-strand	129	1	60
α-helix	130-132	3
α-helix	147-148	2
β-strand	149-153	5	61
β-strand	158-169	12	59
α-helix	174-176	3
β-strand	179-186	8	58
α-helix	204-206	3
α-helix	218-220	3
β-strand	228-235	8	58
α-helix	241-268	28

Chain d: 4 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	35-45	11
β-strand	50-51	2	34
α-helix	53-80	28
β-strand	85-86	2	33
α-helix	88-98	11
α-helix	101-119	19

Chain D: 10 helices, 3 β-strands

Element	Residues	Length	Sheet
β-strand	16	1	64
α-helix	17-19	3
β-strand	21	1	64
α-helix	24-27	4
β-strand	30-31	2	32
α-helix	34-49	16
α-helix	55-58	4
α-helix	59-70	12
α-helix	77-88	12
α-helix	94-102	9
α-helix	108-114	7
α-helix	116-118	3
α-helix	124-137	14

21 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase subunit	A	protein	1984	Sus scrofa	A0A7M4DUC2
DNA-directed RNA polymerase subunit beta	B	protein	1251	Sus scrofa	A0A4X1TVZ5 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB3	C	protein	275	Sus scrofa	A0A481DF93 (AlphaFold model)
RPOL4c domain-containing protein	D	protein	184	Sus scrofa	A0A8D1GCS3 (AlphaFold model)
DNA-directed RNA polymerase II subunit E	E	protein	210	Sus scrofa	A0A4X1VTX4
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	127	Sus scrofa	A0A4X1VEK9
DNA-directed RNA polymerase II subunit RPB7	G	protein	172	Sus scrofa	A0A4X1VKG7
RPB8	H	protein	150	Sus scrofa
RPB9	I	protein	125	Sus scrofa
RPB10	J	protein	67	Sus scrofa
RPB11	K	protein	117	Sus scrofa
RNA polymerase II subunit K	L	protein	58	Sus scrofa	A0A4X1TRS6

16 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>7UNC_1 DNA-directed RNA polymerase subunit (chains A)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPT
SPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSY
SPSSPEYTPTSPKYSPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTS
PKYSPTSPTYSPTSPKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDS
DEEN

Sequence of entity 2 (B), FASTA

>7UNC_2 DNA-directed RNA polymerase subunit beta (chains B)
MCSTNLSQALAYFRAGANLTAASLWAGFRGSRRIFWERRKRKSLCLALRPGGACWRWLLA
VSCVSLRGLGAPGSCANMYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQ
LDSFDEFIQMSVQRIVEDAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDG
APSPMMPNEARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLL
NGLTDRDLCELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRS
CLENSSRPTSTIWVSMLARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRD
ILEHIIYDFEDPEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVL
QKEMLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFL
FRGMFKNLLKEVRIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQAR
AGVSQVLNRLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLV
KNLALMAYISVGSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQL
MNTLRKLRRQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQL
KEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMI
LGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRS
MEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGF
DQEEVFEKPTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELEGT
NRRYTKRDCSTFLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKG
TCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFN
DAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRA
RGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCG
IMAIANTRTHTYECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV

Sequence of entity 3 (C), FASTA

>7UNC_3 DNA-directed RNA polymerase II subunit RPB3 (chains C)
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLH
DEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDL
ISNSPRVIPVTSRNRDNDPSDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTA
GVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLR
PETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN

Sequence of entity 4 (D), FASTA

>7UNC_4 RPOL4c domain-containing protein (chains D)
MWGPAQPYSDSALSPKPRPFRAVFRGSALPFPAVRVEVRGRSMAAGGSDPRAGDVEEDAS
QLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEVFMKTLNYTARFSRFKNRE
TIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEGRFEDEELQQILDDIQTKR
SFQY

Sequence of entity 5 (E), FASTA

>7UNC_5 DNA-directed RNA polymerase II subunit E (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQFGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 6 (F), FASTA

>7UNC_6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIISD

Sequence of entity 7 (G), FASTA

>7UNC_7 DNA-directed RNA polymerase II subunit RPB7 (chains G)
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQ
PGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFD
PNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS

Sequence of entity 8 (H), FASTA

>7UNC_8 RPB8 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 9 (I), FASTA

>7UNC_9 RPB9 (chains I)
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
HRWTE

Sequence of entity 10 (J), FASTA

>7UNC_10 RPB10 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 11 (K), FASTA

>7UNC_11 RPB11 (chains K)
MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAG
YKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE

Sequence of entity 12 (L), FASTA

>7UNC_12 RNA polymerase II subunit K (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	1
ZN	Zinc ion	Zn	8

Primary citation

Structural basis of nucleosome retention during transcription elongation. Filipovski, M., Soffers, J.H.M., Vos, S.M. et al. Science (2022) 376:1313-1316. DOI 10.1126/science.abo3851 · PubMed

Other PDB entries of the same protein (UniProt A0A7M4DUC2), best resolution first:

9BZ0 1.9 Å, Structure of an STK19-containing TC-NER complex
8S52 2.9 Å, RNA polymerase II core initially transcribing complex with an ordered RNA of 10 nt
9EGX 2.9 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-hexasome, bp +27
9EGY 2.9 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-nucleosome, bp +27
9EGZ 2.9 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-nucleosome, bp +27
7UND 3.0 Å, Pol II-DSIF-SPT6-PAF1c-TFIIS-nucleosome complex (stalled at +38)
8A40 3.0 Å, Structure of mammalian Pol II-TFIIS elongation complex
6TED 3.1 Å, Structure of complete, activated transcription complex Pol II-DSIF-PAF-SPT6 uncovers…
9EH2 3.1 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-FACT nucleosome upstream
8A3Y 3.3 Å, Structure of mammalian Pol II-DSIF-SPT6-PAF1-TFIIS-hexasome elongation complex
9ER2 3.3 Å, PolII-TCR-STK19 structure.
8S54 3.4 Å, RNA polymerase II early elongation complex bound to TFIIE and TFIIF - state b (composite…

Browse structure collections

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